{"id":"https://openalex.org/W1884291487","doi":"https://doi.org/10.1136/amiajnl-2013-002519","title":"\u2018N-of-1-<i>pathways</i>\u2019 unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine","display_name":"\u2018N-of-1-<i>pathways</i>\u2019 unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine","publication_year":2014,"publication_date":"2014-06-13","ids":{"openalex":"https://openalex.org/W1884291487","doi":"https://doi.org/10.1136/amiajnl-2013-002519","mag":"1884291487","pmid":"https://pubmed.ncbi.nlm.nih.gov/25301808"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2013-002519","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2013-002519","pdf_url":"https://academic.oup.com/jamia/article-pdf/21/6/1015/17375720/21-6-1015.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jamia/article-pdf/21/6/1015/17375720/21-6-1015.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071438373","display_name":"Vincent Gardeux","orcid":"https://orcid.org/0000-0001-8954-2161"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210142324","display_name":"CY Cergy Paris Universit\u00e9","ror":"https://ror.org/043htjv09","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210142324"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Vincent Gardeux","raw_affiliation_strings":["Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Department of Informatics, School of Engineering, EISTI (\u00c9cole Internationale des Sciences du Traitement de l'Information), Cergy-Pontoise, France Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","Department of Informatics, School of Engineering, EISTI (\u00c9cole Internationale des Sciences du Traitement de l'Information), Cergy-Pontoise, France","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Department of Informatics, School of Engineering, EISTI (\u00c9cole Internationale des Sciences du Traitement de l'Information), Cergy-Pontoise, France Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238","https://openalex.org/I4210142324"]},{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Informatics, School of Engineering, EISTI (\u00c9cole Internationale des Sciences du Traitement de l'Information), Cergy-Pontoise, France","institution_ids":["https://openalex.org/I4210142324"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070645277","display_name":"Ikbel Achour","orcid":"https://orcid.org/0000-0001-6103-4069"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikbel Achour","raw_affiliation_strings":["Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627205","display_name":"Jianrong Li","orcid":"https://orcid.org/0000-0002-8232-9322"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianrong Li","raw_affiliation_strings":["Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051236191","display_name":"Mark Maienschein\u2010Cline","orcid":"https://orcid.org/0000-0001-6619-6788"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Maienschein-Cline","raw_affiliation_strings":["Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066737474","display_name":"Haiquan Li","orcid":"https://orcid.org/0000-0002-8049-0278"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiquan Li","raw_affiliation_strings":["Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048354436","display_name":"Lorenzo L. Pesce","orcid":"https://orcid.org/0000-0002-8015-4653"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Pesce","raw_affiliation_strings":["Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA","Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA. http://orcid.org/0000-0002-8015-4653"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1282105669"]},{"raw_affiliation_string":"Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA. http://orcid.org/0000-0002-8015-4653","institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015326776","display_name":"Gurunadh Parinandi","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gurunadh Parinandi","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004793396","display_name":"Neil Bahroos","orcid":"https://orcid.org/0000-0002-6522-1213"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Bahroos","raw_affiliation_strings":["Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009183159","display_name":"Robert A. Winn","orcid":"https://orcid.org/0000-0001-5948-9291"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Winn","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA University of Illinois Cancer Center, Chicago, Illinois, USA","University of Illinois Cancer Center, Chicago, Illinois, USA","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA University of Illinois Cancer Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois Cancer Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032231503","display_name":"Ian Foster","orcid":"https://orcid.org/0000-0003-2129-5269"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Foster","raw_affiliation_strings":["Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA Department of Computer Science, University of Chicago, Chicago, Illinois, USA Mathematics and Computer Science Division, Argonne National Laboratory, Chicago, Illinois, USA","Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA. http://orcid.org/0000-0002-8015-4653","Department of Computer Science, University of Chicago, Chicago, Illinois, USA","Mathematics and Computer Science Division, Argonne National Laboratory, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA Department of Computer Science, University of Chicago, Chicago, Illinois, USA Mathematics and Computer Science Division, Argonne National