{"id":"https://openalex.org/W2534085000","doi":"https://doi.org/10.1142/s0129065717500101","title":"The Role of Thalamus Versus Cortex in Epilepsy: Evidence from Human Ictal Centromedian Recordings in Patients Assessed for Deep Brain Stimulation","display_name":"The Role of Thalamus Versus Cortex in Epilepsy: Evidence from Human Ictal Centromedian Recordings in Patients Assessed for Deep Brain Stimulation","publication_year":2016,"publication_date":"2016-10-25","ids":{"openalex":"https://openalex.org/W2534085000","doi":"https://doi.org/10.1142/s0129065717500101","mag":"2534085000","pmid":"https://pubmed.ncbi.nlm.nih.gov/28030998"},"language":"en","primary_location":{"id":"doi:10.1142/s0129065717500101","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065717500101","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000563264","display_name":"David Mart\u00edn-L\u00f3pez","orcid":"https://orcid.org/0000-0002-0067-5855"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]},{"id":"https://openalex.org/I4210143345","display_name":"Kingston Hospital","ror":"https://ror.org/04ar23e02","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801636071","https://openalex.org/I4210143345"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"David Mart\u00edn-L\u00f3pez","raw_affiliation_strings":["Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain","Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","Department of Clinical Neurophysiology, Kingston Hospital NHS FT, London, UK","Department of Clinical Neurophysiology, St George\u2019s University Hospitals NHS FT, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, Kingston Hospital NHS FT, London, UK","institution_ids":["https://openalex.org/I4210143345"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, St George\u2019s University Hospitals NHS FT, London, UK","institution_ids":["https://openalex.org/I2801196673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058201554","display_name":"Diego Jim\u00e9nez\u2010Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-0147-107X"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]},{"id":"https://openalex.org/I69094615","display_name":"Universidad San Francisco de Quito","ror":"https://ror.org/01r2c3v86","country_code":"EC","type":"education","lineage":["https://openalex.org/I69094615"]}],"countries":["EC","GB"],"is_corresponding":false,"raw_author_name":"Diego Jim\u00e9nez-Jim\u00e9nez","raw_affiliation_strings":["Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK","Universidad San Francisco de Quito, School of Medicine, Quito, Ecuador"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK","institution_ids":["https://openalex.org/I4210153400"]},{"raw_affiliation_string":"Universidad San Francisco de Quito, School of Medicine, Quito, Ecuador","institution_ids":["https://openalex.org/I69094615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017483105","display_name":"Lidia Caba\u00f1\u00e9s-Mart\u00ednez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089583","display_name":"Cl\u00ednica Rementer\u00eda","ror":"https://ror.org/00b3d7291","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210089583"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lidia Caba\u00f1\u00e9s-Mart\u00ednez","raw_affiliation_strings":["Servicio de Neurofisiolog\u00eda Cl\u00ednica Hospital Ram\u00f3n y Cajal, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Neurofisiolog\u00eda Cl\u00ednica Hospital Ram\u00f3n y Cajal, Madrid, Spain","institution_ids":["https://openalex.org/I4210089583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089143079","display_name":"Richard Selway","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard P. Selway","raw_affiliation_strings":["Department of Neurosurgery, King\u2019s College Hospital NHS FT, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, King\u2019s College Hospital NHS FT, London, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013584826","display_name":"Antonio Valent\u0131\u0301n","orcid":"https://orcid.org/0000-0003-0449-5234"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Antonio Valent\u00edn","raw_affiliation_strings":["Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain","Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073858586","display_name":"Gonzalo Alarc\u00f3n","orcid":"https://orcid.org/0009-0003-6638-9194"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]},{"id":"https://openalex.org/I49828101","display_name":"Hamad Medical Corporation","ror":"https://ror.org/02zwb6n98","country_code":"QA","type":"nonprofit","lineage":["https://openalex.org/I49828101"]}],"countries":["ES","GB","QA"],"is_corresponding":false,"raw_author_name":"Gonzalo Alarc\u00f3n","raw_affiliation_strings":["Comprehensive