{"id":"https://openalex.org/W106009065","doi":"https://doi.org/10.1136/amiajnl-2012-001603","title":"Response to 'Use of an algorithm for identifying hidden drug--drug interactions in adverse event reports' by Gooden et al","display_name":"Response to 'Use of an algorithm for identifying hidden drug--drug interactions in adverse event reports' by Gooden et al","publication_year":2013,"publication_date":"2013-01-31","ids":{"openalex":"https://openalex.org/W106009065","doi":"https://doi.org/10.1136/amiajnl-2012-001603","mag":"106009065","pmid":"https://pubmed.ncbi.nlm.nih.gov/23876381"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2012-001603","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001603","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/3/591/6039172/20-3-591.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jamia/article-pdf/20/3/591/6039172/20-3-591.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086753691","display_name":"Nicholas P. Tatonetti","orcid":"https://orcid.org/0000-0002-2700-2597"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. P. Tatonetti","raw_affiliation_strings":["Departments of Biomedical Informatics and Medicine and the Columbia Initiative in Systems Biology, Columbia University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Informatics and Medicine and the Columbia Initiative in Systems Biology, Columbia University, New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070908224","display_name":"Joshua C. Denny","orcid":"https://orcid.org/0000-0002-3049-7332"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Denny","raw_affiliation_strings":["Departments of Biomedical Informatics and Medicine, Vanderbilt University, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biomedical Informatics and Medicine, Vanderbilt University, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084043782","display_name":"Russ B. Altman","orcid":"https://orcid.org/0000-0003-3859-2905"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Altman","raw_affiliation_strings":["Departments of Genetics, Bioengineering, and Medicine, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics, Bioengineering, and Medicine, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00722816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"591","last_page":"591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6525815725326538},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.6306231617927551},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.574135959148407},{"id":"https://openalex.org/keywords/serotonin-reuptake-inhibitor","display_name":"Serotonin reuptake inhibitor","score":0.5544641017913818},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.5163034796714783},{"id":"https://openalex.org/keywords/pravastatin","display_name":"Pravastatin","score":0.5099989175796509},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.4782104194164276},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.47759270668029785},{"id":"https://openalex.org/keywords/paroxetine","display_name":"Paroxetine","score":0.4753838777542114},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4608551859855652},{"id":"https://openalex.org/keywords/medical-record","display_name":"Medical record","score":0.4455323815345764},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.4302127957344055},{"id":"https://openalex.org/keywords/statin","display_name":"Statin","score":0.4171901047229767},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3963964879512787},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3551812171936035},{"id":"https://openalex.org/keywords/cholesterol","display_name":"Cholesterol","score":0.2609332799911499},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2409467101097107},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.1870446503162384},{"id":"https://openalex.org/keywords/antidepressant","display_name":"Antidepressant","score":0.1088733971118927}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6525815725326538},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.6306231617927551},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.574135959148407},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.5544641017913818},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5163034796714783},{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.5099989175796509},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4782104194164276},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.47759270668029785},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.4753838777542114},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4608551859855652},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.4455323815345764},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4302127957344055},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4171901047229767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3963964879512787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3551812171936035},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2609332799911499},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2409467101097107},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1870446503162384},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.1088733971118927},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/amiajnl-2012-001603","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001603","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/3/591/6039172/20-3-591.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:23876381","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23876381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:europepmc.org:2980692","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3628071","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2012-001603","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001603","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/3/591/6039172/20-3-591.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W106009065.pdf"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2105714645","https://openalex.org/W2106618845","https://openalex.org/W2107021160","https://openalex.org/W2117397379","https://openalex.org/W2179854071"],"related_works":["https://openalex.org/W2315394466","https://openalex.org/W2060299957","https://openalex.org/W4302044320","https://openalex.org/W2089781526","https://openalex.org/W2151079680","https://openalex.org/W2178264880","https://openalex.org/W2351228467","https://openalex.org/W4390546975","https://openalex.org/W2041187061","https://openalex.org/W26733326"],"abstract_inverted_index":{"Critical":[0],"evaluation":[1],"of":[2,5,14,30,96],"the":[3,11,18,27,82,94],"results":[4,51],"clinical":[6,28],"studies":[7],"is":[8],"vital":[9],"to":[10,25],"continued":[12],"progress":[13],"medicine.":[15],"We":[16,103],"appreciate":[17],"work":[19],"performed":[20],"by":[21,115,121],"Gooden":[22,84],"and":[23,41,64],"colleagues1":[24],"evaluate":[26],"significance":[29],"a":[31,36,43,53,65,91],"drug":[32],"interaction":[33],"between":[34],"paroxetine,":[35],"selective":[37],"serotonin":[38],"reuptake":[39],"inhibitor,":[40],"pravastatin,":[42],"cholesterol-lowering":[44],"statin,":[45],"that":[46,105],"we":[47],"published":[48],"previously.2":[49],"Our":[50],"demonstrated":[52],"18.5":[54],"mg/dl":[55,67],"increase":[56,68],"in":[57,60,69,93,124],"glucose":[58,70],"levels":[59],"individuals":[61],"without":[62],"diabetes,":[63],"48":[66],"level":[71],"for":[72],"diabetes":[73,99],"patients":[74],"using":[75,100],"three":[76],"electronic":[77],"medical":[78],"record":[79],"systems.":[80],"In":[81],"study,":[83],"et":[85],"al":[86],"1":[87],"did":[88],"not":[89],"find":[90],"difference":[92],"development":[95],"type":[97],"2":[98],"administrative":[101],"data.":[102],"agree":[104],"retrospective":[106],"risk":[107],"estimates":[108],"such":[109,118],"as":[110,119],"ours":[111],"may":[112],"be":[113],"influenced":[114],"selection":[116],"biases,":[117],"confounding":[120],"indication.":[122],"However,":[123],"\u2026":[125]},"counts_by_year":[],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}