{"id":"https://openalex.org/W1998239597","doi":"https://doi.org/10.1137/050640072","title":"Bifurcation and Bistability in a Model of Hematopoietic Regulation","display_name":"Bifurcation and Bistability in a Model of Hematopoietic Regulation","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1998239597","doi":"https://doi.org/10.1137/050640072","mag":"1998239597"},"language":"en","primary_location":{"id":"doi:10.1137/050640072","is_oa":false,"landing_page_url":"https://doi.org/10.1137/050640072","pdf_url":null,"source":{"id":"https://openalex.org/S161160597","display_name":"SIAM Journal on Applied Dynamical Systems","issn_l":"1536-0040","issn":["1536-0040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Journal on Applied Dynamical Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091754800","display_name":"Caroline Colijn","orcid":"https://orcid.org/0000-0001-6097-6708"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Caroline Colijn","raw_affiliation_strings":["Department of Engineering Mathematics"],"affiliations":[{"raw_affiliation_string":"Department of Engineering Mathematics","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026791955","display_name":"Michael C. Mackey","orcid":"https://orcid.org/0000-0002-8524-2396"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Mackey","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091754800"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6338,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84497078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"2","first_page":"378","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.6584857106208801},{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.6444521546363831},{"id":"https://openalex.org/keywords/hopf-bifurcation","display_name":"Hopf bifurcation","score":0.5781134963035583},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.5340802669525146},{"id":"https://openalex.org/keywords/neutropenia","display_name":"Neutropenia","score":0.527228593826294},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.4223966598510742},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.37367963790893555},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.356136292219162},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3461052179336548},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3274821937084198},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.28012901544570923},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23243364691734314},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.09227690100669861}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6584857106208801},{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.6444521546363831},{"id":"https://openalex.org/C172435161","wikidata":"https://www.wikidata.org/wiki/Q531126","display_name":"Hopf bifurcation","level":4,"score":0.5781134963035583},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5340802669525146},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.527228593826294},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.4223966598510742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37367963790893555},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.356136292219162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3461052179336548},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3274821937084198},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28012901544570923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23243364691734314},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09227690100669861},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1137/050640072","is_oa":false,"landing_page_url":"https://doi.org/10.1137/050640072","pdf_url":null,"source":{"id":"https://openalex.org/S161160597","display_name":"SIAM Journal on Applied Dynamical Systems","issn_l":"1536-0040","issn":["1536-0040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320508","host_organization_name":"Society for Industrial and Applied Mathematics","host_organization_lineage":["https://openalex.org/P4310320508"],"host_organization_lineage_names":["Society for Industrial and Applied Mathematics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SIAM Journal on Applied Dynamical Systems","raw_type":"journal-article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/8464a848-0dbd-441a-b994-6d1005f09d65","is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/8464a848-0dbd-441a-b994-6d1005f09d65","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colijn, C G & Mackey, M 2007, 'Bifurcation and bistability in a model of hematopoietic regulation', SIAM Journal on Applied Dynamical Systems, vol. 6 (2), pp. 378 - 394. https://doi.org/10.1137/050640072","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.88.3174","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.88.3174","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cnd.mcgill.ca/bios/mackey/pdf_pub/bifurcation_2005.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W117470475","https://openalex.org/W120567373","https://openalex.org/W157103782","https://openalex.org/W1987233115","https://openalex.org/W1997133147","https://openalex.org/W1997942538","https://openalex.org/W2009664834","https://openalex.org/W2019584977","https://openalex.org/W2048017269","https://openalex.org/W2061239988","https://openalex.org/W2065111801","https://openalex.org/W2094184598","https://openalex.org/W2096885361","https://openalex.org/W2099806516","https://openalex.org/W2119584141","https://openalex.org/W2125987139","https://openalex.org/W2132954098","https://openalex.org/W2148972050","https://openalex.org/W2157583341","https://openalex.org/W2165438231","https://openalex.org/W2197012898","https://openalex.org/W2298997654","https://openalex.org/W2339183564","https://openalex.org/W2410712814","https://openalex.org/W2429907461","https://openalex.org/W4246713710"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W3118640947","https://openalex.org/W1964519618","https://openalex.org/W1969697984","https://openalex.org/W3048730783","https://openalex.org/W1992416820","https://openalex.org/W3094197880","https://openalex.org/W2183786486","https://openalex.org/W2042003698","https://openalex.org/W3099032440"],"abstract_inverted_index":{"Stem":[0],"cells":[1],"and":[2,34,52,61,181],"their":[3],"relationship":[4],"with":[5],"mature":[6],"tissues":[7],"are":[8,23],"of":[9,19,38,42,48,68,77,98,115,148,158,165],"increasing":[10],"interest":[11],"in":[12,89,108,151,188,197],"the":[13,17,36,56,69,75,78,95,119,123,152,169,189,194,198],"biomedical":[14],"sciences,":[15],"but":[16],"dynamics":[18,37],"stem":[20,31],"cell/tissue":[21,32],"interactions":[22],"not":[24,202],"well":[25],"understood.":[26],"We":[27,54,73],"give":[28,83],"a":[29,39,45,102,126,186],"generic":[30],"model":[33,47,112],"examine":[35],"specific":[40],"case":[41],"this,":[43],"namely,":[44],"four-compartment":[46],"blood":[49,70,86],"cell":[50,87],"production":[51,71],"regulation.":[53],"apply":[55],"findings":[57],"to":[58,82,85,121],"cyclical":[59,106],"neutropenia":[60],"periodic":[62,116],"chronic":[63],"myelogenous":[64],"leukemia,":[65],"two":[66],"diseases":[67,179],"system.":[72],"track":[74],"position":[76],"Hopf":[79],"bifurcation":[80],"believed":[81],"rise":[84],"oscillations":[88,140,175],"these":[90],"diseases.":[91],"Results":[92],"account":[93],"for":[94,105],"variable":[96],"success":[97],"granulocyte-colony":[99],"stimulating":[100],"factor,":[101],"common":[103],"treatment":[104],"neutropenia,":[107],"reducing":[109],"oscillations.":[110,170,205],"The":[111,155],"displays":[113],"bistability":[114],"solutions,":[117],"presenting":[118],"opportunity":[120],"stabilize":[122],"system":[124],"through":[125],"temporary":[127,163],"perturbation":[128],"that":[129,139,162,176,192],"induces":[130],"switching":[131],"between":[132],"locally":[133],"stable":[134],"solutions.":[135],"It":[136],"is":[137,161,173,184],"found":[138],"can":[141],"be":[142],"suppressed":[143],"by":[144],"properly":[145],"timed":[146],"pulses":[147,196],"increased":[149],"amplification":[150,200],"platelet":[153],"line.":[154],"medical":[156],"interpretation":[157],"this":[159],"result":[160],"administration":[164],"thrombopoietin":[166],"may":[167],"suppress":[168,204],"Though":[171],"it":[172,183],"neutrophil":[174,190,199],"characterize":[177],"both":[178],"clinically,":[180],"though":[182],"probably":[185],"destabilization":[187],"line":[191],"initiates":[193],"oscillations,":[195],"do":[201],"effectively":[203]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
