{"id":"https://openalex.org/W2256225122","doi":"https://doi.org/10.1136/amiajnl-2013-001700","title":"Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds","display_name":"Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds","publication_year":2013,"publication_date":"2013-06-12","ids":{"openalex":"https://openalex.org/W2256225122","doi":"https://doi.org/10.1136/amiajnl-2013-001700","mag":"2256225122","pmid":"https://pubmed.ncbi.nlm.nih.gov/23757409"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2013-001700","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2013-001700","pdf_url":"https://academic.oup.com/jamia/article-pdf/21/2/238/17375606/21-2-238.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jamia/article-pdf/21/2/238/17375606/21-2-238.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014242942","display_name":"Adam Sateriale","orcid":"https://orcid.org/0000-0001-8947-2714"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Sateriale","raw_affiliation_strings":["Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040358222","display_name":"Kovi Bessoff","orcid":"https://orcid.org/0000-0002-5626-4027"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kovi Bessoff","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086602697","display_name":"Indra Neil Sarkar","orcid":"https://orcid.org/0000-0003-2054-7356"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indra Neil Sarkar","raw_affiliation_strings":["Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA","Center for Clinical and Translational Science, University of Vermont College of Medicine, Burlington, Vermont, USA","Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Center for Clinical and Translational Science, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005985454","display_name":"Christopher D. Huston","orcid":"https://orcid.org/0000-0002-5393-139X"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher D Huston","raw_affiliation_strings":["Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA","Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA","Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell, Molecular, and Biomedical Sciences Graduate Program, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005985454"],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":1.3763,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.81075812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"21","issue":"2","first_page":"238","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.16850000619888306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.05310000106692314,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8992621302604675},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.8481788635253906},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.7140889763832092},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6344780921936035},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5869467258453369},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5182285308837891},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45731258392333984},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.42998021841049194},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3335598409175873},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23880839347839355},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20961371064186096},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1376371681690216},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.06835490465164185}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8992621302604675},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.8481788635253906},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7140889763832092},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6344780921936035},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5869467258453369},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5182285308837891},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45731258392333984},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.42998021841049194},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3335598409175873},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23880839347839355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20961371064186096},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1376371681690216},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.06835490465164185}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000977","descriptor_name":"Antiparasitic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010271","descriptor_name":"Parasites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010271","descriptor_name":"Parasites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010271","descriptor_name":"Parasites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016785","descriptor_name":"Cryptosporidium parvum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016785","descriptor_name":"Cryptosporidium parvum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016785","descriptor_name":"Cryptosporidium parvum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/amiajnl-2013-001700","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2013-001700","pdf_url":"https://academic.oup.com/jamia/article-pdf/21/2/238/17375606/21-2-238.