{"id":"https://openalex.org/W2775232909","doi":"https://doi.org/10.1137/17m1113503","title":"A Micro-Macro Framework for Analyzing Steric and Hydrodynamic Interactions in Gliding Assays","display_name":"A Micro-Macro Framework for Analyzing Steric and Hydrodynamic Interactions in Gliding Assays","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2775232909","doi":"https://doi.org/10.1137/17m1113503","mag":"2775232909"},"language":"en","primary_location":{"id":"doi:10.1137/17m1113503","is_oa":false,"landing_page_url":"https://doi.org/10.1137/17m1113503","pdf_url":null,"source":{"id":"https://openalex.org/S4357572","display_name":"Multiscale Modeling and Simulation","issn_l":"1540-3459","issn":["1540-3459","1540-3467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiscale Modeling & Simulation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021484753","display_name":"Steven Cook","orcid":null},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven C. Cook","raw_affiliation_strings":["University of California at Riverside"],"affiliations":[{"raw_affiliation_string":"University of California at Riverside","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013846215","display_name":"Christel Hohenegger","orcid":"https://orcid.org/0000-0003-2671-440X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christel Hohenegger","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086377660","display_name":"Tamar Shinar","orcid":"https://orcid.org/0000-0002-1383-9636"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamar Shinar","raw_affiliation_strings":["University of California at Riverside"],"affiliations":[{"raw_affiliation_string":"University of California at Riverside","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021484753"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15821181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"4","first_page":"1768","last_page":"1796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11486","display_name":"Micro and Nano Robotics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/3104","display_name":"Condensed Matter Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11486","display_name":"Micro and Nano Robotics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/3104","display_name":"Condensed Matter Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11751","display_name":"Lattice Boltzmann Simulation Studies","score":0.9524000287055969,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.9416000247001648,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motor-protein","display_name":"Motor protein","score":0.6535055637359619},{"id":"https://openalex.org/keywords/protein-filament","display_name":"Protein filament","score":0.6532377004623413},{"id":"https://openalex.org/keywords/steric-effects","display_name":"Steric effects","score":0.6244252324104309},{"id":"https://openalex.org/keywords/molecular-motor","display_name":"Molecular motor","score":0.5842419862747192},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5785344243049622},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.48232218623161316},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.455424964427948},{"id":"https://openalex.org/keywords/collective-behavior","display_name":"Collective behavior","score":0.4495837986469269},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.4396054446697235},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.43013542890548706},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3910284638404846},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3741942346096039},{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.3253380060195923},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32146957516670227},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.27886396646499634},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17257636785507202}],"concepts":[{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.6535055637359619},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.6532377004623413},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.6244252324104309},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.5842419862747192},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5785344243049622},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.48232218623161316},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.455424964427948},{"id":"https://openalex.org/C100339178","wikidata":"https://www.wikidata.org/wiki/Q2548752","display_name":"Collective