{"id":"https://openalex.org/W1979018319","doi":"https://doi.org/10.1137/100815335","title":"A Computational Model of Cell Polarization and Motility Coupling Mechanics and Biochemistry","display_name":"A Computational Model of Cell Polarization and Motility Coupling Mechanics and Biochemistry","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W1979018319","doi":"https://doi.org/10.1137/100815335","mag":"1979018319","pmid":"https://pubmed.ncbi.nlm.nih.gov/22904684"},"language":"en","primary_location":{"id":"doi:10.1137/100815335","is_oa":false,"landing_page_url":"https://doi.org/10.1137/100815335","pdf_url":null,"source":{"id":"https://openalex.org/S4357572","display_name":"Multiscale Modeling and Simulation","issn_l":"1540-3459","issn":["1540-3459","1540-3467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiscale Modeling &amp; Simulation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085535083","display_name":"Ben Vanderlei","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ben Vanderlei","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014742621","display_name":"James J. Feng","orcid":"https://orcid.org/0000-0002-7141-5823"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Feng","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065805531","display_name":"Leah Edelstein\u2010Keshet","orcid":"https://orcid.org/0000-0002-2233-690X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leah Edelstein-Keshet","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085535083"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2285,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.76438446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"1420","last_page":"1443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polarization","display_name":"Polarization (electrochemistry)","score":0.5269520878791809},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5205477476119995},{"id":"https://openalex.org/keywords/bounded-function","display_name":"Bounded function","score":0.5054733753204346},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4818045496940613},{"id":"https://openalex.org/keywords/classical-mechanics","display_name":"Classical mechanics","score":0.47622400522232056},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.4559912383556366},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4251101016998291},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4107149839401245},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39256924390792847},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.37861815094947815},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.31369853019714355},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.27149081230163574},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23862957954406738},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.1873568892478943},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1368297040462494}],"concepts":[{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.5269520878791809},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5205477476119995},{"id":"https://openalex.org/C34388435","wikidata":"https://www.wikidata.org/wiki/Q2267362","display_name":"Bounded function","level":2,"score":0.5054733753204346},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4818045496940613},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.47622400522232056},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.4559912383556366},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4251101016998291},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4107149839401245},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39256924390792847},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.37861815094947815},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.31369853019714355},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.27149081230163574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23862957954406738},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1873568892478943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1368297040462494},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1137/100815335","is_oa":false,"landing_page_url":"https://doi.org/10.1137/100815335","pdf_url":null,"source":{"id":"https://openalex.org/S4357572","display_name":"Multiscale Modeling and Simulation","issn_l":"1540-3459","issn":["1540-3459","1540-3467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiscale Modeling &amp; Simulation","raw_type":"journal-article"},{"id":"pmid:22904684","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22904684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiscale modeling & simulation : a SIAM interdisciplinary journal","raw_type":null},{"id":"pmh:oai:europepmc.org:2422512","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3419594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2165548363","display_name":null,"funder_award_id":"Canada","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G3487555608","display_name":null,"funder_award_id":"R01 GM086882","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5784215521","display_name":null,"funder_award_id":"Chair","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320314005","display_name":"Western Canada Research Grid","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1952185161","https://openalex.org/W1975182211","https://openalex.org/W1977912657","https://openalex.org/W2008063578","https://openalex.org/W2011155152","https://openalex.org/W2012063891","https://openalex.org/W2017266862","https://openalex.org/W2017278112","https://openalex.org/W2019142176","https://openalex.org/W2045277539","https://openalex.org/W2046313315","https://openalex.org/W2051413099","https://openalex.org/W2055882856","https://openalex.org/W2057858884","https://openalex.org/W2060291257","https://openalex.org/W2063993190","https://openalex.org/W2070851978","https://openalex.org/W2084131634","https://openalex.org/W2093243363","https://openalex.org/W2102723402","https://openalex.org/W2103247257","https://openalex.org/W2106479217","https://openalex.org/W2115301507","https://openalex.org/W2124405153","https://openalex.org/W2129339706","https://openalex.org/W2133493253","https://openalex.org/W2141932305","https://openalex.org/W2146167520","https://openalex.org/W2153239426","https://openalex.org/W2154568995","https://openalex.org/W2156850808","https://openalex.org/W2162689493","https://openalex.org/W2163730390","https://openalex.org/W2188659719","https://openalex.org/W2494241247"],"related_works":["https://openalex.org/W2136053165","https://openalex.org/W2042726902","https://openalex.org/W1970859326","https://openalex.org/W2018828049","https://openalex.org/W1598979804","https://openalex.org/W3102909640","https://openalex.org/W2046712581","https://openalex.org/W2370340664","https://openalex.org/W1978402756","https://openalex.org/W2760970427"],"abstract_inverted_index":{"The":[0,22,60],"motion":[1,50,201],"of":[2,9,44,51,58,76,86,91,100,128,135,141,156,169,189,196,202,205],"a":[3,7,16,19,101,115,129],"eukaryotic":[4],"cell":[5,53,162,190],"presents":[6],"variety":[8],"interesting":[10],"and":[11,18,46,49,131,158,179,200],"challenging":[12],"problems":[13],"from":[14],"both":[15],"modeling":[17],"computational":[20,61,102,147],"perspective.":[21],"processes":[23],"span":[24],"many":[25],"spatial":[26],"scales":[27],"(from":[28],"molecular":[29],"to":[30,109,152],"tissue)":[31],"as":[32,34],"well":[33],"disparate":[35],"time":[36],"scales,":[37],"with":[38],"reaction":[39],"kinetics":[40],"on":[41,55,161,164,176],"the":[42,47,52,56,68,71,98,105,126,133,139,154,167,170,180,197],"order":[43,57],"seconds,":[45],"deformation":[48],"occurring":[54],"minutes.":[59],"difficulty,":[62],"even":[63],"in":[64,67,173],"2D,":[65],"resides":[66],"fact":[69],"that":[70,119,186],"problem":[72],"is":[73,89],"inherently":[74],"one":[75],"deforming,":[77],"non-stationary":[78],"domains,":[79],"bounded":[80],"by":[81],"an":[82,121],"elastic":[83,143,159],"perimeter,":[84],"inside":[85],"which":[87],"there":[88],"redistribution":[90],"biochemical":[92],"signaling":[93],"substances.":[94],"Here":[95],"we":[96,149],"report":[97],"results":[99],"scheme":[103,148],"using":[104],"immersed":[106],"boundary":[107],"method":[108],"address":[110],"this":[111,146,187],"problem.":[112],"We":[113,184],"adopt":[114],"simple":[116],"reaction-diffusion":[117,171],"system":[118,172],"represents":[120],"internal":[122],"regulatory":[123],"mechanism":[124],"controlling":[125],"polarization":[127,199],"cell,":[130],"determining":[132],"strength":[134],"protrusion":[136],"forces":[137,160],"at":[138],"front":[140],"its":[142,177],"perimeter.":[144],"Using":[145],"are":[150],"able":[151],"study":[153],"effect":[155],"protrusive":[157],"shapes":[163],"their":[165],"own,":[166,178],"distribution":[168],"irregular":[174],"domains":[175],"coupled":[181],"mechanical-chemical":[182],"system.":[183],"find":[185],"representation":[188],"crawling":[191,206],"can":[192],"recover":[193],"important":[194],"aspects":[195],"spontaneous":[198],"certain":[203],"types":[204],"cells.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-03-16T09:10:04.655348","created_date":"2025-10-10T00:00:00"}
