{"id":"https://openalex.org/W4413007415","doi":"https://doi.org/10.1142/s0129065725500613","title":"Integrative Multi-Adaptive Biological-Mental-Social Network Modeling of Changing Social and Organizational Contexts, Epigenetics, Personality Traits and Burnout Dimensions","display_name":"Integrative Multi-Adaptive Biological-Mental-Social Network Modeling of Changing Social and Organizational Contexts, Epigenetics, Personality Traits and Burnout Dimensions","publication_year":2025,"publication_date":"2025-08-06","ids":{"openalex":"https://openalex.org/W4413007415","doi":"https://doi.org/10.1142/s0129065725500613","pmid":"https://pubmed.ncbi.nlm.nih.gov/41122993"},"language":"en","primary_location":{"id":"doi:10.1142/s0129065725500613","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065725500613","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.vu.nl/en/publications/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021820320","display_name":"Debby Bouma","orcid":"https://orcid.org/0000-0001-6579-6626"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Debby Bouma","raw_affiliation_strings":["Social AI Group, Department of Computer Science, Vrije Universiteit Amsterdam, De Boelelaan 1111, 1081HV Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6579-6626","affiliations":[{"raw_affiliation_string":"Social AI Group, Department of Computer Science, Vrije Universiteit Amsterdam, De Boelelaan 1111, 1081HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083304312","display_name":"Jan Treur","orcid":"https://orcid.org/0000-0003-2466-9158"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Treur","raw_affiliation_strings":["Social AI Group, Department of Computer Science, Vrije Universiteit Amsterdam, De Boelelaan 1111, 1081HV Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2466-9158","affiliations":[{"raw_affiliation_string":"Social AI Group, Department of Computer Science, Vrije Universiteit Amsterdam, De Boelelaan 1111, 1081HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070835645","display_name":"Sophie C. F. Hendrikse","orcid":"https://orcid.org/0000-0002-2234-765X"},"institutions":[{"id":"https://openalex.org/I193700539","display_name":"Tilburg University","ror":"https://ror.org/04b8v1s79","country_code":"NL","type":"education","lineage":["https://openalex.org/I193700539"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sophie C. F. Hendrikse","raw_affiliation_strings":["Department of Methodology and Statistics, Tilburg University, Warandelaan 2, 5037AB Tilburg, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2234-765X","affiliations":[{"raw_affiliation_string":"Department of Methodology and Statistics, Tilburg University, Warandelaan 2, 5037AB Tilburg, The Netherlands","institution_ids":["https://openalex.org/I193700539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021820320"],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19364841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"12","first_page":"2550061","last_page":"2550061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11983","display_name":"Identity, Memory, and Therapy","score":0.9660000205039978,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burnout","display_name":"Burnout","score":0.6838637590408325},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.6254787445068359},{"id":"https://openalex.org/keywords/big-five-personality-traits","display_name":"Big Five personality traits","score":0.5625259876251221},{"id":"https://openalex.org/keywords/personality","display_name":"Personality","score":0.5547055602073669},{"id":"https://openalex.org/keywords/social-network","display_name":"Social network (sociolinguistics)","score":0.4368320107460022},{"id":"https://openalex.org/keywords/social-psychology","display_name":"Social psychology","score":0.39649346470832825},{"id":"https://openalex.org/keywords/social-media","display_name":"Social media","score":0.2063443958759308},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.19898387789726257},{"id":"https://openalex.org/keywords/clinical-psychology","display_name":"Clinical psychology","score":0.15923592448234558}],"concepts":[{"id":"https://openalex.org/C143916079","wikidata":"https://www.wikidata.org/wiki/Q2629248","display_name":"Burnout","level":2,"score":0.6838637590408325},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6254787445068359},{"id":"https://openalex.org/C2865642","wikidata":"https://www.wikidata.org/wiki/Q378132","display_name":"Big Five personality traits","level":3,"score":0.5625259876251221},{"id":"https://openalex.org/C187288502","wikidata":"https://www.wikidata.org/wiki/Q641118","display_name":"Personality","level":2,"score":0.5547055602073669},{"id":"https://openalex.org/C4727928","wikidata":"https://www.wikidata.org/wiki/Q17164759","display_name":"Social