{"id":"https://openalex.org/W2117397379","doi":"https://doi.org/10.1136/amiajnl-2011-000214","title":"A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports","display_name":"A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports","publication_year":2011,"publication_date":"2011-06-15","ids":{"openalex":"https://openalex.org/W2117397379","doi":"https://doi.org/10.1136/amiajnl-2011-000214","mag":"2117397379","pmid":"https://pubmed.ncbi.nlm.nih.gov/21676938"},"language":"en","primary_location":{"id":"doi:10.1136/amiajnl-2011-000214","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2011-000214","pdf_url":"https://academic.oup.com/jamia/article-pdf/19/1/79/17374150/19-1-79.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jamia/article-pdf/19/1/79/17374150/19-1-79.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086753691","display_name":"Nicholas P. Tatonetti","orcid":"https://orcid.org/0000-0002-2700-2597"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas P Tatonetti","raw_affiliation_strings":["Biomedical Informatics Training Program, Stanford University, Stanford, California, USA","Departments of Bioengineering, Genetics, and Medicine, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Training Program, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Departments of Bioengineering, Genetics, and Medicine, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086000118","display_name":"Guy Haskin Fernald","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Haskin Fernald","raw_affiliation_strings":["Biomedical Informatics Training Program, Stanford University, Stanford, California, USA","Departments of Bioengineering, Genetics, and Medicine, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Training Program, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Departments of Bioengineering, Genetics, and Medicine, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084043782","display_name":"Russ B. Altman","orcid":"https://orcid.org/0000-0003-3859-2905"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Russ B Altman","raw_affiliation_strings":["Departments of Bioengineering, Genetics, and Medicine, Stanford University, Stanford, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Bioengineering, Genetics, and Medicine, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084043782"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":3967,"currency":"USD","value_usd":3967},"apc_paid":null,"fwci":6.4976,"has_fulltext":false,"cited_by_count":210,"citation_normalized_percentile":{"value":0.9829222,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"79","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9620000123977661,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9620000123977661,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.6856089234352112},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6683777570724487},{"id":"https://openalex.org/keywords/adverse-drug-event","display_name":"Adverse drug event","score":0.5455824732780457},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5060331225395203},{"id":"https://openalex.org/keywords/adverse-event-reporting-system","display_name":"Adverse Event Reporting System","score":0.48842301964759827},{"id":"https://openalex.org/keywords/drug-reaction","display_name":"Drug reaction","score":0.45625385642051697},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.44844067096710205},{"id":"https://openalex.org/keywords/adverse-drug-reaction","display_name":"Adverse drug reaction","score":0.43835219740867615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42452430725097656},{"id":"https://openalex.org/keywords/event","display_name":"Event (particle physics)","score":0.4177868366241455},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3386245369911194},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.29983285069465637},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2839880585670471}],"concepts":[{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6856089234352112},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6683777570724487},{"id":"https://openalex.org/C3020169349","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug event","level":3,"score":0.5455824732780457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5060331225395203},{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.48842301964759827},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.45625385642051697},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.44844067096710205},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.43835219740867615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42452430725097656},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.4177868366241455},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3386245369911194},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29983285069465637},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2839880585670471},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/amiajnl-2011-000214","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2011-000214","pdf_url":"https://academic.oup.com/jamia/article-pdf/19/1/79/17374150/19-1-79.