{"id":"https://openalex.org/W2082198805","doi":"https://doi.org/10.1137/1035001","title":"Mathematical Models and the Design of Public Health Policy: Hiv and Antiviral Therapy","display_name":"Mathematical Models and the Design of Public Health Policy: Hiv and Antiviral Therapy","publication_year":1993,"publication_date":"1993-03-01","ids":{"openalex":"https://openalex.org/W2082198805","doi":"https://doi.org/10.1137/1035001","mag":"2082198805"},"language":"en","primary_location":{"id":"doi:10.1137/1035001","is_oa":false,"landing_page_url":"https://doi.org/10.1137/1035001","pdf_url":null,"source":{"id":"https://openalex.org/S160107561","display_name":"SIAM Review","issn_l":"0036-1445","issn":["0036-1445","1095-7200"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Review","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084340103","display_name":"Sunetra Gupta","orcid":"https://orcid.org/0000-0002-9775-4006"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunetra Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049396774","display_name":"Roy M. Anderson","orcid":"https://orcid.org/0000-0002-9528-3175"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy M. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080792075","display_name":"Robert M. May","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. May","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9201,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73762671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":"1","first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11860","display_name":"HIV, Drug Use, Sexual Risk","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11860","display_name":"HIV, Drug Use, Sexual Risk","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9779000282287598,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9706000089645386,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6338286995887756},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.6147540807723999},{"id":"https://openalex.org/keywords/basic-reproduction-number","display_name":"Basic reproduction number","score":0.6055346131324768},{"id":"https://openalex.org/keywords/homogeneous","display_name":"Homogeneous","score":0.5550037622451782},{"id":"https://openalex.org/keywords/sexual-transmission","display_name":"Sexual transmission","score":0.5044583082199097},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4911322295665741},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.4706506133079529},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4339006543159485},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.386660099029541},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3128126263618469},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2851771414279938},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.21193575859069824},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09300258755683899}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6338286995887756},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.6147540807723999},{"id":"https://openalex.org/C204264503","wikidata":"https://www.wikidata.org/wiki/Q901464","display_name":"Basic reproduction number","level":3,"score":0.6055346131324768},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.5550037622451782},{"id":"https://openalex.org/C3019340110","wikidata":"https://www.wikidata.org/wiki/Q525512","display_name":"Sexual transmission","level":4,"score":0.5044583082199097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4911322295665741},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4706506133079529},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4339006543159485},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.386660099029541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3128126263618469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2851771414279938},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.21193575859069824},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09300258755683899},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C197746943","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Microbicide","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1137/1035001","is_oa":false,"landing_page_url":"https://doi.org/10.1137/1035001","pdf_url":null,"source":{"id":"https://openalex.org/S160107561","display_name":"SIAM Review","issn_l":"0036-1445","issn":["0036-1445","1095-7200"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Review","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2009226722","https://openalex.org/W2016390392","https://openalex.org/W2062555652","https://openalex.org/W2079324401","https://openalex.org/W2086462809","https://openalex.org/W2087735159","https://openalex.org/W2111103957","https://openalex.org/W2151593978","https://openalex.org/W2318770038","https://openalex.org/W2333399282","https://openalex.org/W2412904997","https://openalex.org/W4256221661"],"related_works":["https://openalex.org/W3203556363","https://openalex.org/W2409550527","https://openalex.org/W2117573763","https://openalex.org/W2891673452","https://openalex.org/W2162810902","https://openalex.org/W4252452255","https://openalex.org/W4322708809","https://openalex.org/W2807719603","https://openalex.org/W2734055167","https://openalex.org/W2962832242"],"abstract_inverted_index":{"Antiviral":[0],"therapy":[1,97,201],"acting":[2],"to":[3,70,102,150,167,193,205],"increase":[4,16,40,52,108],"the":[5,17,30,46,54,72,75,78,83,89,103,110,129,143,151,162,165,168,194,198,212,226],"incubation":[6],"period":[7],"of":[8,19,26,32,43,57,68,82,100,112,118,145,153,155,164,170,172,200,211,218,229],"HIV-1,":[9],"without":[10],"significantly":[11],"reducing":[12],"infectiousness,":[13],"will":[14,66],"necessarily":[15],"prevalence":[18],"infection,":[20],"unless":[21],"accompanied":[22],"by":[23,50],"appropriate":[24],"levels":[25],"behaviour":[27],"change.":[28],"However,":[29,96],"number":[31,111],"AIDS-related":[33],"deaths":[34],"may":[35,98],"decline":[36],"despite":[37],"a":[38,62,116,136,177],"large":[39],"in":[41,53,109,180,190,223],"numbers":[42],"seropositives,":[44],"if":[45,77,128],"latter":[47],"is":[48,85,133,147,189,202],"balanced":[49],"an":[51,58,107],"average":[55],"life-span":[56],"infected":[59,234],"individual.":[60],"In":[61,135],"homogeneous":[63,195],"population,":[64],"treatment":[65,146,231],"be":[67,99,206],"benefit":[69],"both":[71],"individual":[73],"and":[74,91,122],"community":[76,104],"basic":[79,130,185,213],"reproductive":[80,131,186,214],"rate":[81,132,152,169],"disease":[84],"high,":[86],"provided":[87],"that":[88],"coverage":[90,124],"efficacy":[92,121],"are":[93,221],"also":[94],"high.":[95],"detriment":[101],"(i.e.,":[105],"produce":[106],"AIDS":[113],"deaths)":[114],"under":[115],"combination":[117],"low":[119],"drug":[120],"high":[123],"or":[125],"vice":[126],"versa,":[127],"low.":[134],"behaviourally":[137],"heterogeneous":[138],"population":[139,181],"with":[140,225,235],"proportionate":[141],"mixing,":[142],"outcome":[144,199],"extremely":[148],"sensitive":[149],"cessation":[154,171],"sexual":[156,173],"activity.":[157],"Within":[158],"certain":[159],"parameter":[160],"combinations,":[161],"sensitivity":[163],"system":[166],"activity":[174],"can":[175],"cause":[176],"larger":[178],"decrease":[179],"size":[182],"at":[183,208],"higher":[184,209],"rates.":[187],"This":[188],"direct":[191],"contrast":[192],"case,":[196],"where":[197],"less":[203],"likely":[204],"perverse":[207],"values":[210],"rate.":[215],"The":[216],"conclusions":[217],"this":[219],"paper":[220],"not":[222],"conflict":[224],"moral":[227],"imperative":[228],"providing":[230],"for":[232],"individuals":[233],"HIV.":[236]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}