{"id":"https://openalex.org/W1980027718","doi":"https://doi.org/10.1142/s0129065715500215","title":"Gap Junctions as Common Cause of High-Frequency Oscillations and Epileptic Seizures in a Computational Cascade of Neuronal Mass and Compartmental Modeling","display_name":"Gap Junctions as Common Cause of High-Frequency Oscillations and Epileptic Seizures in a Computational Cascade of Neuronal Mass and Compartmental Modeling","publication_year":2015,"publication_date":"2015-04-27","ids":{"openalex":"https://openalex.org/W1980027718","doi":"https://doi.org/10.1142/s0129065715500215","mag":"1980027718"},"language":"en","primary_location":{"id":"doi:10.1142/s0129065715500215","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065715500215","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027437528","display_name":"Robert M. Helling","orcid":"https://orcid.org/0000-0003-0277-8484"},"institutions":[{"id":"https://openalex.org/I4210161862","display_name":"Stichting Epilepsie Instellingen Nederland","ror":"https://ror.org/051ae7717","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210161862"]},{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Robert M. Helling","raw_affiliation_strings":["Faculty of Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands","Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Faculty of Technical Medicine, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands","institution_ids":["https://openalex.org/I4210161862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109121749","display_name":"Marc Koppert","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161862","display_name":"Stichting Epilepsie Instellingen Nederland","ror":"https://ror.org/051ae7717","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210161862"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marc M. J. Koppert","raw_affiliation_strings":["Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands","institution_ids":["https://openalex.org/I4210161862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048319252","display_name":"Gerhard H. Visser","orcid":"https://orcid.org/0000-0001-6708-6396"},"institutions":[{"id":"https://openalex.org/I4210161862","display_name":"Stichting Epilepsie Instellingen Nederland","ror":"https://ror.org/051ae7717","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210161862"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerhard H. Visser","raw_affiliation_strings":["Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands","institution_ids":["https://openalex.org/I4210161862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010673868","display_name":"Stiliyan Kalitzin","orcid":"https://orcid.org/0000-0002-7028-7778"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210161862","display_name":"Stichting Epilepsie Instellingen Nederland","ror":"https://ror.org/051ae7717","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210161862"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Stiliyan N. Kalitzin","raw_affiliation_strings":["Image Sciences Institute \u2013 University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands","Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Image Sciences Institute \u2013 University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW, Heemstede, The Netherlands","institution_ids":["https://openalex.org/I4210161862"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027437528"],"corresponding_institution_ids":["https://openalex.org/I4210161862","https://openalex.org/I94624287"],"apc_list":null,"apc_paid":null,"fwci":0.6452,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6747821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"06","first_page":"1550021","last_page":"1550021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.7752286195755005},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6000773310661316},{"id":"https://openalex.org/keywords/cascade","display_name":"Cascade","score":0.5984348058700562},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5434761643409729},{"id":"https://openalex.org/keywords/gap-junction","display_name":"Gap junction","score":0.5338097214698792},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4430360496044159},{"id":"https://openalex.org/keywords/epileptic-seizure","display_name":"Epileptic