{"id":"https://openalex.org/W4311559146","doi":"https://doi.org/10.1137/22m147668x","title":"A Continuous Integral Model for White Blood Cell Production","display_name":"A Continuous Integral Model for White Blood Cell Production","publication_year":2022,"publication_date":"2022-12-15","ids":{"openalex":"https://openalex.org/W4311559146","doi":"https://doi.org/10.1137/22m147668x"},"language":"en","primary_location":{"id":"doi:10.1137/22m147668x","is_oa":false,"landing_page_url":"https://doi.org/10.1137/22m147668x","pdf_url":null,"source":{"id":"https://openalex.org/S77200987","display_name":"SIAM Journal on Applied Mathematics","issn_l":"0036-1399","issn":["0036-1399","1095-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Journal on Applied Mathematics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101743869","display_name":"Yaming Zhang","orcid":"https://orcid.org/0000-0002-9479-079X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210158445","display_name":"Institute of Natural Science","ror":"https://ror.org/004tze884","country_code":"KP","type":"education","lineage":["https://openalex.org/I4210158445"]}],"countries":["CN","KP"],"is_corresponding":false,"raw_author_name":"Yaming Zhang","raw_affiliation_strings":["School of Mathematics and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, People\u2019s Republic of China","School of Mathematics and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210158445"]},{"raw_affiliation_string":"School of Mathematics and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210158445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040978612","display_name":"Thomas Stiehl","orcid":"https://orcid.org/0000-0001-9686-9197"},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Stiehl","raw_affiliation_strings":["Institute for Computational Biomedicine - Disease Modeling, RWTH Aachen Medical School, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Biomedicine - Disease Modeling, RWTH Aachen Medical School, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971791","display_name":"Min Tang","orcid":"https://orcid.org/0000-0002-1275-6185"},"institutions":[{"id":"https://openalex.org/I4210158445","display_name":"Institute of Natural Science","ror":"https://ror.org/004tze884","country_code":"KP","type":"education","lineage":["https://openalex.org/I4210158445"]}],"countries":["KP"],"is_corresponding":false,"raw_author_name":"Min Tang","raw_affiliation_strings":["School of Mathematics and Institute of Natural Sciences, MOE-LSC, and Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, People\u2019s Republic of China","School of Mathematics and Institute of Natural Sciences, MOE-LSC, and Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-1275-6185","affiliations":[{"raw_affiliation_string":"School of Mathematics and Institute of Natural Sciences, MOE-LSC, and Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210158445"]},{"raw_affiliation_string":"School of Mathematics and Institute of Natural Sciences, MOE-LSC, and Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210158445"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5915,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6990579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"82","issue":"6","first_page":"2111","last_page":"2130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.550163209438324},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5248698592185974},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.4952644407749176},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.48064935207366943},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4459025263786316},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.44364750385284424},{"id":"https://openalex.org/keywords/maturity","display_name":"Maturity (psychological)","score":0.44247370958328247},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.41540849208831787},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.40457820892333984},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.396192729473114},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.3542090058326721},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3042095899581909},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2849099040031433},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.2799336314201355},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.25854039192199707},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25627267360687256},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19594722986221313}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.550163209438324},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5248698592185974},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4952644407749176},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.48064935207366943},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4459025263786316},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.44364750385284424},{"id":"https://openalex.org/C101433766","wikidata":"https://www.wikidata.org/wiki/Q3543263","display_name":"Maturity (psychological)","level":2,"score":0.44247370958328247},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.41540849208831787},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.40457820892333984},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.396192729473114},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3542090058326721},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3042095899581909},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2849099040031433},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.2799336314201355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25854039192199707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25627267360687256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19594722986221313},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1137/22m147668x","is_oa":false,"landing_page_url":"https://doi.org/10.1137/22m147668x","pdf_url":null,"source":{"id":"https://openalex.org/S77200987","display_name":"SIAM