{"id":"https://openalex.org/W2899107284","doi":"https://doi.org/10.1142/s012906571850051x","title":"Identification of Hidden Sources by Estimating Instantaneous Causality in High-Dimensional Biomedical Time Series","display_name":"Identification of Hidden Sources by Estimating Instantaneous Causality in High-Dimensional Biomedical Time Series","publication_year":2018,"publication_date":"2018-10-29","ids":{"openalex":"https://openalex.org/W2899107284","doi":"https://doi.org/10.1142/s012906571850051x","mag":"2899107284","pmid":"https://pubmed.ncbi.nlm.nih.gov/30563386"},"language":"en","primary_location":{"id":"doi:10.1142/s012906571850051x","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s012906571850051x","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024874767","display_name":"Christos Koutlis","orcid":"https://orcid.org/0000-0003-3682-408X"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Koutlis","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083019131","display_name":"Vasilios \u039a. Kimiskidis","orcid":"https://orcid.org/0000-0002-3335-3019"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasilios K. Kimiskidis","raw_affiliation_strings":["Laboratory of Clinical Neurophysiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece"],"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Neurophysiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043840277","display_name":"Dimitris Kugiumtzis","orcid":"https://orcid.org/0000-0002-5337-5688"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Dimitris Kugiumtzis","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043840277"],"corresponding_institution_ids":["https://openalex.org/I21370196"],"apc_list":null,"apc_paid":null,"fwci":1.7816,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.84459018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"29","issue":"04","first_page":"1850051","last_page":"1850051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11270","display_name":"Complex Systems and Time Series Analysis","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/causality","display_name":"Causality (physics)","score":0.8074424266815186},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.5950382947921753},{"id":"https://openalex.org/keywords/lag","display_name":"Lag","score":0.5908603668212891},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.5578932762145996},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5559414625167847},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5355280637741089},{"id":"https://openalex.org/keywords/granger-causality","display_name":"Granger causality","score":0.5080709457397461},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.4885300397872925},{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.4877344071865082},{"id":"https://openalex.org/keywords/time-series","display_name":"Time series","score":0.46839284896850586},{"id":"https://openalex.org/keywords/series","display_name":"Series (stratigraphy)","score":0.4602109491825104},{"id":"https://openalex.org/keywords/independent-component-analysis","display_name":"Independent component analysis","score":0.4120435118675232},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3542439341545105},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3315492868423462},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3043028712272644},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.26329702138900757},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18550661206245422},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09168738126754761},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07886219024658203}],"concepts":[{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.8074424266815186},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5950382947921753},{"id":"https://openalex.org/C75778745","wikidata":"https://www.wikidata.org/wiki/Q342626","display_name":"Lag","level":2,"score":0.5908603668212891},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.5578932762145996},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5559414625167847},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5355280637741089},{"id":"https://openalex.org/C129824826","wikidata":"https://www.wikidata.org/wiki/Q2630107","display_name":"Granger causality","level":2,"score":0.5080709457397461},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.4885300397872925},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.4877344071865082},{"id":"https://openalex.org/C151406439","wikidata":"https://www.wikidata.org/wiki/Q186588","display_name":"Time series","level":2,"score":0.46839284896850586},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.4602109491825104},{"id":"https://openalex.org/C51432778","wikidata":"https://www.wikidata.org/wiki/Q1259145","display_name":"Independent component