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},{"id":"pmid:21676938","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21676938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association : JAMIA","raw_type":null},{"id":"pmh:oai:europepmc.org:2529344","is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3240755","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3240755","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3240755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Am Med Inform Assoc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/amiajnl-2011-000214","is_oa":true,"landing_page_url":"https://doi.org/10.1136/amiajnl-2011-000214","pdf_url":"https://academic.oup.com/jamia/article-pdf/19/1/79/17374150/19-1-79.pdf","source":{"id":"https://openalex.org/S129839026","display_name":"Journal of the American Medical Informatics Association","issn_l":"1067-5027","issn":["1067-5027","1527-974X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Informatics Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1325793420","display_name":null,"funder_award_id":"R01 LM005652","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G1914228612","display_name":null,"funder_award_id":"R01 GM102365","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2175121719","display_name":null,"funder_award_id":"LM05652","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G2675325361","display_name":null,"funder_award_id":"R24 GM061374","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4076918073","display_name":null,"funder_award_id":"LM007033","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G4968224489","display_name":null,"funder_award_id":"T15 LM007033","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G5215743085","display_name":null,"funder_award_id":"R24GM61374","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1968682237","https://openalex.org/W2022714644","https://openalex.org/W2026447576","https://openalex.org/W2037599206","https://openalex.org/W2039594635","https://openalex.org/W2047207059","https://openalex.org/W2062941476","https://openalex.org/W2067376669","https://openalex.org/W2074192927","https://openalex.org/W2074289946","https://openalex.org/W2081583413","https://openalex.org/W2083991698","https://openalex.org/W2092661856","https://openalex.org/W2092690624","https://openalex.org/W2098730643","https://openalex.org/W2106618845","https://openalex.org/W2118415328","https://openalex.org/W2124656774","https://openalex.org/W2129796827","https://openalex.org/W2131347449","https://openalex.org/W2151241390","https://openalex.org/W2154896031","https://openalex.org/W2162011385","https://openalex.org/W2170320881","https://openalex.org/W4230604660"],"related_works":["https://openalex.org/W2376885761","https://openalex.org/W2995438986","https://openalex.org/W2398395680","https://openalex.org/W2365386954","https://openalex.org/W2377282230","https://openalex.org/W2348194333","https://openalex.org/W2352744048","https://openalex.org/W2370505849","https://openalex.org/W2520672216","https://openalex.org/W1613393071"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Adverse":[1,98],"drug":[2,18,49,76,165,178,190],"events":[3,108],"(ADEs)":[4],"are":[5,58,65,173],"common":[6],"and":[7,13,17,42,147,181],"account":[8,20],"for":[9,21,54,105,123,176,187,205],"770":[10],"000":[11],"injuries":[12],"deaths":[14],"each":[15],"year":[16],"interactions":[19,63,141,166,179,208],"as":[22,24],"much":[23],"30%":[25],"of":[26,40,62,82,114,125,153,222],"these":[27,106,129,140],"ADEs.":[28],"Spontaneous":[29],"reporting":[30,211],"systems":[31,212],"routinely":[32],"collect":[33],"ADEs":[34],"from":[35],"patients":[36],"on":[37,110],"complex":[38],"combinations":[39],"medications":[41],"provide":[43],"an":[44,203],"opportunity":[45],"to":[46,73,102,117,134,218],"discover":[47],"unexpected":[48],"interactions.":[50,137],"Unfortunately,":[51],"current":[52],"algorithms":[53],"such":[55],"\"signal":[56],"detection\"":[57],"limited":[59],"by":[60,213],"underreporting":[61],"that":[64,127,172],"not":[66],"expected.":[67],"We":[68,87,94,120,138,161],"present":[69],"a":[70,150],"novel":[71,164],"method":[72,201],"identify":[74],"latent":[75],"interaction":[77,191],"signals":[78],"in":[79,132,142,209],"the":[80,96,111,154,183,220],"case":[81],"underreporting.":[83],"MATERIALS":[84],"AND":[85],"METHODS:":[86],"identified":[88,162],"eight":[89,168],"clinically":[90],"significant":[91],"adverse":[92,107,169,224],"events.":[93,225],"used":[95,182],"FDA's":[97],"Event":[99],"Reporting":[100],"System":[101],"build":[103],"profiles":[104,131,217],"based":[109],"side":[112,215],"effects":[113],"drugs":[115,126],"known":[116,177],"produce":[118],"them.":[119],"then":[121],"looked":[122],"pairs":[124],"match":[128],"single-drug":[130],"order":[133],"predict":[135],"potential":[136],"evaluated":[139],"two":[143],"independent":[144],"data":[145],"sets":[146],"also":[148],"through":[149],"retrospective":[151],"analysis":[152],"Stanford":[155],"Hospital":[156],"electronic":[157,184],"medical":[158,185],"records.":[159],"RESULTS:":[160],"171":[163],"(for":[167],"event":[170],"categories)":[171],"significantly":[174],"enriched":[175],"(p=0.0009)":[180],"record":[186],"independently":[188],"testing":[189],"hypotheses":[192],"using":[193,214],"multivariate":[194],"statistical":[195],"models":[196],"with":[197],"covariates.":[198],"CONCLUSION:":[199],"Our":[200],"provides":[202],"option":[204],"detecting":[206],"hidden":[207],"spontaneous":[210],"effect":[216],"infer":[219],"presence":[221],"unreported":[223]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":6}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}
