{"id":"https://openalex.org/W2008726073","doi":"https://doi.org/10.1117/12.767455","title":"Neurodegenerative changes in Alzheimer's disease: a comparative study of manual, semi-automated, and fully automated assessment using MRI","display_name":"Neurodegenerative changes in Alzheimer's disease: a comparative study of manual, semi-automated, and fully automated assessment using MRI","publication_year":2008,"publication_date":"2008-03-06","ids":{"openalex":"https://openalex.org/W2008726073","doi":"https://doi.org/10.1117/12.767455","mag":"2008726073"},"language":"en","primary_location":{"id":"doi:10.1117/12.767455","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.767455","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108362725","display_name":"Klaus Fritzsche","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Klaus H. Fritzsche","raw_affiliation_strings":["German Cancer Research Ctr. (Germany)"],"affiliations":[{"raw_affiliation_string":"German Cancer Research Ctr. (Germany)","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108765941","display_name":"Frederik L. Giesel","orcid":"https://orcid.org/0000-0002-9669-5593"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frederik L. Giesel","raw_affiliation_strings":["German Cancer Research Ctr. (Germany)"],"affiliations":[{"raw_affiliation_string":"German Cancer Research Ctr. (Germany)","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109501628","display_name":"Tobias Heimann","orcid":"https://orcid.org/0009-0002-8496-5100"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Heimann","raw_affiliation_strings":["German Cancer Research Ctr. (Germany)"],"affiliations":[{"raw_affiliation_string":"German Cancer Research Ctr. (Germany)","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046714439","display_name":"Philipp A. Thomann","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp A. Thomann","raw_affiliation_strings":["Univ. of Heidelberg (Germany)","University of Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Univ. of Heidelberg (Germany)","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047104707","display_name":"Horst K. Hahn","orcid":"https://orcid.org/0000-0001-7512-5762"},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Horst K. Hahn","raw_affiliation_strings":["MeVis Research (Germany)"],"affiliations":[{"raw_affiliation_string":"MeVis Research (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027835558","display_name":"Johannes Pantel","orcid":null},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Pantel","raw_affiliation_strings":["Univ. of Frankfurt (Germany)","University of Frankfurt (Germany)"],"affiliations":[{"raw_affiliation_string":"Univ. of Frankfurt (Germany)","institution_ids":[]},{"raw_affiliation_string":"University of Frankfurt (Germany)","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110087559","display_name":"Johannes Schr\u00f6der","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Schr\u00f6der","raw_affiliation_strings":["Univ. of Heidelberg (Germany)","University of Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Univ. of Heidelberg (Germany)","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081133327","display_name":"Marco Essig","orcid":"https://orcid.org/0000-0002-7964-2297"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marco Essig","raw_affiliation_strings":["German Cancer Research Ctr. (Germany)"],"affiliations":[{"raw_affiliation_string":"German Cancer Research Ctr. (Germany)","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109185878","display_name":"Hans-Peter Meinzer","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Meinzer","raw_affiliation_strings":["German Cancer Research Ctr. (Germany)"],"affiliations":[{"raw_affiliation_string":"German Cancer Research Ctr. (Germany)","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5108362725"],"corresponding_institution_ids":["https://openalex.org/I17937529"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.10300339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"6915","issue":null,"first_page":"69151V","last_page":"69151V"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/automated-method","display_name":"Automated method","score":0.5767384767532349},{"id":"https://openalex.org/keywords/reproducibility","display_name":"Reproducibility","score":0.5657219290733337},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4959460198879242},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"Neurodegeneration","score":0.47487872838974},{"id":"https://openalex.org/keywords/neuropsychological-assessment","display_name":"Neuropsychological assessment","score":0.46359342336654663},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.446475625038147},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.4209410548210144},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4173721373081207},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4047700762748718},{"id":"https://openalex.org/keywords/neuropsychology","display_name":"Neuropsychology","score":0.38051411509513855},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3540138006210327},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3296251893043518},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.3036864399909973},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3023339807987213},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.0837143063545227}],"concepts":[{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.5767384767532349},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5657219290733337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4959460198879242},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.47487872838974},{"id":"https://openalex.org/C536788834","wikidata":"https://www.wikidata.org/wiki/Q7002588","display_name":"Neuropsychological