behavior","level":2,"score":0.4495837986469269},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4396054446697235},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43013542890548706},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3910284638404846},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3741942346096039},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.3253380060195923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32146957516670227},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27886396646499634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17257636785507202},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1137/17m1113503","is_oa":false,"landing_page_url":"https://doi.org/10.1137/17m1113503","pdf_url":null,"source":{"id":"https://openalex.org/S4357572","display_name":"Multiscale Modeling and Simulation","issn_l":"1540-3459","issn":["1540-3459","1540-3467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiscale Modeling & Simulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1604523534","display_name":null,"funder_award_id":"R01GM104976","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332550","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1859038164","https://openalex.org/W1929380047","https://openalex.org/W1970459187","https://openalex.org/W1987252988","https://openalex.org/W1990987212","https://openalex.org/W1991634500","https://openalex.org/W1995664116","https://openalex.org/W1996305222","https://openalex.org/W2005751229","https://openalex.org/W2009634008","https://openalex.org/W2016085292","https://openalex.org/W2038953393","https://openalex.org/W2044371211","https://openalex.org/W2061837251","https://openalex.org/W2063843701","https://openalex.org/W2071243732","https://openalex.org/W2079137734","https://openalex.org/W2082818211","https://openalex.org/W2084131634","https://openalex.org/W2088626875","https://openalex.org/W2104741465","https://openalex.org/W2110961244","https://openalex.org/W2115378800","https://openalex.org/W2132183279","https://openalex.org/W2167127135","https://openalex.org/W2175246397","https://openalex.org/W2209140502","https://openalex.org/W3150224089"],"related_works":["https://openalex.org/W1990010457","https://openalex.org/W2327336249","https://openalex.org/W2039356149","https://openalex.org/W2141499882","https://openalex.org/W642093732","https://openalex.org/W1679408412","https://openalex.org/W2167320414","https://openalex.org/W2134981881","https://openalex.org/W2610327355","https://openalex.org/W204526712"],"abstract_inverted_index":{"Macroscopic":[0],"flows":[1],"of":[2,9,32,168],"filament-motor":[3],"mixtures,":[4],"driven":[5],"by":[6],"the":[7,28,71,90,144,152,166],"hydrolysis":[8],"ATP,":[10],"are":[11,68],"important":[12],"to":[13,51,70,142],"many":[14],"cellular":[15],"processes":[16],"such":[17,74],"as":[18,75,116,118],"cytoplasmic":[19],"streaming":[20],"in":[21,27,38,165],"Drosophila":[22],"oocytes":[23],"and":[24,52,63,79,92,104,121,134,139,173,182,184,188],"cortical":[25],"flow":[26,171],"first":[29],"cell":[30],"division":[31],"C.":[33],"elegans.":[34],"Gliding":[35],"assays,":[36],"reduced":[37],"vitro":[39],"model":[40,127],"systems":[41,67],"where":[42],"motor":[43,76,114,154],"proteins":[44],"adsorbed":[45],"onto":[46],"a":[47,86,101,163],"planar":[48],"substrate":[49],"bind":[50],"move":[53],"filaments,":[54],"recreate":[55],"large-scale":[56],"dynamic":[57],"patterns":[58],"like":[59],"coherent":[60,170],"swarming":[61],"motion":[62],"density":[64],"waves.":[65],"These":[66],"sensitive":[69],"microscopic":[72,113,153],"behavior":[73],"protein":[77,155],"binding":[78],"unbinding":[80],"dynamics,":[81],"which":[82],"take":[83],"place":[84],"on":[85,130],"faster":[87],"timescale":[88],"than":[89],"direct":[91],"fluid-mediated":[93],"filament":[94,180],"interactions.":[95],"In":[96],"this":[97],"work,":[98],"we":[99],"present":[100],"multiscale":[102],"modeling":[103,115],"simulation":[105],"framework":[106],"for":[107],"gliding":[108],"assays":[109],"that":[110,159],"allows":[111],"detailed":[112],"well":[117],"both":[119],"steric":[120,160],"hydrodynamic":[122],"interactions":[123,161],"between":[124],"filaments.":[125],"Our":[126],"is":[128],"based":[129],"continuum":[131],"kinetic":[132],"theory,":[133],"our":[135],"implementation":[136],"utilizes":[137],"CPU":[138],"GPU":[140],"parallelism":[141],"track":[143],"sparse":[145],"but":[146],"high-dimensional":[147],"state":[148],"space":[149],"arising":[150],"from":[151],"configurations.":[156],"We":[157],"find":[158],"play":[162],"role":[164],"formation":[167],"spatiotemporally":[169],"structures":[172],"qualitatively":[174],"reproduce":[175],"experimentally":[176],"observed":[177],"behaviors":[178],"including":[179],"crossover":[181],"alignment":[183],"clump":[185],"formation,":[186],"merging,":[187],"splitting.":[189]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}