{"id":"https://openalex.org/W2156400232","doi":"https://doi.org/10.1136/amiajnl-2014-003043","title":"Choosing blindly but wisely: differentially private solicitation of DNA datasets for disease marker discovery","display_name":"Choosing blindly but wisely: differentially private solicitation of DNA datasets for disease marker discovery","publication_year":2014,"publication_date":"2014-10-28","ids":{"openalex":"https://openalex.org/W2156400232","doi":"https://doi.org/10.1136/amiajnl-2014-003043","mag":"2156400232","pmid":"https://pubmed.ncbi.nlm.nih.gov/25352565"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2014-003043","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2014-003043","pdf_url":"https://academic.oup.com/jamia/article-pdf/22/1/100/34145394/amiajnl-2014-003043.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jamia/article-pdf/22/1/100/34145394/amiajnl-2014-003043.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048904646","display_name":"Yongan Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yongan Zhao","raw_affiliation_strings":["Indiana University, Bloomington, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, Bloomington, Indiana, USA","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333259","display_name":"Xiaofeng Wang","orcid":"https://orcid.org/0000-0003-0091-3865"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Wang","raw_affiliation_strings":["Indiana University, Bloomington, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, Bloomington, Indiana, USA","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055458864","display_name":"Xiaoqian Jiang","orcid":"https://orcid.org/0000-0001-9933-2205"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqian Jiang","raw_affiliation_strings":["University of California, San Diego (UCSD), San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego (UCSD), San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084415954","display_name":"Lucila Ohno\u2010Machado","orcid":"https://orcid.org/0000-0002-8005-7327"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucila Ohno-Machado","raw_affiliation_strings":["University of California, San Diego (UCSD), San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego (UCSD), San Diego, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078007096","display_name":"Haixu Tang","orcid":"https://orcid.org/0000-0001-8963-8155"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haixu Tang","raw_affiliation_strings":["Indiana University, Bloomington, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University, Bloomington, Indiana, USA","institution_ids":["https://openalex.org/I4210119109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5048904646"],"corresponding_institution_ids":["https://openalex.org/I4210119109"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":{"value":3967,"currency":"USD","value_usd":3967},"fwci":4.6506,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.95082457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"100","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.8546000123023987,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.8546000123023987,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10237","display_name":"Cryptography and Data Security","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7887824773788452},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5245309472084045},{"id":"https://openalex.org/keywords/publication","display_name":"Publication","score":0.48975348472595215},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.45357266068458557},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4460681676864624},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4111090302467346},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3888033926486969},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.35707566142082214},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16921207308769226}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7887824773788452},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5245309472084045},{"id":"https://openalex.org/C41458344","wikidata":"https://www.wikidata.org/wiki/Q732577","display_name":"Publication","level":2,"score":0.48975348472595215},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.45357266068458557},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4460681676864624},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4111090302467346},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3888033926486969},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.35707566142082214},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16921207308769226},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C112698675","wikidata":"https://www.wikidata.org/wiki/Q37038","display_name":"Advertising","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/amiajnl-2014-003043","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2014-003043","pdf_url":"https://academic.oup.com/jamia/article-pdf/22/1/100/34145394/amiajnl-2014-003043.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:25352565","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25352565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4433380","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4433380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2014-003043","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2014-003043","pdf_url":"https://academic.oup.com/jamia/article-pdf/22/1/100/34145394/amiajnl-2014-003043.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.47999998927116394,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W136270404","https://openalex.org/W1550434518","https://openalex.org/W1589421353","https://openalex.org/W1873763122","https://openalex.org/W1965806321","https://openalex.org/W1985812501","https://openalex.org/W1987390807","https://openalex.org/W1992735538","https://openalex.org/W2009588715","https://openalex.org/W2040228409","https://openalex.org/W2047958782","https://openalex.org/W2072100938","https://openalex.org/W2095272373","https://openalex.org/W2104093114","https://openalex.org/W2110868467","https://openalex.org/W2121627353","https://openalex.org/W2134783591","https://openalex.org/W2135046866","https://openalex.org/W2138020005","https://openalex.org/W2141481372","https://openalex.org/W2150092391","https://openalex.org/W2150264698","https://openalex.org/W2152664025","https://openalex.org/W2164628101","https://openalex.org/W2168508553","https://openalex.org/W2463259285","https://openalex.org/W2911978475","https://openalex.org/W4210774750","https://openalex.org/W4211164083","https://openalex.org/W4285719527","https://openalex.org/W6605475529","https://openalex.org/W6639246211","https://openalex.org/W6682377967"],"related_works":["https://openalex.org/W4390608645","https://openalex.org/W4247566972","https://openalex.org/W2027108423","https://openalex.org/W1855666948","https://openalex.org/W2758561209","https://openalex.org/W1548095260","https://openalex.org/W2594414941","https://openalex.org/W2781711915","https://openalex.org/W2112817590","https://openalex.org/W1555291398"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"propose":[2],"a":[3,35,43,59,63,69,97,167],"new":[4,66],"approach":[5,72,123,140,185],"to":[6,29,55,82,176,179,190,193],"privacy":[7,92],"preserving":[8],"data":[9,14,32,44,57,89,111,128,143,157,180,188],"selection,":[10],"which":[11,42,171],"helps":[12,102],"the":[13,56,75,79,85,88,91,94,103,106,109,138,146,155,186,194],"users":[15,144],"access":[16,192],"human":[17,80,126],"genomic":[18,127],"datasets":[19,172],"efficiently":[20],"without":[21],"undermining":[22],"patients'":[23],"privacy.":[24],"METHODS:":[25],"Our":[26,134],"idea":[27],"is":[28],"let":[30],"each":[31],"owner":[33,58],"publish":[34],"set":[36],"of":[37,65,87,93,108,170],"differentially-private":[38],"pilot":[39,114,156],"data,":[40],"on":[41,124],"user":[45,104],"can":[46,141,183],"test-run":[47],"arbitrary":[48],"association-test":[49],"algorithms,":[50],"including":[51,68],"those":[52],"not":[53],"known":[54],"priori.":[60],"We":[61,120],"developed":[62],"suite":[64],"techniques,":[67],"pilot-data":[70],"generation":[71],"that":[73,101,137],"leverages":[74],"linkage":[76],"disequilibrium":[77],"in":[78,149],"genome":[81],"preserve":[83],"both":[84],"utility":[86,98],"and":[90,96],"patients,":[95],"evaluation":[99],"method":[100],"assess":[105],"value":[107],"real":[110,125],"from":[112],"its":[113],"version":[115],"with":[116],"high":[117],"confidence.":[118],"RESULTS:":[119],"evaluated":[121],"our":[122],"using":[129],"four":[130],"popular":[131],"association":[132],"tests.":[133],"study":[135],"shows":[136],"proposed":[139],"help":[142],"make":[145],"right":[147],"choices":[148],"most":[150],"cases.":[151],"CONCLUSIONS:":[152],"Even":[153],"though":[154],"cannot":[158],"be":[159,177],"directly":[160],"used":[161],"for":[162],"scientific":[163],"discovery,":[164],"it":[165],"provides":[166],"useful":[168,178],"indication":[169],"are":[173],"more":[174],"likely":[175],"users,":[181],"who":[182],"therefore":[184],"appropriate":[187],"owners":[189],"gain":[191],"data.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}