assessment","level":4,"score":0.46359342336654663},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.446475625038147},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4209410548210144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4173721373081207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4047700762748718},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.38051411509513855},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3540138006210327},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3296251893043518},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3036864399909973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3023339807987213},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0837143063545227},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.767455","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.767455","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:fraunhofer.de:N-173306","is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/N-173306.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer MEVIS","raw_type":"Conference Paper"},{"id":"pmh:oai:publica.fraunhofer.de:publica/361543","is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/361543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5799999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1603769546","https://openalex.org/W1840930882","https://openalex.org/W1841365689","https://openalex.org/W1966865971","https://openalex.org/W1970488531","https://openalex.org/W1971316923","https://openalex.org/W1972978214","https://openalex.org/W1983673952","https://openalex.org/W2010280952","https://openalex.org/W2017865966","https://openalex.org/W2019161608","https://openalex.org/W2032980536","https://openalex.org/W2036162736","https://openalex.org/W2046121601","https://openalex.org/W2054092091","https://openalex.org/W2058608956","https://openalex.org/W2063136428","https://openalex.org/W2097895364","https://openalex.org/W2105189592","https://openalex.org/W2122164674","https://openalex.org/W2122632052","https://openalex.org/W2122888777","https://openalex.org/W2125993125","https://openalex.org/W2143584322","https://openalex.org/W2143895814","https://openalex.org/W2149142893","https://openalex.org/W2156220037","https://openalex.org/W2158514158","https://openalex.org/W2169406722","https://openalex.org/W2610828489"],"related_works":["https://openalex.org/W2413717610","https://openalex.org/W1973270181","https://openalex.org/W2417696084","https://openalex.org/W2368782778","https://openalex.org/W2087830269","https://openalex.org/W3106281778","https://openalex.org/W638612878","https://openalex.org/W4324138256","https://openalex.org/W2083330954","https://openalex.org/W2980485735"],"abstract_inverted_index":{"Objective":[0],"quantification":[1],"of":[2,30,37,97,103,119,127,137,167],"disease":[3,48],"specific":[4],"neurodegenerative":[5],"changes":[6,45,90],"can":[7],"facilitate":[8],"diagnosis":[9],"and":[10,18,50,66,79,123,150,159,190,204,214],"therapeutic":[11],"monitoring":[12],"in":[13,26,46,142],"several":[14],"neuropsychiatric":[15],"disorders.":[16],"Reproducibility":[17],"easy-to-perform":[19],"assessment":[20],"are":[21],"essential":[22],"to":[23,139,174],"ensure":[24],"applicability":[25],"clinical":[27,87,218],"environments.":[28],"Aim":[29],"this":[31],"comparative":[32],"study":[33],"is":[34,132],"the":[35,104,120,143,182,206],"evaluation":[36],"a":[38,84,95,116,124,161],"fully":[39],"automated":[40,177,192],"approach":[41,178],"that":[42],"assesses":[43],"atrophic":[44],"Alzheimer's":[47],"(AD)":[49],"Mild":[51],"Cognitive":[52],"Impairment":[53],"(MCI).":[54],"21":[55,61],"healthy":[56],"volunteers":[57],"(mean":[58],"age":[59],"66.2),":[60],"patients":[62,68,152],"with":[63,69,112,171,181],"MCI":[64,172],"(66.6),":[65],"10":[67],"AD":[70,151],"(65.1)":[71],"were":[72,91,110],"enrolled.":[73],"Subjects":[74],"underwent":[75],"extensive":[76],"neuropsychological":[77],"testing":[78],"MRI":[80],"was":[81],"conducted":[82],"on":[83],"1.5":[85],"Tesla":[86],"scanner.":[88],"Atrophic":[89],"measured":[92],"automatically":[93],"by":[94],"series":[96],"image":[98],"processing":[99],"steps":[100],"including":[101],"state":[102],"art":[105],"brain":[106],"mapping":[107],"techniques.":[108],"Results":[109],"compared":[111,173],"two":[113,138],"reference":[114],"approaches:":[115],"manual":[117,183],"segmentation":[118],"hippocampal":[121],"formation":[122],"semi-automated":[125],"estimation":[126],"temporal":[128],"horn":[129],"volume,":[130],"which":[131],"based":[133],"upon":[134],"interactive":[135],"selection":[136],"six":[140],"landmarks":[141],"ventricular":[144],"system.":[145],"All":[146],"approaches":[147],"separated":[148],"controls":[149],"significantly":[153,180],"(10<sup>-5</sup>":[154],"<":[155,157,188,197],"p":[156,196],"10<sup>-4</sup>)":[158],"showed":[160],"slight":[162],"but":[163],"not":[164],"significant":[165],"increase":[166],"neurodegeneration":[168],"for":[169,217],"subjects":[170],"volunteers.":[175],"The":[176],"correlated":[179],"(<i>r</i>":[184,193],"=":[185,194],"-0.65,":[186],"<i>p</i>":[187],"10<sup>-6</sup>)":[189],"semi":[191],"-0.83,":[195],"10<sup>-13</sup>)":[198],"measurements.":[199],"It":[200],"proved":[201],"high":[202],"accuracy":[203],"at":[205],"same":[207],"time":[208,212],"maximized":[209],"observer":[210],"independency,":[211],"reduction":[213],"thus":[215],"usefulness":[216],"routine.":[219]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