Journal on Applied Mathematics","issn_l":"0036-1399","issn":["0036-1399","1095-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Journal on Applied Mathematics","raw_type":"journal-article"},{"id":"pmh:oai:publications.rwth-aachen.de:974889","is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/974889","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM journal on applied mathematics 82(6), 2111-2130 (2022). doi:10.1137/22M147668X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W169626422","https://openalex.org/W183545005","https://openalex.org/W1239088256","https://openalex.org/W1635779336","https://openalex.org/W1968541727","https://openalex.org/W1977821962","https://openalex.org/W1977905227","https://openalex.org/W1990553788","https://openalex.org/W1992448994","https://openalex.org/W1998239597","https://openalex.org/W2009331316","https://openalex.org/W2013332168","https://openalex.org/W2022511877","https://openalex.org/W2023351030","https://openalex.org/W2029510277","https://openalex.org/W2034202604","https://openalex.org/W2036795046","https://openalex.org/W2037779659","https://openalex.org/W2039137515","https://openalex.org/W2060698840","https://openalex.org/W2062704276","https://openalex.org/W2063382772","https://openalex.org/W2065111801","https://openalex.org/W2077693542","https://openalex.org/W2093144236","https://openalex.org/W2102085111","https://openalex.org/W2102407330","https://openalex.org/W2105495977","https://openalex.org/W2112789125","https://openalex.org/W2120495395","https://openalex.org/W2127113067","https://openalex.org/W2138215603","https://openalex.org/W2150951349","https://openalex.org/W2262707985","https://openalex.org/W2602848567","https://openalex.org/W2610808603","https://openalex.org/W2793558578","https://openalex.org/W2807575667","https://openalex.org/W2889734305","https://openalex.org/W2902863200","https://openalex.org/W2915097886","https://openalex.org/W2949358790","https://openalex.org/W2950440927","https://openalex.org/W3041808241","https://openalex.org/W3102217092","https://openalex.org/W3102642837","https://openalex.org/W3103689510","https://openalex.org/W3130904297","https://openalex.org/W4200311413","https://openalex.org/W4236153851"],"related_works":["https://openalex.org/W2791617766","https://openalex.org/W2010501276","https://openalex.org/W2079838338","https://openalex.org/W2076802652","https://openalex.org/W2055314256","https://openalex.org/W3122869223","https://openalex.org/W3195146630","https://openalex.org/W4388401032","https://openalex.org/W1575119319","https://openalex.org/W2043671984"],"abstract_inverted_index":{".Production":[0],"of":[1,20,58,91,102,115,117,124,147,192],"blood":[2,24,27],"cells":[3,28,92,116,125],"is":[4,14,54,93,104,144],"a":[5,56,64,67,72,96,140,145,183,212],"complex":[6],"and":[7,47,135,186,226],"tightly":[8],"regulated":[9],"process.":[10,69,214],"Its":[11],"quantitative":[12],"understanding":[13],"highly":[15],"relevant":[16],"for":[17,112],"the":[18,32,88,113,122,131,148,154,157,160,187,224],"treatment":[19],"various":[21],"diseases,":[22],"including":[23],"cancers.":[25],"White":[26],"(WBCs)":[29],"originate":[30],"from":[31,121,223],"so-called":[33],"hematopoietic":[34],"stem":[35],"cell":[36,61,133,150],"(HSC)":[37],"population.":[38,151],"HSCs":[39],"give":[40],"rise":[41],"to":[42,78,231],"immature":[43],"WBCs":[44],"that":[45,110,217],"divide":[46],"further":[48],"differentiate":[49],"into":[50],"mature":[51,149],"cells.":[52],"It":[53],"still":[55],"matter":[57],"debate":[59],"whether":[60],"differentiation":[62,123,136,181,210],"resembles":[63],"discrete":[65,184],"or":[66],"continuous":[68,74,98,213],"We":[70,152,215],"propose":[71],"novel":[73],"integral":[75,108,235],"model":[76,165,191],"(CIM)":[77],"describe":[79],"WBC":[80],"production.":[81],"In":[82,130],"agreement":[83],"with":[84,126],"recent":[85],"experimental":[86],"results,":[87],"maturity":[89,118,128],"level":[90,119],"described":[94],"by":[95,106,139,196],"one-dimensional":[97],"variable.":[99],"The":[100],"process":[101],"maturation":[103],"modeled":[105],"an":[107],"term":[109],"accounts":[111],"influx":[114],"\\(x\\)":[120],"lower":[127],"levels.":[129],"model,":[132],"proliferation":[134],"are":[137],"controlled":[138],"feedback":[141],"signal":[142],"which":[143,179,208],"function":[146],"investigate":[153],"relationships":[155],"between":[156],"proposed":[158],"CIM,":[159],"multicompartment":[161],"ordinary":[162],"differential":[163,189],"equations":[164,190],"introduced":[166],"in":[167],"[A.":[168],"Marciniak-Czochra":[169],"et":[170,198],"al.,":[171],"Stem":[172],"Cells":[173],"Dev.,":[174],"18":[175],"(2009),":[176],"pp.":[177,206],"377\u2013385]":[178],"treats":[180],"as":[182,211],"process,":[185],"partial":[188],"transport":[193],"type":[194],"studied":[195],"Doumic":[197],"al.":[199],"[SIAM":[200],"J.":[201],"Appl.":[202],"Math.,":[203],"71":[204],"(2011),":[205],"1918\u20131940]":[207],"describes":[209],"show":[216],"both":[218],"models":[219],"can":[220],"be":[221],"derived":[222],"CIM":[225],"we":[227],"perform":[228],"numerical":[229],"simulations":[230],"compare":[232],"them":[233],"qualitatively.Keywordscontinuous":[234],"modelmulticompartment":[236],"ODE":[237],"modeltransport":[238],"modelhematopoiesisdifferentiationself-renewalMSC":[239],"codes35Q9245M0534A3035R0992C50":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}