network (sociolinguistics)","level":3,"score":0.4368320107460022},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.39649346470832825},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.2063443958759308},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19898387789726257},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.15923592448234558},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002055","descriptor_name":"Burnout, Professional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002055","descriptor_name":"Burnout, Professional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002055","descriptor_name":"Burnout, Professional","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D002055","descriptor_name":"Burnout, Professional","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008960","descriptor_name":"Models, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008960","descriptor_name":"Models, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010551","descriptor_name":"Personality","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010551","descriptor_name":"Personality","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060756","descriptor_name":"Social Networking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060756","descriptor_name":"Social Networking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1142/s0129065725500613","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065725500613","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},{"id":"pmid:41122993","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41122993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of neural systems","raw_type":null},{"id":"pmh:oai:research.vu.nl:openaire/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bouma, D, Treur, J & Hendrikse, S C F 2025, 'Integrative Multi-Adaptive Biological-Mental-Social Network Modeling of Changing Social and Organizational Contexts, Epigenetics, Personality Traits and Burnout Dimensions', International journal of neural systems, vol. 35, no. 12, 2550061, pp. 1-31. https://doi.org/10.1142/S0129065725500613","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:tilburguniversity.edu:publications/a5e87059-a081-4bb0-bd17-d37e4fd0f6ca","is_oa":false,"landing_page_url":"https://research.tilburguniversity.edu/en/publications/a5e87059-a081-4bb0-bd17-d37e4fd0f6ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401490","display_name":"Research portal (Tilburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193700539","host_organization_name":"Tilburg University","host_organization_lineage":["https://openalex.org/I193700539"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bouma, D, Treur, J & Hendrikse, S C F 2025, 'Integrative multi-adaptive biological-mental-social network modelling of changing social and organizational contexts, epigenetics, personality traits and burnout dimensions', International Journal of Neural Systems. https://doi.org/10.1142/S0129065725500613","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","is_oa":true,"landing_page_url":"https://hdl.handle.net/1871.1/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bouma, D, Treur, J & Hendrikse, S C F 2025, 'Integrative Multi-Adaptive Biological-Mental-Social Network Modeling of Changing Social and Organizational Contexts, Epigenetics, Personality Traits and Burnout Dimensions', International journal of neural systems, vol. 35, no. 12, 2550061, pp. 1-31. https://doi.org/10.1142/S0129065725500613","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:research.vu.nl:openaire/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/dbe22f4c-3858-4981-9b66-ca61c4abc6ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bouma, D, Treur, J & Hendrikse, S C F 2025, 'Integrative Multi-Adaptive Biological-Mental-Social Network Modeling of Changing Social and Organizational Contexts, Epigenetics, Personality Traits and Burnout Dimensions', International journal of neural systems, vol. 35, no. 12, 2550061, pp. 