{"id":"https://openalex.org/W2110366569","doi":"https://doi.org/10.1136/amiajnl-2012-001442","title":"Comparison and validation of genomic predictors for anticancer drug sensitivity","display_name":"Comparison and validation of genomic predictors for anticancer drug sensitivity","publication_year":2013,"publication_date":"2013-01-27","ids":{"openalex":"https://openalex.org/W2110366569","doi":"https://doi.org/10.1136/amiajnl-2012-001442","mag":"2110366569","pmid":"https://pubmed.ncbi.nlm.nih.gov/23355484"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2012-001442","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001442","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/4/597/17374306/20-4-597.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jamia/article-pdf/20/4/597/17374306/20-4-597.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060522543","display_name":"Simon Papillon\u2010Cavanagh","orcid":"https://orcid.org/0000-0002-0372-2266"},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Simon Papillon-Cavanagh","raw_affiliation_strings":["Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010871542","display_name":"Nicolas Jay","orcid":"https://orcid.org/0000-0002-5790-6933"},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicolas De Jay","raw_affiliation_strings":["Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090035556","display_name":"Nehm\u00e9 El-Hachem","orcid":"https://orcid.org/0000-0002-5778-5342"},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nehme Hachem","raw_affiliation_strings":["Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058483070","display_name":"Catharina Olsen","orcid":"https://orcid.org/0000-0002-6193-2296"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Catharina Olsen","raw_affiliation_strings":["Machine Learning Group, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Learning Group, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072869049","display_name":"Gianluca Bontempi","orcid":"https://orcid.org/0000-0001-8621-316X"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Gianluca Bontempi","raw_affiliation_strings":["Machine Learning Group, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Machine Learning Group, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001452511","display_name":"Hugo J.W.L. Aerts","orcid":"https://orcid.org/0000-0002-2122-2003"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugo J W L Aerts","raw_affiliation_strings":["Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA","Department or Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department or Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084245470","display_name":"John Quackenbush","orcid":"https://orcid.org/0000-0002-2702-5879"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Quackenbush","raw_affiliation_strings":["Department or Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department or Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010487226","display_name":"Benjamin Haibe\u2010Kains","orcid":"https://orcid.org/0000-0002-7684-0079"},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Benjamin Haibe-Kains","raw_affiliation_strings":["Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Genomics Laboratory, Institut de recherches cliniques de Montr\u00e9al, University of Montreal, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010487226"],"corresponding_institution_ids":["https://openalex.org/I70931966"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":3.9897,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.94726278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"597","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.32269999384880066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.32269999384880066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.24459999799728394,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.7038367986679077},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.68462735414505},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.6069374084472656},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6065280437469482},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5674135088920593},{"id":"https://openalex.org/keywords/efficacy","display_name":"Efficacy","score":0.5252161622047424},{"id":"https://openalex.org/keywords/drug-trial","display_name":"Drug trial","score":0.46936801075935364},{"id":"https://openalex.org/keywords/anticancer-drug","display_name":"Anticancer drug","score":0.4489419758319855},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.4482465386390686},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4441717863082886},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.42942166328430176},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.40308719873428345},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32777756452560425},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2372942864894867},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1137855052947998},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09802043437957764}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7038367986679077},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.68462735414505},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6069374084472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6065280437469482},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5674135088920593},{"id":"https://openalex.org/C149172746","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Efficacy","level":3,"score":0.5252161622047424},{"id":"https://openalex.org/C2992672634","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Drug trial","level":3,"score":0.46936801075935364},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.4489419758319855},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4482465386390686},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4441717863082886},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.42942166328430176},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40308719873428345},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32777756452560425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2372942864894867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1137855052947998},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09802043437957764},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1136/amiajnl-2012-001442","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001442","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/4/597/17374306/20-4-597.