{"id":"https://openalex.org/W2097508746","doi":"https://doi.org/10.1136/amiajnl-2012-001525","title":"An information-gain approach to detecting three-way epistatic interactions in genetic association studies","display_name":"An information-gain approach to detecting three-way epistatic interactions in genetic association studies","publication_year":2013,"publication_date":"2013-02-09","ids":{"openalex":"https://openalex.org/W2097508746","doi":"https://doi.org/10.1136/amiajnl-2012-001525","mag":"2097508746","pmid":"https://pubmed.ncbi.nlm.nih.gov/23396514"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2012-001525","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001525","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/4/630/9518115/20-4-630.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jamia/article-pdf/20/4/630/9518115/20-4-630.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101965823","display_name":"Ting Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting Hu","raw_affiliation_strings":["Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA"],"affiliations":[{"raw_affiliation_string":"Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067333778","display_name":"Yuanzhu Chen","orcid":"https://orcid.org/0000-0002-6998-6408"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Yuanzhu Chen","raw_affiliation_strings":["Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","Department of Computer Science, Memorial University, St. John's, Newfoundland, Canada"],"affiliations":[{"raw_affiliation_string":"Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Computer Science, Memorial University, St. John's, Newfoundland, Canada","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070068281","display_name":"Jeff Kiralis","orcid":null},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff W Kiralis","raw_affiliation_strings":["Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA"],"affiliations":[{"raw_affiliation_string":"Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022093098","display_name":"Ryan L. Collins","orcid":"https://orcid.org/0000-0003-1268-9995"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan L Collins","raw_affiliation_strings":["Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA"],"affiliations":[{"raw_affiliation_string":"Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027744572","display_name":"Christian Wejse","orcid":"https://orcid.org/0000-0002-2534-2942"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christian Wejse","raw_affiliation_strings":["Center for Global Health, School of Public Health, Aarhus University, Skejby, Denmark"],"affiliations":[{"raw_affiliation_string":"Center for Global Health, School of Public Health, Aarhus University, Skejby, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028210443","display_name":"Giorgio Sirugo","orcid":"https://orcid.org/0000-0002-0244-6343"},"institutions":[{"id":"https://openalex.org/I4210165969","display_name":"Ospedale San Pietro Fatebenefratelli","ror":"https://ror.org/05fccw142","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165969"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Sirugo","raw_affiliation_strings":["Centro di Genetica, Centro di Ricerca Scientifica, Ospedale San Pietro FBF, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Centro di Genetica, Centro di Ricerca Scientifica, Ospedale San Pietro FBF, Rome, Italy","institution_ids":["https://openalex.org/I4210165969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005123641","display_name":"Scott M. Williams","orcid":"https://orcid.org/0000-0002-4835-9544"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M Williams","raw_affiliation_strings":["Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032971510","display_name":"Jason H. Moore","orcid":"https://orcid.org/0000-0002-5015-1099"},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason H Moore","raw_affiliation_strings":["Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA"],"affiliations":[{"raw_affiliation_string":"Computational Genetics Laboratory, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5032971510"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":{"value":3967,"currency":"USD","value_usd":3967},"fwci":5.3384,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.95795202,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"630","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9842000007629395,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.908976137638092},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.6875041723251343},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5931631326675415},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5273923277854919},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.469451367855072},{"id":"https://openalex.org/keywords/information-gain","display_name":"Information gain","score":0.4133340120315552},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33814477920532227},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.33643728494644165},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3223934769630432},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30683180689811707},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.19504955410957336},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1460990309715271},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.14441415667533875},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1074792742729187}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.908976137638092},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.6875041723251343},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5931631326675415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5273923277854919},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.469451367855072},{"id":"https://openalex.org/C2983203078","wikidata":"https://www.wikidata.org/wiki/Q255166","display_name":"Information gain","level":2,"score":0.4133340120315552},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33814477920532227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33643728494644165},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3223934769630432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30683180689811707},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19504955410957336},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1460990309715271},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.14441415667533875},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1074792742729187},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/amiajnl-2012-001525","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001525","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/4/630/9518115/20-4-630.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:23396514","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23396514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:europepmc.org:2842976","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3721169","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/777f5ec8-dea8-4abc-9c0b-3f22ae0afd80","is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/777f5ec8-dea8-4abc-9c0b-3f22ae0afd80","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hu, T, Chen, Y, Kiralis, J W, Collins, R L, Wejse, C, Sirugo, G, Williams, S M & Moore, J H 2013, 'An information-gain approach to detecting three-way epistatic interactions in genetic association studies', Journal of the American Medical Informatics Association, vol. 20, no. 4. https://doi.org/10.1136/amiajnl-2012-001525","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2012-001525","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001525","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/4/630/9518115/20-4-630.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G205688298","display_name":null,"funder_award_id":"R01-LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3497591915","display_name":null,"funder_award_id":"(NIH)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5614804429","display_name":null,"funder_award_id":"AI59694","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6682602594","display_name":null,"funder_award_id":"LM010098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8919309667","display_name":null,"funder_award_id":"EY022300","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8928357583","display_name":null,"funder_award_id":"R01-AI59694","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097508746.pdf","grobid_xml":"https://content.openalex.org/works/W2097508746.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1479863711","https://openalex.org/W1542772707","https://openalex.org/W1966360257","https://openalex.org/W1967556326","https://openalex.org/W1972629899","https://openalex.org/W1973141736","https://openalex.org/W1989531990","https://openalex.org/W1990139289","https://openalex.org/W2006652270","https://openalex.org/W2007669896","https://openalex.org/W2016138806","https://openalex.org/W2016755304","https://openalex.org/W2030628077","https://openalex.org/W2038486513","https://openalex.org/W2053484352","https://openalex.org/W2056104146","https://openalex.org/W2061680337","https://openalex.org/W2063575312","https://openalex.org/W2064995337","https://openalex.org/W2066669827","https://openalex.org/W2075464412","https://openalex.org/W2076220518","https://openalex.org/W2092946137","https://openalex.org/W2099111195","https://openalex.org/W2100850281","https://openalex.org/W2105058357","https://openalex.org/W2114917617","https://openalex.org/W2118230200","https://openalex.org/W2120670853","https://openalex.org/W2123794412","https://openalex.org/W2124580054","https://openalex.org/W2125858955","https://openalex.org/W2126964466","https://openalex.org/W2130856032","https://openalex.org/W2132914503","https://openalex.org/W2133072544","https://openalex.org/W2133904756","https://openalex.org/W2138020005","https://openalex.org/W2140938728","https://openalex.org/W2151920593","https://openalex.org/W2152905639","https://openalex.org/W2159675211","https://openalex.org/W2478708596","https://openalex.org/W4229670643"],"related_works":["https://openalex.org/W2140249224","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W2802045099","https://openalex.org/W1486217206"],"abstract_inverted_index":{"Our":[0],"study":[1],"provides":[2],"a":[3],"methodological":[4],"basis":[5],"for":[6],"detecting":[7],"and":[8],"characterizing":[9],"high-order":[10],"gene-gene":[11],"interactions":[12],"in":[13],"genetic":[14],"association":[15],"studies.":[16]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}