seizure","score":0.41975829005241394},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41936206817626953},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4158562421798706},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20527610182762146},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19645363092422485},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19574987888336182},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.14596039056777954}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.7752286195755005},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6000773310661316},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.5984348058700562},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5434761643409729},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.5338097214698792},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4430360496044159},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.41975829005241394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41936206817626953},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4158562421798706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20527610182762146},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19645363092422485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19574987888336182},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.14596039056777954},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s0129065715500215","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0129065715500215","pdf_url":null,"source":{"id":"https://openalex.org/S197665576","display_name":"International Journal of Neural Systems","issn_l":"0129-0657","issn":["0129-0657","1793-6462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Neural Systems","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1752287441","https://openalex.org/W1968028223","https://openalex.org/W1974021959","https://openalex.org/W1976889725","https://openalex.org/W1988878611","https://openalex.org/W1990627393","https://openalex.org/W1991733372","https://openalex.org/W1997629662","https://openalex.org/W2000467456","https://openalex.org/W2001694188","https://openalex.org/W2003996088","https://openalex.org/W2005950280","https://openalex.org/W2007352211","https://openalex.org/W2008518032","https://openalex.org/W2013427676","https://openalex.org/W2019066801","https://openalex.org/W2021287823","https://openalex.org/W2030670571","https://openalex.org/W2045582728","https://openalex.org/W2046432382","https://openalex.org/W2050996013","https://openalex.org/W2051819825","https://openalex.org/W2059080764","https://openalex.org/W2067367785","https://openalex.org/W2067699039","https://openalex.org/W2069305565","https://openalex.org/W2104930442","https://openalex.org/W2109660618","https://openalex.org/W2121680855","https://openalex.org/W2126179966","https://openalex.org/W2129577612","https://openalex.org/W2131519617","https://openalex.org/W2141901128","https://openalex.org/W2144440960","https://openalex.org/W2151189162","https://openalex.org/W2152730994","https://openalex.org/W2160607236","https://openalex.org/W2399067859","https://openalex.org/W4297154240"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W1964519618","https://openalex.org/W3118640947","https://openalex.org/W4388308731","https://openalex.org/W2042003698","https://openalex.org/W1969697984","https://openalex.org/W3048730783","https://openalex.org/W1992416820","https://openalex.org/W2363907062","https://openalex.org/W2393137063"],"abstract_inverted_index":{"High":[0],"frequency":[1],"oscillations":[2],"(HFO)":[3],"appear":[4],"to":[5,37,152,184],"be":[6],"a":[7,26,49,61,94,130],"promising":[8],"marker":[9],"for":[10],"delineating":[11],"the":[12,71,77,102,112,123,127,147,150,161,164],"seizure":[13,41],"onset":[14],"zone":[15],"(SOZ)":[16],"in":[17,179],"patients":[18],"with":[19,160],"localization":[20],"related":[21],"epilepsy.":[22],"It":[23],"remains,":[24],"however,":[25],"purely":[27],"observational":[28],"phenomenon":[29],"and":[30,40,60,76,97,120],"no":[31],"common":[32],"mechanism":[33],"has":[34],"been":[35],"proposed":[36],"relate":[38],"HFOs":[39,75,119],"generation.":[42],"In":[43],"this":[44,86],"work":[45],"we":[46,88],"show":[47,110],"that":[48,111,137,173],"cascade":[50],"of":[51,74,79,114,126,146,156,163,166],"two":[52],"computational":[53],"models,":[54],"one":[55,63],"on":[56,64,93,101],"detailed":[57],"compartmental":[58],"scale":[59,67],"second":[62],"neural":[65,105],"mass":[66,106],"can":[68,117,138],"explain":[69],"both":[70],"autonomous":[72],"generation":[73],"presence":[78],"epileptic":[80,141,144,154],"seizures":[81],"as":[82],"emergent":[83],"properties.":[84],"To":[85],"end":[87],"introduce":[89],"axonal\u2013axonal":[90,167],"gap":[91,115,168],"junctions":[92,116],"microscopic":[95],"level":[96,104],"explore":[98],"their":[99],"impact":[100],"higher":[103],"model":[107],"(NMM).":[108],"We":[109,170],"addition":[113],"generate":[118,140,153],"simultaneously":[121],"shift":[122],"operational":[124],"point":[125],"NMM":[128],"from":[129],"steady":[131],"state":[132],"network":[133],"into":[134],"bistable":[135],"behavior":[136],"autonomously":[139],"seizures.":[142],"The":[143],"properties":[145],"system,":[148],"or":[149],"probability":[151],"type":[155],"activity,":[157],"increases":[158],"gradually":[159],"increase":[162],"density":[165],"junctions.":[169],"further":[171],"demonstrate":[172],"ad":[174],"hoc":[175],"HFO":[176],"detectors":[177],"used":[178],"previous":[180],"studies":[181],"are":[182],"applicable":[183],"our":[185],"simulated":[186],"data.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}