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:23355484","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23355484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/2d5d546b-ce26-4560-8481-05f2ca121293","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/2d5d546b-ce26-4560-8481-05f2ca121293","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Papillon-Cavanagh, S, De Jay, N, El-Hachem, N, Olsen, C, Bontempi, G, Aerts, H J W L, Quackenbush, J & Haibe-Kains, B 2013, 'Comparison and validation of genomic predictors for anticancer drug sensitivity', Journal of the American Medical Informatics Association, vol. 20, no. 4, pp. 597-602. https://doi.org/10.1136/amiajnl-2012-001442","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/145203","is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/145203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Medical Informatics Association, 20 (4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3721163","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3721163","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:148989","is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/comparison-and-validation-of-genomic-predictors-for-anticancer-drug-sensitivity(66a69ada-bef9-4491-8831-0441e97d58ff).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2012-001442","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2012-001442","pdf_url":"https://academic.oup.com/jamia/article-pdf/20/4/597/17374306/20-4-597.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[{"id":"https://openalex.org/G6810244766","display_name":null,"funder_award_id":"R01 LM010129-01","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G7024020200","display_name":null,"funder_award_id":"R01 LM010129","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2110366569.pdf","grobid_xml":"https://content.openalex.org/works/W2110366569.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1963722187","https://openalex.org/W1966701961","https://openalex.org/W1975428912","https://openalex.org/W1982950529","https://openalex.org/W1983854655","https://openalex.org/W1988278380","https://openalex.org/W1989654707","https://openalex.org/W2008345619","https://openalex.org/W2017337590","https://openalex.org/W2018466008","https://openalex.org/W2025396651","https://openalex.org/W2043398720","https://openalex.org/W2053364844","https://openalex.org/W2081222682","https://openalex.org/W2087312216","https://openalex.org/W2090453278","https://openalex.org/W2091336659","https://openalex.org/W2097360283","https://openalex.org/W2113878188","https://openalex.org/W2119479037","https://openalex.org/W2121695897","https://openalex.org/W2122825543","https://openalex.org/W2125440931","https://openalex.org/W2125789330","https://openalex.org/W2128542677","https://openalex.org/W2129296674","https://openalex.org/W2129925362","https://openalex.org/W2131987814","https://openalex.org/W2134257943","https://openalex.org/W2137632714","https://openalex.org/W2145825942","https://openalex.org/W2149453908","https://openalex.org/W2151028167","https://openalex.org/W2151178734","https://openalex.org/W2158275940","https://openalex.org/W2162371443","https://openalex.org/W2168188385","https://openalex.org/W2168715739","https://openalex.org/W2468861811","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1508732282","https://openalex.org/W2159063798","https://openalex.org/W2068142083","https://openalex.org/W2758791195","https://openalex.org/W2999563835","https://openalex.org/W2609331662","https://openalex.org/W2036147078","https://openalex.org/W2353292232","https://openalex.org/W3193181239","https://openalex.org/W3154648057"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"enduring":[2],"challenge":[3],"in":[4,8,23,73,77,125,128,140,165,231,237,255],"personalized":[5,256],"medicine":[6],"lies":[7],"selecting":[9],"the":[10,27,43,51,135,141,157,168,181,206,247],"right":[11],"drug":[12,108],"for":[13,115,177,225,246],"each":[14],"individual":[15],"patient.":[16],"While":[17],"testing":[18],"of":[19,45,53,68,107,118,148,180,199,209],"drugs":[20,46,69,88,162,249],"on":[21,89],"patients":[22],"large":[24,130],"trials":[25],"is":[26],"only":[28],"way":[29],"to":[30,41,66,70,96,100,173,195],"assess":[31],"their":[32,123],"clinical":[33,238],"efficacy":[34],"and":[35,102,127,144,188,235,250],"toxicity,":[36],"we":[37,191],"dramatically":[38],"lack":[39],"resources":[40],"test":[42],"hundreds":[44,67],"currently":[47],"under":[48],"development.":[49],"Therefore":[50],"use":[52],"preclinical":[54],"model":[55],"systems":[56],"has":[57],"been":[58,154],"intensively":[59],"investigated":[60],"as":[61,243],"this":[62],"approach":[63],"enables":[64],"response":[65,194],"be":[71,202,222],"tested":[72,183],"multiple":[74,86],"cell":[75,92,137,149],"lines":[76,138,150],"parallel.":[78],"METHODS:":[79],"Two":[80],"large-scale":[81],"pharmacogenomic":[82],"studies":[83],"recently":[84],"screened":[85],"anticancer":[87],"over":[90],"1000":[91],"lines.":[93],"We":[94,110,121,170],"propose":[95],"combine":[97],"these":[98],"datasets":[99],"build":[101],"robustly":[103,223],"validate":[104,174],"genomic":[105,219],"predictors":[106,117,176,220],"response.":[109],"compared":[111],"five":[112],"different":[113],"approaches":[114],"building":[116],"increasing":[119],"complexity.":[120],"assessed":[122],"performance":[124],"cross-validation":[126],"two":[129],"validation":[131],"sets,":[132],"one":[133],"containing":[134],"same":[136],"present":[139],"training":[142,158],"set":[143],"another":[145],"dataset":[146],"composed":[147],"that":[151,193,218],"have":[152],"never":[153],"used":[155],"during":[156],"phase.":[159],"RESULTS:":[160],"Sixteen":[161],"were":[163,171],"found":[164],"common":[166],"between":[167],"datasets.":[169],"able":[172],"multivariate":[175],"three":[178],"out":[179],"16":[182],"drugs,":[184],"namely":[185],"irinotecan,":[186],"PD-0325901,":[187],"PLX4720.":[189],"Moreover,":[190],"observed":[192],"17-AAG,":[196],"an":[197,252],"inhibitor":[198],"Hsp90,":[200],"could":[201,221,241],"efficiently":[203],"predicted":[204],"by":[205],"expression":[207],"level":[208],"a":[210],"single":[211],"gene,":[212],"NQO1.":[213],"CONCLUSION:":[214],"These":[215],"results":[216],"suggest":[217],"validated":[224,230],"specific":[226],"drugs.":[227],"If":[228],"successfully":[229],"patients'":[232],"tumor":[233],"cells,":[234],"subsequently":[236],"trials,":[239],"they":[240],"act":[242],"companion":[244],"tests":[245],"corresponding":[248],"play":[251],"important":[253],"role":[254],"medicine.":[257]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}