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:23757409","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23757409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:europepmc.org:3306860","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3932453","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2013-001700","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2013-001700","pdf_url":"https://academic.oup.com/jamia/article-pdf/21/2/238/17375606/21-2-238.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G1476642338","display_name":null,"funder_award_id":"R21AI101381","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4263036332","display_name":null,"funder_award_id":"T32-AI055402","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5515774457","display_name":null,"funder_award_id":"P20 GM103496","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6753141453","display_name":null,"funder_award_id":"T32 AI0055402-06","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G736174929","display_name":null,"funder_award_id":"R01 AI072021","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2256225122.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1977173978","https://openalex.org/W1977494225","https://openalex.org/W1977676771","https://openalex.org/W2004935490","https://openalex.org/W2009081245","https://openalex.org/W2010398967","https://openalex.org/W2015810688","https://openalex.org/W2024311391","https://openalex.org/W2028326521","https://openalex.org/W2037788267","https://openalex.org/W2046121774","https://openalex.org/W2062941476","https://openalex.org/W2073761857","https://openalex.org/W2076664894","https://openalex.org/W2080678696","https://openalex.org/W2093313266","https://openalex.org/W2096541451","https://openalex.org/W2112946624","https://openalex.org/W2116536284","https://openalex.org/W2118581189","https://openalex.org/W2121175754","https://openalex.org/W2127553917","https://openalex.org/W2137052779","https://openalex.org/W2137850976","https://openalex.org/W2145321215","https://openalex.org/W2151084213","https://openalex.org/W2152179597","https://openalex.org/W2158217645","https://openalex.org/W2170834744","https://openalex.org/W2171477176","https://openalex.org/W2319538318","https://openalex.org/W2595613062","https://openalex.org/W4242853598"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"identify":[2,72],"potential":[3,56],"opportunities":[4],"for":[5,137,181,203,219],"drug":[6,25,125,182,236],"repurposing":[7],"by":[8,110],"developing":[9],"an":[10],"automated":[11],"approach":[12],"to":[13,54,71,80,112,134,215,233],"pre-screen":[14],"the":[15,46,101,124,138,208],"predicted":[16,102,119],"proteomes":[17],"of":[18,23,39,74,89,118,161,200],"any":[19],"organism":[20],"against":[21],"databases":[22],"known":[24],"targets":[26,60,183],"using":[27,92],"only":[28],"freely":[29],"available":[30],"resources.":[31],"MATERIALS":[32],"AND":[33],"METHODS:":[34],"We":[35],"employed":[36],"a":[37,67,93,217],"combination":[38],"Ruby":[40],"scripts":[41],"that":[42,100,191,207],"leverage":[43],"data":[44],"from":[45,61,66],"DrugBank":[47],"and":[48,52,58,174,196,230],"ChEMBL":[49],"databases,":[50],"MySQL,":[51],"BLAST":[53],"predict":[55,135],"drugs":[57],"their":[59],"13":[62,140],"published":[63],"genomes.":[64],"Results":[65],"previous":[68],"cell-based":[69,94],"screen":[70],"inhibitors":[73,103,120,136],"Cryptosporidium":[75],"parvum":[76,96,205],"growth":[77,97],"were":[78,104],"used":[79,133,214],"validate":[81],"our":[82,201],"in-silico":[83,186],"prediction":[84],"method.":[85],"RESULTS:":[86],"In-vitro":[87,198],"validation":[88,199],"these":[90],"results,":[91],"C":[95,145,204],"assay,":[98],"showed":[99],"significantly":[105],"more":[106,220],"likely":[107],"than":[108],"expected":[109],"chance":[111],"have":[113,184],"confirmed":[114,121],"activity,":[115],"with":[116],"8.9-15.6%":[117],"depending":[122],"on":[123],"target":[126],"database":[127],"used.":[128],"This":[129],"method":[130,209],"was":[131],"then":[132],"following":[139],"disease-causing":[141],"protozoan":[142],"parasites,":[143],"including:":[144],"parvum,":[146],"Entamoeba":[147],"histolytica,":[148],"Giardia":[149],"intestinalis,":[150],"Leishmania":[151,153,155],"braziliensis,":[152],"donovani,":[154],"major,":[156],"Naegleria":[157,162],"gruberi":[158],"(in":[159],"proxy":[160],"fowleri),":[163],"Plasmodium":[164,166],"falciparum,":[165],"vivax,":[167],"Toxoplasma":[168],"gondii,":[169],"Trichomonas":[170],"vaginalis,":[171],"Trypanosoma":[172,175],"brucei":[173],"cruzi.":[176],"CONCLUSIONS:":[177],"Although":[178],"proteome-wide":[179],"screens":[180],"disadvantages,":[185],"methods":[187],"can":[188,212],"be":[189,213],"developed":[190],"are":[192],"fast,":[193],"broad,":[194],"inexpensive,":[195],"effective.":[197],"results":[202],"indicate":[206],"presented":[210],"here":[211],"construct":[216],"library":[218],"directed":[221],"small":[222],"molecule":[223],"screening,":[224],"or":[225],"pipelined":[226],"into":[227],"structural":[228],"modeling":[229],"docking":[231],"programs":[232],"facilitate":[234],"target-based":[235],"development.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}