{"id":"https://openalex.org/W2547104198","doi":"https://doi.org/10.1142/s0129065717500125","title":"Seizure Control in a Computational Model Using a Reinforcement Learning Stimulation Paradigm","display_name":"Seizure Control in a Computational Model Using a Reinforcement Learning Stimulation Paradigm","publication_year":2016,"publication_date":"2016-11-03","ids":{"openalex":"https://openalex.org/W2547104198","doi":"https://doi.org/10.1142/s0129065717500125","mag":"2547104198","pmid":"https://pubmed.ncbi.nlm.nih.gov/28030999"},"language":"en","primary_location":{"id":"doi:10.1142/s0129065717500125","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065717500125","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027381802","display_name":"Vivek Nagaraj","orcid":null},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Nagaraj","raw_affiliation_strings":["Graduate Program in Neuroscience, University of Minnesota \u2013 Twin Cities, 312 Church St SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Minnesota \u2013 Twin Cities, 312 Church St SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033424858","display_name":"Andrew Lamperski","orcid":"https://orcid.org/0000-0003-0383-1830"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Lamperski","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Minnesota \u2013 Twin Cities, 200 Union Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Minnesota \u2013 Twin Cities, 200 Union Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043792029","display_name":"Th\u00e9oden I. Netoff","orcid":"https://orcid.org/0000-0002-0115-1930"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theoden I Netoff","raw_affiliation_strings":["Department of Biomedical Engineering, University of Minnesota \u2013 Twin Cities, 312 Church St SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Minnesota \u2013 Twin Cities, 312 Church St SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043792029"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":1.8014,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.85148154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"27","issue":"07","first_page":"1750012","last_page":"1750012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"Reinforcement learning","score":0.8166473507881165},{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"Vagus nerve stimulation","score":0.6795015335083008},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.6195173263549805},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6067915558815002},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.570902407169342},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.5102663040161133},{"id":"https://openalex.org/keywords/brain-stimulation","display_name":"Brain stimulation","score":0.5031120181083679},{"id":"https://openalex.org/keywords/local-field-potential","display_name":"Local field potential","score":0.4395979344844818},{"id":"https://openalex.org/keywords/temporal-difference-learning","display_name":"Temporal difference learning","score":0.4301162660121918},{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.4272354543209076},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.3765299916267395},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3439541459083557},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2035159170627594},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16343927383422852},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.13596564531326294},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.09279155731201172},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"Vagus nerve","score":0.08981916308403015}],"concepts":[{"id":"https://openalex.org/C97541855","wikidata":"https://www.wikidata.org/wiki/Q830687","display_name":"Reinforcement learning","level":2,"score":0.8166473507881165},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.6795015335083008},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6195173263549805},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6067915558815002},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.570902407169342},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5102663040161133},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.5031120181083679},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.4395979344844818},{"id":"https://openalex.org/C196340769","wikidata":"https://www.wikidata.org/wiki/Q7698910","display_name":"Temporal difference