Laboratory, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1282105669"]},{"raw_affiliation_string":"Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA. http://orcid.org/0000-0002-8015-4653","institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Computer Science, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Mathematics and Computer Science Division, Argonne National Laboratory, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052491243","display_name":"Joe G. N. Garcia","orcid":"https://orcid.org/0000-0002-6934-0420"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe G N Garcia","raw_affiliation_strings":["Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074706648","display_name":"Yves A. Lussier","orcid":"https://orcid.org/0000-0001-9854-1005"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yves A Lussier","raw_affiliation_strings":["Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA University of Illinois Cancer Center, Chicago, Illinois, USA Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA Department of Biopharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Illinois, USA Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA","Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Biopharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Illinois, USA","Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA. http://orcid.org/0000-0002-8015-4653","Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA","Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA","Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","University of Illinois Cancer Center, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA University of Illinois Cancer Center, Chicago, Illinois, USA Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA Department of Biopharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Illinois, USA Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Biopharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA. http://orcid.org/0000-0002-8015-4653","institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"University of Illinois Cancer Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074706648"],"corresponding_institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I138006243","https://openalex.org/I39422238","https://openalex.org/I40347166"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":{"value":3967,"currency":"USD","value_usd":3967},"fwci":4.2157,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.94238833,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"6","first_page":"1015","last_page":"1025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.6086999773979187,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.6086999773979187,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.14489999413490295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.6904789805412292},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5604267120361328},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5263011455535889},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.4869126081466675},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4184896647930145},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3245261311531067},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28471484780311584},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.16398310661315918},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1254490315914154},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11793428659439087}],"concepts":[{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.6904789805412292},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5604267120361328},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5263011455535889},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4869126081466675},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4184896647930145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3245261311531067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28471484780311584},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.16398310661315918},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1254490315914154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11793428659439087}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/amiajnl-2013-002519","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2013-002519","pdf_url":"https://academic.oup.com/jamia/article-pdf/21/6/1015/17375720/21-6-1015.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:25301808","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25301808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:osti.gov:1225365","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1225365","pdf_url":"https://www.osti.gov/servlets/purl/1225365","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:europepmc.org:3186796","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4215042","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2013-002519","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2013-002519","pdf_url":"https://academic.oup.com/jamia/article-pdf/21/6/1015/17375720/21-6-1015.