{"id":"https://openalex.org/W4367042277","doi":"https://doi.org/10.1126/scirobotics.adf1511","title":"Modular reconfiguration of DNA origami assemblies using tile displacement","display_name":"Modular reconfiguration of DNA origami assemblies using tile displacement","publication_year":2023,"publication_date":"2023-04-26","ids":{"openalex":"https://openalex.org/W4367042277","doi":"https://doi.org/10.1126/scirobotics.adf1511","pmid":"https://pubmed.ncbi.nlm.nih.gov/37099635"},"language":"en","primary_location":{"id":"doi:10.1126/scirobotics.adf1511","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scirobotics.adf1511","pdf_url":null,"source":{"id":"https://openalex.org/S4210213233","display_name":"Science Robotics","issn_l":"2470-9476","issn":["2470-9476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Robotics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039433298","display_name":"Namita Sarraf","orcid":"https://orcid.org/0000-0001-8692-7429"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Namita Sarraf","raw_affiliation_strings":["Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027800291","display_name":"Kellen R. Rodriguez","orcid":"https://orcid.org/0000-0001-6453-8131"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kellen R. Rodriguez","raw_affiliation_strings":["Astrophysics, California Institute of Technology, Pasadena, CA 91125, USA","Business Economics and Management, California Institute of Technology, Pasadena, CA 91125, USA","Computer Science, California Institute of Technology, Pasadena, CA 91125, USA"],"affiliations":[{"raw_affiliation_string":"Astrophysics, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":[]},{"raw_affiliation_string":"Business Economics and Management, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":[]},{"raw_affiliation_string":"Computer Science, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016294494","display_name":"Lulu Qian","orcid":"https://orcid.org/0000-0003-4115-2409"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lulu Qian","raw_affiliation_strings":["Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA","Computer Science, California Institute of Technology, Pasadena, CA 91125, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Computer Science, California Institute of Technology, Pasadena, CA 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016294494"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":null,"apc_paid":null,"fwci":4.3821,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.94871795,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"8","issue":"77","first_page":"eadf1511","last_page":"eadf1511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12784","display_name":"Modular Robots and Swarm Intelligence","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.7871280908584595},{"id":"https://openalex.org/keywords/tile","display_name":"Tile","score":0.7740033864974976},{"id":"https://openalex.org/keywords/control-reconfiguration","display_name":"Control reconfiguration","score":0.7732350826263428},{"id":"https://openalex.org/keywords/self-reconfiguring-modular-robot","display_name":"Self-reconfiguring modular robot","score":0.7017847299575806},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4765618145465851},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4710804224014282},{"id":"https://openalex.org/keywords/displacement","display_name":"Displacement (psychology)","score":0.4687538146972656},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4323734939098358},{"id":"https://openalex.org/keywords/adaptability","display_name":"Adaptability","score":0.42645734548568726},{"id":"https://openalex.org/keywords/robot","display_name":"Robot","score":0.4202284812927246},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.27208441495895386},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18446084856987},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.12075787782669067},{"id":"https://openalex.org/keywords/mobile-robot","display_name":"Mobile robot","score":0.11642757058143616},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10741236805915833},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.09476932883262634},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08176615834236145}],"concepts":[{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.7871280908584595},{"id":"https://openalex.org/C2780728851","wikidata":"https://www.wikidata.org/wiki/Q468402","display_name":"Tile","level":2,"score":0.7740033864974976},{"id":"https://openalex.org/C119701452","wikidata":"https://www.wikidata.org/wiki/Q5165881","display_name":"Control reconfiguration","level":2,"score":0.7732350826263428},{"id":"https://openalex.org/C49603950","wikidata":"https://www.wikidata.org/wiki/Q17165512","display_name":"Self-reconfiguring modular robot","level":5,"score":0.7017847299575806},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4765618145465851},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4710804224014282},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.4687538146972656},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4323734939098358},{"id":"https://openalex.org/C177606310","wikidata":"https://www.wikidata.org/wiki/Q5674297","display_name":"Adaptability","level":2,"score":0.42645734548568726},{"id":"https://openalex.org/C90509273","wikidata":"https://www.wikidata.org/wiki/Q11012","display_name":"Robot","level":2,"score":0.4202284812927246},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.27208441495895386},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18446084856987},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12075787782669067},{"id":"https://openalex.org/C19966478","wikidata":"https://www.wikidata.org/wiki/Q4810574","display_name":"Mobile robot","level":3,"score":0.11642757058143616},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10741236805915833},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.09476932883262634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08176615834236145},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C65401140","wikidata":"https://www.wikidata.org/wiki/Q7353385","display_name":"Robot