learning","level":3,"score":0.4301162660121918},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.4272354543209076},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3765299916267395},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3439541459083557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2035159170627594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16343927383422852},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13596564531326294},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.09279155731201172},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.08981916308403015},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012054","descriptor_name":"Reinforcement, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012054","descriptor_name":"Reinforcement, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012054","descriptor_name":"Reinforcement, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0129065717500125","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065717500125","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},{"id":"pmid:28030999","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28030999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of neural systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306684","display_name":"Epilepsy Foundation","ror":"https://ror.org/01pxre019"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1494044142","https://openalex.org/W1976443859","https://openalex.org/W1987594947","https://openalex.org/W1991219514","https://openalex.org/W1997654862","https://openalex.org/W2003060166","https://openalex.org/W2004816127","https://openalex.org/W2037746973","https://openalex.org/W2038606869","https://openalex.org/W2052394872","https://openalex.org/W2073604663","https://openalex.org/W2081596682","https://openalex.org/W2098647834","https://openalex.org/W2109566484","https://openalex.org/W2124337098","https://openalex.org/W2135629133","https://openalex.org/W2154214065","https://openalex.org/W2160538589","https://openalex.org/W2167237768","https://openalex.org/W2410851752","https://openalex.org/W4214717370"],"related_works":["https://openalex.org/W4301397033","https://openalex.org/W2475049644","https://openalex.org/W2919512075","https://openalex.org/W2175322453","https://openalex.org/W2916389062","https://openalex.org/W4213216035","https://openalex.org/W4281649449","https://openalex.org/W2267907758","https://openalex.org/W4390665983","https://openalex.org/W4283814765"],"abstract_inverted_index":{"Neuromodulation":[0],"technologies":[1],"such":[2],"as":[3],"vagus":[4],"nerve":[5],"stimulation":[6,43,53,67,74,147,179,183],"and":[7,55,92,113,120,230],"deep":[8],"brain":[9],"stimulation,":[10,138],"have":[11],"shown":[12],"some":[13],"efficacy":[14,50],"in":[15,18,226],"controlling":[16,70],"seizures":[17,71,167,210],"medically":[19],"intractable":[20],"patients.":[21],"However,":[22],"inherent":[23],"patient-to-patient":[24],"variability":[25],"of":[26,34,127,193],"seizure":[27],"disorders":[28],"leads":[29],"to":[30,41,47,80,100,104,154,162,181,187,207],"a":[31,61,81,109,141],"wide":[32],"range":[33],"therapeutic":[35,49],"efficacy.":[36],"A":[37],"patient":[38],"specific":[39],"approach":[40],"determining":[42],"parameters":[44,164,189,205],"may":[45],"lead":[46],"increased":[48],"while":[51],"minimizing":[52],"energy":[54,184],"side":[56],"effects.":[57],"This":[58],"paper":[59],"presents":[60],"reinforcement":[62,102,131],"learning":[63,103,132],"algorithm":[64,133,159,176,196,219],"that":[65,143,165,173,198,203,217],"optimizes":[66],"frequency":[68,180],"for":[69,145],"with":[72,228],"minimum":[73],"energy.":[75],"We":[76,215],"apply":[77,101],"our":[78,170],"method":[79],"computational":[82],"model":[83,89],"called":[84],"the":[85,105,117,125,128,149,174,178,194,204,209,218,223],"epileptor.":[86],"The":[87,157],"epileptor":[88],"simulates":[90],"inter-ictal":[91],"ictal":[93],"local":[94],"field":[95],"potential":[96],"data.":[97],"In":[98],"order":[99],"Epileptor,":[106],"we":[107,123,139],"introduce":[108],"specialized":[110],"reward":[111,118],"function":[112,119],"state-space":[114],"discretization.":[115],"With":[116],"discretization":[121],"fixed,":[122],"test":[124],"effectiveness":[126],"temporal":[129],"difference":[130],"(TD(0)).":[134],"For":[135],"periodic":[136],"pulsatile":[137],"derive":[140],"relation":[142],"describes,":[144],"any":[146],"frequency,":[148],"minimal":[150],"pulse":[151],"amplitude":[152],"required":[153],"suppress":[155],"seizures.":[156],"TD(0)":[158,175,195],"is":[160,197,200],"able":[161],"identify":[163],"control":[166,208],"quickly.":[168],"Additionally,":[169],"results":[171],"show":[172,216],"refines":[177],"minimize":[182],"thereby":[185],"converging":[186],"optimal":[188,224],"reliably.":[190],"An":[191],"advantage":[192],"it":[199],"adaptive":[201],"so":[202],"necessary":[206],"can":[211,220],"change":[212],"over":[213],"time.":[214],"converge":[221],"on":[222],"solution":[225],"simulation":[227],"slow":[229],"fast":[231],"inter-seizure":[232],"intervals.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