Epilepsy Center Neuroscience Institute, Academic Health Systems, Hamad Medical Corporation, Doha, Qatar","Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain","Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Epilepsy Center Neuroscience Institute, Academic Health Systems, Hamad Medical Corporation, Doha, Qatar","institution_ids":["https://openalex.org/I49828101"]},{"raw_affiliation_string":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Department of Basic and Clinical Neuroscience, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Clinical Neurophysiology, King\u2019s College Hospital NHS FT, London, UK","institution_ids":["https://openalex.org/I4210153400"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6757,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.73976592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"27","issue":"07","first_page":"1750010","last_page":"1750010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.5827000141143799,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.5827000141143799,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.2685000002384186,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.8919121026992798},{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.8306448459625244},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.7175031304359436},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6582398414611816},{"id":"https://openalex.org/keywords/cortex","display_name":"Cortex (anatomy)","score":0.6375047564506531},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.582169771194458},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5000042915344238},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42017877101898193},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.41805270314216614},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13127049803733826},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.050176918506622314}],"concepts":[{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.8919121026992798},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.8306448459625244},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7175031304359436},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6582398414611816},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.6375047564506531},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.582169771194458},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5000042915344238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42017877101898193},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.41805270314216614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13127049803733826},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.050176918506622314},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004829","descriptor_name":"Epilepsy, Generalized","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013686","descriptor_name":"Telemetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013686","descriptor_name":"Telemetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013686","descriptor_name":"Telemetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014741","descriptor_name":"Video Recording","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014741","descriptor_name":"Video Recording","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014741","descriptor_name":"Video Recording","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017034","descriptor_name":"Epilepsy, Frontal Lobe","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058256","descriptor_name":"Brain Waves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058256","descriptor_name":"Brain Waves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058256","descriptor_name":"Brain Waves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0129065717500101","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065717500101","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},{"id":"pmid:28030998","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28030998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of neural systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1483356713","https://openalex.org/W1537864580","https://openalex.org/W1809188141","https://openalex.org/W1886118302","https://openalex.org/W1964664472","https://openalex.org/W1967155947","https://openalex.org/W1968321483","https://openalex.org/W1968571209","https://openalex.org/W1979618667","https://openalex.org/W1980276616","https://openalex.org/W1984250080","https://openalex.org/W1984976062","https://openalex.org/W1987678928","https://openalex.org/W1990688163","https://openalex.org/W2000645076","https://openalex.org/W2006518915","https://openalex.org/W2006815061","https://openalex.org/W2011106061","https://openalex.org/W2016910084","https://openalex.org/W2021661569","https://openalex.org/W2022890204","https://openalex.org/W2025705850","https://openalex.org/W2033612743","https://openalex.org/W2037668742","https://openalex.org/W2038432039","https://openalex.org/W2040016151","https://openalex.org/W2041847367","https://openalex.org/W2045508612","https://openalex.org/W2048808896","https://openalex.org/W2049871805","https://openalex.org/W2052990681","https://openalex.org/W2056067392","https://openalex.org/W2057248812","https://openalex.org/W2063332447","https://openalex.org/W2075573027","https://openalex.org/W2080903095","https://openalex.org/W2081020218","https://openalex.org/W2089995951","https://openalex.org/W2095266848","https://openalex.org/W2100371953","https://openalex.org/W2102030794","https://openalex.org/W2109108729","https://openalex.org/W2109930285","https://openalex.org/W2111931691","https://openalex.org/W2120235559","https://openalex.org/W2124613059","https://openalex.org/W2135962619","https://openalex.org/W2142679555","https://openalex.org/W2144060956","https://openalex.org/W2148799153","https://openalex.org/W2152688053","https://openalex.org/W2155306637","https://openalex.org/W2158468574","https://openalex.org/W2159432306","https://openalex.org/W2159502107","https://openalex.org/W2160184536","https://openalex.org/W2162951269","https://openalex.org/W2168000543","https://openalex.org/W2415874715","https://openalex.org/W2579973636","https://openalex.org/W2602148597","https://openalex.org/W2621989522","https://openalex.org/W3114851684"],"related_works":["https://openalex.org/W2008631356","https://openalex.org/W2087401364","https://openalex.org/W3104061430","https://openalex.org/W2016645643","https://openalex.org/W1990627463","https://openalex.org/W2168763307","https://openalex.org/W4281614007","https://openalex.org/W2152120467","https://openalex.org/W4385879350","https://openalex.org/W2135525056"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,13,31,259],"onset":[2,108,115,149,170],"of":[3,16,33,116,127,236,241,249,269],"generalized":[4,86,185],"seizures":[5,53,212],"is":[6,36,47,239],"a":[7],"long":[8],"debated":[9],"subject":[10],"in":[11,20,49,54,125,130,155,195,209,218],"epilepsy.":[12,94],"relative":[14],"roles":[15],"cortex":[17,41,157],"and":[18,22,51,65,82,112,132],"thalamus":[19,131,188,214,238,260],"initiating":[21,50],"maintaining":[23,52,266],"the":[24,34,40,43,113,145,156,164,187,196,205,213,219,229,233,237,247,267],"different":[25],"seizure":[26,107,169,197,220],"types":[27],"are":[28],"unclear.":[29],"OBJECTIVE:":[30],"purpose":[32],"study":[35],"to":[37,144,174,256],"estimate":[38],"whether":[39],"or":[42,193],"centromedian":[44,234],"thalamic":[45,64,118,180,257],"nucleus":[46,235],"leading":[48,117],"humans.":[55],"METHODS:":[56],"We":[57],"report":[58],"human":[59,184,210],"ictal":[60,148,270],"recordings":[61],"with":[62,99,122,152,177],"simultaneous":[63],"cortical":[66,111],"electrodes":[67],"from":[68],"three":[69],"patients":[70],"without":[71],"anesthesia":[72],"being":[73],"assessed":[74],"for":[75,265],"deep":[76],"brain":[77],"stimulation":[78],"(DBS).":[79],"Patients":[80],"1":[81],"2":[83],"had":[84,91],"idiopathic":[85],"epilepsy":[87],"whereas":[88],"patient":[89,105,135,167],"3":[90],"frontal":[92,175,211],"lobe":[93],"Visual":[95],"inspection":[96],"was":[97,109,120,150,171],"combined":[98],"nonlinear":[100],"correlation":[101],"analysis.":[102],"RESULTS:":[103],"In":[104,134,166,183,207,231],"1,":[106],"bilateral":[110,139],"belated":[114,178],"discharges":[119,142,153,254],"associated":[121],"an":[123],"increase":[124],"rhythmicity":[126,268],"discharges,":[128],"both":[129],"cortex.":[133,206,230],"2,":[136],"we":[137],"observed":[138],"independent":[140,250],"interictal":[141],"restricted":[143,173,255],"thalamus.":[146,165],"However,":[147],"diffuse,":[151],"larger":[154],"even":[158],"though":[159],"they":[160],"were":[161],"led":[162],"by":[163,246],"3,":[168],"largely":[172],"structures,":[176],"lagging":[179],"involvement.":[181],"CONCLUSION:":[182],"seizures,":[186],"may":[189,261],"become":[190],"involved":[191,216],"early":[192],"late":[194,217],"but,":[198],"once":[199,222],"it":[200,203,223,226],"becomes":[201,224],"involved,":[202,225],"leads":[204],"contrast,":[208],"gets":[215],"and,":[221],"lags":[227],"behind":[228],"addition,":[232],"capable":[240],"autonomous":[242],"epileptogenesis":[243],"as":[244],"suggested":[245],"presence":[248],"focal":[251],"unilateral":[252],"epileptiform":[253],"structures.":[258],"also":[262],"be":[263],"responsible":[264],"discharges.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}