{"id":"https://openalex.org/W2517697301","doi":"https://doi.org/10.1142/s0129065717500046","title":"Changes of Ionic Concentrations During Seizure Transitions \u2014 A Modeling Study","display_name":"Changes of Ionic Concentrations During Seizure Transitions \u2014 A Modeling Study","publication_year":2016,"publication_date":"2016-09-09","ids":{"openalex":"https://openalex.org/W2517697301","doi":"https://doi.org/10.1142/s0129065717500046","mag":"2517697301","pmid":"https://pubmed.ncbi.nlm.nih.gov/27802792"},"language":"en","primary_location":{"id":"doi:10.1142/s0129065717500046","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065717500046","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054451970","display_name":"Damiano Gentiletti","orcid":null},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Damiano Gentiletti","raw_affiliation_strings":["Department of Biomedical Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003253565","display_name":"Piotr Suffczy\u0144ski","orcid":"https://orcid.org/0000-0002-2300-1415"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Piotr Suffczynski","raw_affiliation_strings":["Department of Biomedical Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017476278","display_name":"Vadym Gnatkovsky","orcid":"https://orcid.org/0000-0002-4543-0464"},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vadym Gnatkovsky","raw_affiliation_strings":["Unit of Epileptology and Experimental Neurophysiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Unit of Epileptology and Experimental Neurophysiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027294480","display_name":"Marco de Curtis","orcid":"https://orcid.org/0000-0001-7443-6737"},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco de Curtis","raw_affiliation_strings":["Unit of Epileptology and Experimental Neurophysiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Unit of Epileptology and Experimental Neurophysiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003253565"],"corresponding_institution_ids":["https://openalex.org/I4654613"],"apc_list":null,"apc_paid":null,"fwci":1.3001,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.79467846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"27","issue":"04","first_page":"1750004","last_page":"1750004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.7153596878051758},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6317609548568726},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.6058133840560913},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.5612145662307739},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.5577486157417297},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"Neurotransmission","score":0.5253802537918091},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.46550896763801575},{"id":"https://openalex.org/keywords/synchronization","display_name":"Synchronization (alternating current)","score":0.43777021765708923},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.43603354692459106},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.40649932622909546},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38976290822029114},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3563648462295532},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2509762644767761},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1186738908290863},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.09800386428833008}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7153596878051758},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6317609548568726},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6058133840560913},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5612145662307739},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5577486157417297},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5253802537918091},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.46550896763801575},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.43777021765708923},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43603354692459106},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.40649932622909546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38976290822029114},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3563648462295532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2509762644767761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1186738908290863},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09800386428833008},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000096922","descriptor_name":"K Cl- Cotransporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096922","descriptor_name":"K Cl- Cotransporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096922","descriptor_name":"K Cl- Cotransporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096922","descriptor_name":"K Cl- Cotransporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0129065717500046","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065717500046","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},{"id":"pmid:27802792","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27802792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of neural systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W55360413","https://openalex.org/W1134182094","https://openalex.org/W1533616161","https://openalex.org/W1598480035","https://openalex.org/W1836848727","https://openalex.org/W1963710870","https://openalex.org/W1968687601","https://openalex.org/W1970536698","https://openalex.org/W1971931358","https://openalex.org/W1973400846","https://openalex.org/W1973995482","https://openalex.org/W1975893829","https://openalex.org/W1985454023","https://openalex.org/W1994319185","https://openalex.org/W2016385700","https://openalex.org/W2017783331","https://openalex.org/W2017791457","https://openalex.org/W2019137683","https://openalex.org/W2019203278","https://openalex.org/W2049268334","https://openalex.org/W2065811708","https://openalex.org/W2067292769","https://openalex.org/W2069963369","https://openalex.org/W2076462587","https://openalex.org/W2078156409","https://openalex.org/W2078261043","https://openalex.org/W2082241343","https://openalex.org/W2082969312","https://openalex.org/W2094131991","https://openalex.org/W2095984446","https://openalex.org/W2125731194","https://openalex.org/W2128519053","https://openalex.org/W2133100820","https://openalex.org/W2145912187","https://openalex.org/W2150497419","https://openalex.org/W2152472106","https://openalex.org/W2155965080","https://openalex.org/W2158645550","https://openalex.org/W2162011760","https://openalex.org/W2167970717","https://openalex.org/W2168690368","https://openalex.org/W2219448291","https://openalex.org/W2262841875","https://openalex.org/W2441717400","https://openalex.org/W4388117959"],"related_works":["https://openalex.org/W2130055373","https://openalex.org/W2046007129","https://openalex.org/W3031633328","https://openalex.org/W2089619207","https://openalex.org/W2129833097","https://openalex.org/W2021431294","https://openalex.org/W2027965057","https://openalex.org/W4362601934","https://openalex.org/W1979921253","https://openalex.org/W3102980008"],"abstract_inverted_index":{"Traditionally,":[0],"it":[1,19],"is":[2,9,109,151],"considered":[3],"that":[4,23,86,115],"neuronal":[5],"synchronization":[6],"in":[7,46,116,127,154,169],"epilepsy":[8],"caused":[10],"by":[11],"a":[12,51,155],"chain":[13],"reaction":[14],"of":[15,40,54,63,106,122,131,140,166],"synaptic":[16,31,41,158],"excitation.":[17],"However,":[18],"has":[20],"been":[21],"shown":[22],"synchronous":[24],"epileptiform":[25],"activity":[26],"may":[27,94,125],"also":[28],"arise":[29],"without":[30],"transmission.":[32],"In":[33,111],"order":[34],"to":[35,163,172],"investigate":[36],"the":[37,58,87,99,117,138,141,164,170],"respective":[38],"roles":[39],"interactions":[42],"and":[43,73,80,144],"nonsynaptic":[44,167],"mechanisms":[45,168],"seizure":[47],"transitions,":[48],"we":[49,113],"developed":[50],"computational":[52],"model":[53,119],"hippocampal":[55],"cells,":[56],"involving":[57],"extracellular":[59,81,132],"space,":[60],"realistic":[61],"dynamics":[62,108],"[Formula:":[64,67,70,74,133],"see":[65,68,71,75,134],"text],":[66,69,135],"text]":[72,76],"ions,":[77],"glial":[78],"uptake":[79],"diffusion":[82],"mechanisms.":[83],"We":[84],"show":[85,114],"network":[88],"behavior":[89,101],"with":[90],"fixed":[91],"ionic":[92,107],"concentrations":[93],"be":[95],"quite":[96],"different":[97],"from":[98],"neurons'":[100],"when":[102],"more":[103],"detailed":[104],"modeling":[105],"included.":[110],"particular,":[112],"extended":[118],"strong":[120],"discharge":[121],"inhibitory":[123],"interneurons":[124],"result":[126],"long":[128],"lasting":[129],"accumulation":[130],"which":[136],"sustains":[137],"depolarization":[139],"principal":[142],"cells":[143],"causes":[145],"their":[146],"pathological":[147],"discharges.":[148],"This":[149],"effect":[150],"not":[152],"present":[153],"reduced,":[156],"purely":[157],"network.":[159],"These":[160],"results":[161],"point":[162],"importance":[165],"transition":[171],"seizure.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}