{"id":"https://openalex.org/W3179951643","doi":"https://doi.org/10.1137/21m1433642","title":"A Diffuse Interface Model for Cell Blebbing Including Membrane-Cortex Coupling with Linker Dynamics","display_name":"A Diffuse Interface Model for Cell Blebbing Including Membrane-Cortex Coupling with Linker Dynamics","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W3179951643","doi":"https://doi.org/10.1137/21m1433642","mag":"3179951643"},"language":"en","primary_location":{"id":"doi:10.1137/21m1433642","is_oa":false,"landing_page_url":"https://doi.org/10.1137/21m1433642","pdf_url":null,"source":{"id":"https://openalex.org/S77200987","display_name":"SIAM Journal on Applied Mathematics","issn_l":"0036-1399","issn":["0036-1399","1095-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Journal on Applied Mathematics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086215751","display_name":"Philipp Werner","orcid":"https://orcid.org/0000-0002-2136-6568"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Werner","raw_affiliation_strings":["Department of Mathematics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069220813","display_name":"Martin Burger","orcid":"https://orcid.org/0000-0003-2619-2912"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Burger","raw_affiliation_strings":["Department of Mathematics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2619-2912","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069898231","display_name":"Florian Frank","orcid":"https://orcid.org/0000-0002-9756-1351"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Frank","raw_affiliation_strings":["Department of Mathematics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071758656","display_name":"Harald Garcke","orcid":"https://orcid.org/0000-0001-5235-2073"},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harald Garcke","raw_affiliation_strings":["Fakult\u00e4t f\u00fcr Mathematik, Universit\u00e4t Regensburg, 93040 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fakult\u00e4t f\u00fcr Mathematik, Universit\u00e4t Regensburg, 93040 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2282,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43872145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"82","issue":"3","first_page":"1091","last_page":"1112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11087","display_name":"Solidification and crystal growth phenomena","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.5879493355751038},{"id":"https://openalex.org/keywords/linker","display_name":"Linker","score":0.5526410937309265},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.5313347578048706},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5219449400901794},{"id":"https://openalex.org/keywords/bleb","display_name":"Bleb (medicine)","score":0.5183930993080139},{"id":"https://openalex.org/keywords/cell-cortex","display_name":"Cell cortex","score":0.5146325826644897},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.488491415977478},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4836955666542053},{"id":"https://openalex.org/keywords/cortex","display_name":"Cortex (anatomy)","score":0.44779065251350403},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.44333773851394653},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.43767374753952026},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3586028814315796},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.3419113755226135},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.33539125323295593},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.29806917905807495},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2825343608856201},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2652990221977234},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.22385141253471375},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.17547115683555603},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14682051539421082},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.1287722885608673}],"concepts":[{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5879493355751038},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5526410937309265},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5313347578048706},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5219449400901794},{"id":"https://openalex.org/C2776228307","wikidata":"https://www.wikidata.org/wiki/Q4925763","display_name":"Bleb (medicine)","level":4,"score":0.5183930993080139},{"id":"https://openalex.org/C204462481","wikidata":"https://www.wikidata.org/wiki/Q5058180","display_name":"Cell cortex","level":4,"score":0.5146325826644897},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.488491415977478},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4836955666542053},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.44779065251350403},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.44333773851394653},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.43767374753952026},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3586028814315796},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3419113755226135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33539125323295593},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29806917905807495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2825343608856201},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2652990221977234},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22385141253471375},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.17547115683555603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14682051539421082},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.1287722885608673},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C2777824320","wikidata":"https://www.wikidata.org/wiki/Q3177088","display_name":"Trabeculectomy","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1137/21m1433642","is_oa":false,"landing_page_url":"https://doi.org/10.1137/21m1433642","pdf_url":null,"source":{"id":"https://openalex.org/S77200987","display_name":"SIAM Journal on Applied Mathematics","issn_l":"0036-1399","issn":["0036-1399","1095-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Journal on Applied Mathematics","raw_type":"journal-article"},{"id":"pmh:oai:epub.uni-regensburg.de:57222","is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/57222/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3270504644","display_name":null,"funder_award_id":"RTG 2339","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1479756236","https://openalex.org/W1519094910","https://openalex.org/W1549664546","https://openalex.org/W1930237276","https://openalex.org/W1968102134","https://openalex.org/W1974938825","https://openalex.org/W1990541396","https://openalex.org/W2000545789","https://openalex.org/W2001060991","https://openalex.org/W2002365705","https://openalex.org/W2004703030","https://openalex.org/W2006605419","https://openalex.org/W2018573676","https://openalex.org/W2023339355","https://openalex.org/W2029177929","https://openalex.org/W2031826240","https://openalex.org/W2043879728","https://openalex.org/W2067257899","https://openalex.org/W2107436920","https://openalex.org/W2125813323","https://openalex.org/W2127375677","https://openalex.org/W2140592794","https://openalex.org/W2264936970","https://openalex.org/W2267555494","https://openalex.org/W2302695273","https://openalex.org/W2468082290","https://openalex.org/W2492922843","https://openalex.org/W2544116441","https://openalex.org/W2734371259","https://openalex.org/W2765105460","https://openalex.org/W2766907061","https://openalex.org/W2964017870","https://openalex.org/W2996100013","https://openalex.org/W2996293895","https://openalex.org/W3018176789","https://openalex.org/W3038000168","https://openalex.org/W3101441676","https://openalex.org/W4252603282"],"related_works":["https://openalex.org/W4224442507","https://openalex.org/W2043879728","https://openalex.org/W4387994562","https://openalex.org/W3011335604","https://openalex.org/W2049285713","https://openalex.org/W1919591201","https://openalex.org/W2041012485","https://openalex.org/W2070574906","https://openalex.org/W3131121226","https://openalex.org/W3005200848"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,13,21,28,51,66,82],"this":[3,37],"paper":[4],"is":[5],"to":[6,41,93],"develop":[7],"suitable":[8,64],"models":[9,84,125],"for":[10,18,62],"the":[11,25,29,33,53,56,67,74,83,127],"phenomenon":[12],"cell":[14,30],"blebbing,":[15],"which":[16,58,90,119],"allow":[17],"computational":[19,97],"predictions":[20],"mechanical":[22],"effects,":[23],"including":[24],"crucial":[26],"interaction":[27,68],"membrane":[31,54],"and":[32,55,85],"actin":[34],"cortex.":[35],"For":[36],"sake":[38],"we":[39,77,101],"resort":[40],"a":[42,63,87],"two":[43],"phase":[44],"field":[45],"model":[46],"that":[47,103],"uses":[48],"diffuse":[49],"descriptions":[50],"both":[52],"cortex,":[57],"in":[59,107,112],"particular":[60,113],"allows":[61,91],"description":[65],"via":[69],"linker":[70,128],"protein":[71],"densities.":[72],"Besides":[73],"detailed":[75],"modeling":[76],"discuss":[78],"some":[79],"energetic":[80],"aspects":[81],"present":[86],"numerical":[88],"scheme,":[89],"us":[92],"carry":[94],"out":[95],"several":[96,104],"studies.":[98],"In":[99],"those":[100],"demonstrate":[102],"effects":[105],"found":[106],"experiments":[108],"can":[109],"be":[110],"reproduced,":[111],"bleb":[114],"formation":[115],"by":[116,123],"cortex":[117],"rupture,":[118],"was":[120],"not":[121],"possible":[122],"previous":[124],"without":[126],"dynamics.":[129]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}