analysis","level":2,"score":0.4120435118675232},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3542439341545105},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3315492868423462},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3043028712272644},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.26329702138900757},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18550661206245422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09168738126754761},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07886219024658203},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1142/s012906571850051x","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s012906571850051x","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},{"id":"pmid:30563386","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30563386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of neural systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W206280282","https://openalex.org/W1527468221","https://openalex.org/W1925915230","https://openalex.org/W1959164575","https://openalex.org/W1972751079","https://openalex.org/W1976357731","https://openalex.org/W1979103407","https://openalex.org/W1979119950","https://openalex.org/W1987802692","https://openalex.org/W2011961540","https://openalex.org/W2040572095","https://openalex.org/W2040971434","https://openalex.org/W2045998748","https://openalex.org/W2049347439","https://openalex.org/W2052066602","https://openalex.org/W2061564920","https://openalex.org/W2069027902","https://openalex.org/W2070765152","https://openalex.org/W2077368122","https://openalex.org/W2077491345","https://openalex.org/W2085854554","https://openalex.org/W2101321538","https://openalex.org/W2103990426","https://openalex.org/W2109582949","https://openalex.org/W2110850615","https://openalex.org/W2129934604","https://openalex.org/W2132338668","https://openalex.org/W2147933447","https://openalex.org/W2156282037","https://openalex.org/W2159502107","https://openalex.org/W2272545495","https://openalex.org/W2296225605","https://openalex.org/W2317859329","https://openalex.org/W2400942168","https://openalex.org/W2534085000","https://openalex.org/W2551596472","https://openalex.org/W2556806676","https://openalex.org/W2586455683","https://openalex.org/W2738477618","https://openalex.org/W2774217687","https://openalex.org/W2947626232","https://openalex.org/W2963739582","https://openalex.org/W3102334527","https://openalex.org/W3105322001"],"related_works":["https://openalex.org/W4252230435","https://openalex.org/W2121429698","https://openalex.org/W2182042810","https://openalex.org/W55679925","https://openalex.org/W2035792466","https://openalex.org/W2977645287","https://openalex.org/W4251418261","https://openalex.org/W1972675643","https://openalex.org/W2154758532","https://openalex.org/W2133704721"],"abstract_inverted_index":{"The":[0,48,90,138],"study":[1],"of":[2,5,15,22,30,42,51,68,92,100,103,134,156,173,186],"connectivity":[3,33],"patterns":[4],"a":[6,19,98,114,132,153,166,187],"system's":[7],"variables,":[8,71],"such":[9],"as":[10,110,165],"multi-channel":[11],"electroencephalograms":[12],"(EEG),":[13],"is":[14,46,72,97,118,140],"utmost":[16],"importance":[17],"towards":[18],"better":[20],"understanding":[21],"its":[23],"internal":[24],"evolutionary":[25],"mechanisms.":[26],"Here,":[27],"the":[28,32,40,66,79,85,101,107,122,125,150,160,170,184],"problem":[29],"estimating":[31],"network":[34],"from":[35,55],"multivariate":[36],"time":[37],"series":[38],"in":[39,65,106,113,131],"presence":[41,67,102,185],"prominent":[43],"unobserved":[44,157],"variables":[45],"addressed.":[47],"causality":[49,94,174],"measure":[50],"partial":[52],"mutual":[53],"information":[54],"mixed":[56],"embedding":[57],"(PMIME),":[58],"designed":[59],"to":[60,74,142],"estimate":[61,75],"direct":[62],"lag-causal":[63],"effects":[64],"many":[69],"observed":[70,108],"adapted":[73],"also":[76],"zero-lag":[77],"effects,":[78],"so-called":[80],"instantaneous":[81,93,127],"causality.":[82],"We":[83],"term":[84],"proposed":[86],"advanced":[87],"method,":[88],"PMIME0.":[89],"estimation":[91],"by":[95,179,183],"PMIME0":[96,123],"signature":[99],"hidden":[104],"source":[105],"system,":[109],"demonstrated":[111,120],"analytically":[112],"toy":[115],"model.":[116],"It":[117],"further":[119],"that":[121],"identifies":[124],"true":[126],"with":[128,145],"great":[129],"accuracy":[130],"variety":[133],"high-dimensional":[135],"dynamical":[136],"systems.":[137],"method":[139],"applied":[141],"EEG":[143],"data":[144],"epileptiform":[146],"discharges":[147],"(EDs),":[148],"and":[149],"results":[151],"imply":[152],"strong":[154],"impact":[155],"confounders":[158],"during":[159,175],"EDs.":[161],"This":[162],"finding":[163],"comes":[164],"possible":[167],"explanation":[168],"for":[169],"increased":[171],"levels":[172],"epileptic":[176],"seizures":[177],"estimated":[178],"some":[180],"measures":[181],"affected":[182],"common":[188],"source.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}