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2180208264","display_name":null,"funder_award_id":"UL1TR000050","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2361855714","display_name":null,"funder_award_id":"1S10RR029030-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2370975169","display_name":null,"funder_award_id":"S10 RR029030","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3408232842","display_name":null,"funder_award_id":"K22LM008308","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G576625284","display_name":null,"funder_award_id":"UL1TR000050","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G7036715501","display_name":null,"funder_award_id":"UL1 TR000050","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G7972181056","display_name":null,"funder_award_id":"K22 LM008308","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8640840829","display_name":null,"funder_award_id":"K22LM008308","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337990","display_name":"Cancer Center, University of Illinois at Chicago","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1884291487.pdf","grobid_xml":"https://content.openalex.org/works/W1884291487.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W82951121","https://openalex.org/W143101809","https://openalex.org/W1236321187","https://openalex.org/W1515242458","https://openalex.org/W1556470833","https://openalex.org/W1597454894","https://openalex.org/W1943785122","https://openalex.org/W1966029043","https://openalex.org/W1975974067","https://openalex.org/W1981509058","https://openalex.org/W1983943352","https://openalex.org/W1989532420","https://openalex.org/W1999119052","https://openalex.org/W2008529876","https://openalex.org/W2013178875","https://openalex.org/W2026011470","https://openalex.org/W2035559941","https://openalex.org/W2039310579","https://openalex.org/W2045883724","https://openalex.org/W2063841568","https://openalex.org/W2077836479","https://openalex.org/W2080878755","https://openalex.org/W2103017472","https://openalex.org/W2103184242","https://openalex.org/W2106108075","https://openalex.org/W2116019981","https://openalex.org/W2117446594","https://openalex.org/W2118019849","https://openalex.org/W2123879591","https://openalex.org/W2124211545","https://openalex.org/W2130410032","https://openalex.org/W2133197025","https://openalex.org/W2143654815","https://openalex.org/W2145259857","https://openalex.org/W2150528213","https://openalex.org/W2154947819","https://openalex.org/W2166273484","https://openalex.org/W2737630660"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4394426846","https://openalex.org/W4200033037","https://openalex.org/W4394543623","https://openalex.org/W4200407670","https://openalex.org/W3213655218","https://openalex.org/W4394560977","https://openalex.org/W3037909725","https://openalex.org/W2147993839","https://openalex.org/W4394488504"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,203],"emergence":[2],"of":[3,9,116,126,182,188,196,214],"precision":[4],"medicine":[5],"allowed":[6],"the":[7,72,90,123,180],"incorporation":[8],"individual":[10,23,159,215],"molecular":[11,58,165],"data":[12],"into":[13,111],"patient":[14,106],"care.":[15],"Indeed,":[16],"DNA":[17,170],"sequencing":[18],"predicts":[19,122],"somatic":[20],"mutations":[21],"in":[22,148,222],"patients.":[24],"However,":[25],"these":[26],"genetic":[27],"features":[28],"overlook":[29],"dynamic":[30],"epigenetic":[31],"and":[32,93,100,103,141,154,160,210],"phenotypic":[33],"response":[34],"to":[35,166,186],"therapy.":[36],"Meanwhile,":[37],"accurate":[38],"personal":[39],"transcriptome":[40],"interpretation":[41,213],"remains":[42],"an":[43,189],"unmet":[44],"challenge.":[45],"Further,":[46],"N-of-1":[47,236],"(single-subject)":[48],"efficacy":[49],"trials":[50],"are":[51,55,109],"increasingly":[52],"pursued,":[53],"but":[54],"underpowered":[56],"for":[57],"marker":[59],"discovery.":[60],"METHOD:":[61],"'N-of-1-pathways'":[62],"is":[63,75,81,219],"a":[64,76,207],"global":[65],"framework":[66,205],"relying":[67],"on":[68,179],"three":[69,149],"principles:":[70],"(i)":[71],"statistical":[73,209],"universe":[74],"single":[77],"patient;":[78,92],"(ii)":[79],"significance":[80],"derived":[82],"from":[83,89,164],"geneset/biomodules":[84],"powered":[85],"by":[86],"paired":[87],"samples":[88],"same":[91],"(iii)":[94],"similarity":[95,181],"between":[96],"genesets/biomodules":[97],"assesses":[98],"commonality":[99],"differences,":[101],"within-study":[102],"cross-studies.":[104],"Thus,":[105],"gene-level":[107],"profiles":[108],"transformed":[110],"deregulated":[112,124,184],"pathways.":[113],"From":[114],"RNA-Seq":[115],"55":[117],"lung":[118],"adenocarcinoma":[119],"patients,":[120],"N-of-1-pathways":[121,131,204],"pathways":[125],"each":[127],"patient.":[128],"RESULTS:":[129],"Cross-patient":[130],"obtains":[132],"comparable":[133],"results":[134],"with":[135,230],"conventional":[136,223],"genesets":[137],"enrichment":[138],"analysis":[139],"(GSEA)":[140],"differentially":[142],"expressed":[143],"gene":[144],"(DEG)":[145],"enrichment,":[146],"validated":[147],"external":[150],"evaluations.":[151],"Moreover,":[152],"heatmap":[153],"star":[155],"plots":[156],"highlight":[157],"both":[158],"shared":[161],"mechanisms":[162,185],"ranging":[163],"organ-systems":[167],"levels":[168],"(eg,":[169],"repair,":[171],"signaling,":[172],"immune":[173],"response).":[174],"Patients":[175],"were":[176],"ranked":[177],"based":[178],"their":[183],"those":[187],"independent":[190],"gold":[191],"standard,":[192],"generating":[193],"unsupervised":[194],"clusters":[195],"diametric":[197],"extreme":[198],"survival":[199,217],"phenotypes":[200],"(p=0.03).":[201],"CONCLUSIONS:":[202],"provides":[206],"robust":[208],"relevant":[211],"biological":[212],"disease-free":[216],"that":[218],"often":[220],"overlooked":[221],"cross-patient":[224],"studies.":[225,237],"It":[226],"enables":[227],"mechanism-level":[228],"classifiers":[229],"smaller":[231],"cohorts":[232],"as":[233,235],"well":[234],"SOFTWARE:":[238],"http://lussierlab.org/publications/N-of-1-pathways.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2016-06-24T00:00:00"}