1-31. https://doi.org/10.1142/S0129065725500613","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.550000011920929,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1928369584","https://openalex.org/W1971866798","https://openalex.org/W1983213171","https://openalex.org/W1983365283","https://openalex.org/W1987131356","https://openalex.org/W1993670422","https://openalex.org/W1998113992","https://openalex.org/W2009213548","https://openalex.org/W2010348352","https://openalex.org/W2022452929","https://openalex.org/W2045864095","https://openalex.org/W2058818389","https://openalex.org/W2067824254","https://openalex.org/W2073546855","https://openalex.org/W2087344719","https://openalex.org/W2089413793","https://openalex.org/W2096182145","https://openalex.org/W2096330673","https://openalex.org/W2114775249","https://openalex.org/W2116218460","https://openalex.org/W2138528278","https://openalex.org/W2140976637","https://openalex.org/W2145144342","https://openalex.org/W2145293159","https://openalex.org/W2145622598","https://openalex.org/W2145975061","https://openalex.org/W2147049995","https://openalex.org/W2159316671","https://openalex.org/W2163734099","https://openalex.org/W2334700346","https://openalex.org/W2550306825","https://openalex.org/W2618747300","https://openalex.org/W2899618128","https://openalex.org/W2901074246","https://openalex.org/W2901666904","https://openalex.org/W2903101093","https://openalex.org/W2970056595","https://openalex.org/W2971236623","https://openalex.org/W3021377274","https://openalex.org/W3022976993","https://openalex.org/W3089375619","https://openalex.org/W3092480446","https://openalex.org/W3092961660","https://openalex.org/W3106778890","https://openalex.org/W3142894110","https://openalex.org/W3184834694","https://openalex.org/W3195016804","https://openalex.org/W3196924035","https://openalex.org/W3200499517","https://openalex.org/W3208473129","https://openalex.org/W4210267418","https://openalex.org/W4210320048","https://openalex.org/W4210489023","https://openalex.org/W4220876460","https://openalex.org/W4225874545","https://openalex.org/W4286579687","https://openalex.org/W4289516832","https://openalex.org/W4313491489","https://openalex.org/W4313704054","https://openalex.org/W4313731288","https://openalex.org/W4321352100","https://openalex.org/W4366986945","https://openalex.org/W4367549692","https://openalex.org/W4367600844","https://openalex.org/W4380904914","https://openalex.org/W4389618426","https://openalex.org/W4392081055","https://openalex.org/W4392251971","https://openalex.org/W4399891536","https://openalex.org/W4402268494","https://openalex.org/W4403054186","https://openalex.org/W4404639001","https://openalex.org/W4405197610","https://openalex.org/W4408016272","https://openalex.org/W4409130765","https://openalex.org/W4409430822"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W2043487344","https://openalex.org/W2328607849","https://openalex.org/W2034909032","https://openalex.org/W2528063266","https://openalex.org/W2396691023","https://openalex.org/W2801770924","https://openalex.org/W3120573692","https://openalex.org/W4210275381"],"abstract_inverted_index":{"This":[0],"research":[1],"addresses":[2],"the":[3,13,19,74,95,117,120,138,164],"interplay":[4],"of":[5,24,123,159],"changing":[6,78],"social":[7],"and":[8,18,58,97],"organizational":[9,75],"context":[10,76],"factors":[11],"with":[12,108],"big":[14],"five":[15],"personality":[16,50],"traits":[17,51],"three":[20,121],"main":[21],"characterizing":[22],"elements":[23],"burnout.":[25],"A":[26],"computational":[27],"analysis":[28],"is":[29,77,89,105,128,143],"contributed":[30],"based":[31],"on":[32],"an":[33],"integrative":[34],"biological-mental-social":[35],"network":[36],"modeling":[37],"approach.":[38],"The":[39],"simulation":[40],"results":[41],"show":[42],"how":[43,91,146],"two":[44],"people":[45],"who":[46],"are":[47,63,113,169],"high":[48],"in":[49,70,79,100,106],"such":[52],"as":[53,153],"agreeableness,":[54],"openness,":[55],"extraversion,":[56],"conscientiousness,":[57],"highly":[59],"sensitive":[60],"to":[61,65],"neuroticism,":[62],"vulnerable":[64],"reaching":[66],"a":[67,80,85,101,134,154],"burnout":[68,124,135],"level":[69],"all":[71],"dimensions":[72,122],"whenever":[73],"less":[81],"favorable":[82],"direction.":[83],"By":[84],"What-If":[86],"analysis,":[87],"it":[88,127],"analyzed":[90],"important":[92],"characteristics":[93],"affect":[94,163],"outcomes":[96],"indicate":[98],"how,":[99],"qualitative":[102],"sense,":[103],"that":[104,126,130],"line":[107],"empirical":[109],"literature.":[110],"Several":[111],"differentiations":[112],"made.":[114],"In":[115],"particular,":[116],"connection":[118],"between":[119],"shows":[125],"possible":[129],"one":[131,160],"employee":[132,161],"reaches":[133],"state":[136],"while":[137],"other":[139],"does":[140,162],"not.":[141],"It":[142],"also":[144],"shown":[145],"therapy":[147,158],"alone":[148],"may":[149],"not":[150,170],"be":[151],"sufficient":[152],"long-term":[155],"treatment,":[156],"but":[157],"other.":[165],"As":[166],"numerical":[167,174],"data":[168],"(yet)":[171],"available,":[172],"further":[173],"validation":[175],"has":[176],"been":[177],"proposed":[178],"for":[179],"future":[180],"work.":[181]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-08-06T00:00:00"}