control","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012371","descriptor_name":"Robotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012371","descriptor_name":"Robotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012371","descriptor_name":"Robotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/scirobotics.adf1511","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scirobotics.adf1511","pdf_url":null,"source":{"id":"https://openalex.org/S4210213233","display_name":"Science Robotics","issn_l":"2470-9476","issn":["2470-9476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Robotics","raw_type":"journal-article"},{"id":"pmid:37099635","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37099635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science robotics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1503979119","https://openalex.org/W1583595895","https://openalex.org/W1617520624","https://openalex.org/W1976815031","https://openalex.org/W1980231010","https://openalex.org/W1993933078","https://openalex.org/W2019376824","https://openalex.org/W2032813700","https://openalex.org/W2037209299","https://openalex.org/W2041588219","https://openalex.org/W2060064437","https://openalex.org/W2061764880","https://openalex.org/W2062802768","https://openalex.org/W2064761790","https://openalex.org/W2069436075","https://openalex.org/W2075031385","https://openalex.org/W2078861258","https://openalex.org/W2084011432","https://openalex.org/W2100473511","https://openalex.org/W2126961173","https://openalex.org/W2131610514","https://openalex.org/W2149841830","https://openalex.org/W2158778875","https://openalex.org/W2159104917","https://openalex.org/W2202554670","https://openalex.org/W2298581778","https://openalex.org/W2553366479","https://openalex.org/W2594014878","https://openalex.org/W2635543511","https://openalex.org/W2738534387","https://openalex.org/W2743075877","https://openalex.org/W2756006813","https://openalex.org/W2773368957","https://openalex.org/W2783264152","https://openalex.org/W2784892914","https://openalex.org/W2790708193","https://openalex.org/W2795517941","https://openalex.org/W2810268565","https://openalex.org/W2903161219","https://openalex.org/W2903859101","https://openalex.org/W2924487690","https://openalex.org/W2943829257","https://openalex.org/W3027680984","https://openalex.org/W3028760347","https://openalex.org/W4221089546","https://openalex.org/W4224211317","https://openalex.org/W4283793854","https://openalex.org/W6969095533"],"related_works":["https://openalex.org/W2963148304","https://openalex.org/W2720417647","https://openalex.org/W4386781757","https://openalex.org/W2554741953","https://openalex.org/W4225163935","https://openalex.org/W2064761790","https://openalex.org/W86933508","https://openalex.org/W2765089336","https://openalex.org/W2663455904","https://openalex.org/W2313074614"],"abstract_inverted_index":{"The":[0],"power":[1],"of":[2,9,19,69,74,148,155,161,177,201,227],"natural":[3],"evolution":[4],"lies":[5],"in":[6,85,93,104,112,126],"the":[7,16,80,145,159,175],"adaptability":[8,30],"biological":[10],"organisms":[11],"but":[12,35],"is":[13,56],"constrained":[14],"by":[15,152],"time":[17,48],"scale":[18],"genetics":[20],"and":[21,44,138,166,169,186,243],"reproduction.":[22],"Engineeringartificial":[23],"molecular":[24],"machines":[25,72],"should":[26],"not":[27],"only":[28],"include":[29],"as":[31,224],"a":[32,40,46,66,100,188,202,207,225,234],"core":[33],"feature":[34],"also":[36],"apply":[37],"it":[38],"within":[39],"larger":[41],"design":[42,121,146],"space":[43,147],"at":[45],"faster":[47],"scale.":[49],"A":[50],"lesson":[51],"from":[52],"engineering":[53],"electromechanical":[54],"robots":[55,59],"that":[57,143,229],"modular":[58,91,238],"can":[60],"perform":[61],"diverse":[62],"functions":[63],"through":[64],"self-reconfiguration,":[65],"large-scale":[67],"form":[68,79],"adaptation.":[70],"Molecular":[71],"made":[73],"modular,":[75],"reconfigurable":[76],"components":[77],"may":[78],"basis":[81],"for":[82,123,190,237],"dynamic":[83],"self-reprogramming":[84],"future":[86],"synthetic":[87],"cells.":[88],"To":[89],"achieve":[90],"reconfiguration":[92,239],"DNA":[94],"origami":[95],"assemblies,":[96],"we":[97,119,197],"previously":[98],"developed":[99],"tile":[101,108,111,127,149,213,230,244],"displacement":[102,150,214,231],"mechanism":[103,189,236],"which":[105],"an":[106,113,199],"invader":[107],"replaces":[109],"another":[110],"array":[114],"with":[115,132,164,182,218],"controlled":[116,170],"kinetics.":[117],"Here,":[118],"establish":[120],"principles":[122],"simultaneous":[124],"reconfigurations":[125],"assemblies":[128],"using":[129],"complex":[130],"invaders":[131,163],"distinct":[133],"shapes.":[134],"We":[135,157,173],"present":[136],"toehold":[137],"branch":[139],"migration":[140],"domain":[141],"configurations":[142],"expand":[144],"reactions":[151,215],"two":[153,211],"orders":[154],"magnitude.":[156],"demonstrate":[158],"construction":[160],"multitile":[162],"fixed":[165],"variable":[167,183],"sizes":[168],"size":[171],"distributions.":[172],"investigate":[174],"growth":[176],"three-dimensional":[178],"(3D)":[179],"barrel":[180],"structures":[181],"cross":[184],"sections":[185],"introduce":[187],"reconfiguring":[191],"them":[192],"into":[193,206],"2D":[194],"structures.":[195],"Last,":[196],"show":[198],"example":[200],"sword-shaped":[203],"assembly":[204],"transforming":[205],"snake-shaped":[208],"assembly,":[209],"illustrating":[210],"independent":[212],"occurring":[216],"concurrently":[217],"minimum":[219],"cross-talk.":[220],"This":[221],"work":[222],"serves":[223],"proof":[226],"concept":[228],"could":[232],"be":[233],"fundamental":[235],"robust":[240],"to":[241],"temperature":[242],"concentration.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5}],"updated_date":"2026-03-17T09:09:15.849793","created_date":"2025-10-10T00:00:00"}