{"id":"https://openalex.org/W2922075503","doi":"https://doi.org/10.1117/12.2513588","title":"Quantitative imaging analysis to guide biopsy for molecular biomarkers","display_name":"Quantitative imaging analysis to guide biopsy for molecular biomarkers","publication_year":2019,"publication_date":"2019-03-08","ids":{"openalex":"https://openalex.org/W2922075503","doi":"https://doi.org/10.1117/12.2513588","mag":"2922075503"},"language":"en","primary_location":{"id":"doi:10.1117/12.2513588","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2513588","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055371538","display_name":"Derek J. Doss","orcid":"https://orcid.org/0000-0002-2685-0762"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Derek J. Doss","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036452971","display_name":"Jon S. Heiselman","orcid":"https://orcid.org/0000-0002-4414-8846"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon S. Heiselman","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101911425","display_name":"Ma Luo","orcid":"https://orcid.org/0000-0003-4581-3454"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ma Luo","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069241079","display_name":"Logan W. Clements","orcid":"https://orcid.org/0000-0001-7907-1992"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan W. Clements","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036352350","display_name":"Michael I. Miga","orcid":"https://orcid.org/0000-0002-0694-9765"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael I. Miga","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018663815","display_name":"Daniel B. Brown","orcid":"https://orcid.org/0000-0003-0533-2883"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Brown","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023487474","display_name":"Filip Banovac","orcid":"https://orcid.org/0000-0001-5186-4333"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filip Banovac","raw_affiliation_strings":["Vanderbilt Institute for Surgery and Engineering (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Institute for Surgery and Engineering (United States)","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5055371538"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0303752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"105","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4924803674221039}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4924803674221039}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2513588","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2513588","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1038682962","https://openalex.org/W1968048579","https://openalex.org/W2032284698","https://openalex.org/W2034432063","https://openalex.org/W2048999265","https://openalex.org/W2067256262","https://openalex.org/W2114546946","https://openalex.org/W2142568997","https://openalex.org/W2150575159","https://openalex.org/W2803358834"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"Although":[0],"resection":[1],"and":[2,88,144,162,241,252,282],"transplantation":[3],"are":[4,15,35,40,54,61],"primary":[5],"curative":[6],"methods":[7,23],"of":[8,44,91,104,119,142,169,187,202,212,236,275],"treatment":[9,22,45,111,164],"for":[10,116,132,139,173,219],"hepatocellular":[11],"carcinoma,":[12],"many":[13,140],"patients":[14,156],"not":[16,69,129,137],"candidates.":[17],"In":[18,151],"these":[19,38,170],"cases,":[20],"other":[21],"such":[24],"as":[25],"selective":[26],"internal":[27],"radiation":[28,34],"therapy,":[29],"chemotherapy,":[30],"or":[31],"external":[32],"beam":[33],"used.":[36],"While":[37,68,121],"treatments":[39],"effective,":[41],"patient-specific":[42],"customization":[43],"could":[46,72,85],"be":[47,146,245,269],"beneficial.":[48],"Recent":[49],"advances":[50],"in":[51,250],"personalized":[52],"medicine":[53],"making":[55],"this":[56,125,152],"possible,":[57],"but":[58],"often":[59],"there":[60],"multiple":[62],"phenotypes":[63],"within":[64],"a":[65,74,98,194],"proliferating":[66],"tumor.":[67],"standard,":[70],"one":[71,84],"envision":[73],"serial":[75],"longitudinal":[76,117],"biopsy":[77,115],"approach":[78],"with":[79,157],"more":[80],"phenotypically-targeted":[81],"therapeutics":[82],"if":[83],"detect":[86],"responding":[87],"non-responding":[89],"regions":[90,103],"tumor":[92,106,276,280],"over":[93],"time.":[94],"This":[95],"work":[96],"proposes":[97],"method":[99],"to":[100,110,112,230,244,268],"determine":[101],"active":[102],"the":[105,177,203,210,213,234,237,260,278],"that":[107],"differentially":[108],"respond":[109],"better":[113],"guide":[114],"personalization":[118],"treatment.":[120],"PET":[122],"may":[123],"serve":[124],"purpose,":[126],"it":[127],"is":[128,136],"easily":[130],"used":[131,218,229],"real-time":[133],"image":[134],"guidance,":[135],"effective":[138],"types":[141],"tumors,":[143],"can":[145],"confounded":[147],"by":[148,193,199],"inflammatory":[149],"responses.":[150],"work,":[153],"ten":[154],"total":[155,178],"imaging":[158],"sequences":[159],"from":[160],"before":[161],"after":[163],"were":[165,171,217,255,284],"retrospectively":[166],"obtained.":[167],"Five":[168],"selected":[172],"analysis":[174],"based":[175],"on":[176],"liver":[179],"volume":[180],"change.":[181],"A":[182],"two-phase":[183],"alignment":[184],"process":[185,197],"comprised":[186],"an":[188],"intensity-based":[189],"rigid":[190],"registration":[191],"followed":[192],"nonrigid":[195],"refining":[196],"driven":[198],"bulk":[200],"deformation":[201],"organ":[204],"surface":[205,226],"was":[206,228,242,266],"performed.":[207],"To":[208,271],"assess":[209,272],"accuracy":[211],"registration,":[214,259],"two":[215],"metrics":[216],"preliminary":[220],"results.":[221],"The":[222],"mean":[223,261],"closest":[224],"point":[225],"distance":[227,263],"quantify":[231],"how":[232],"well":[233],"surfaces":[235],"registered":[238,279],"livers":[239],"match":[240],"found":[243,267],"2.65±3.54mm.":[246],"Anatomical":[247],"features":[248,265],"visible":[249],"pre-":[251,281],"post-treatment":[253,283],"images":[254],"also":[256],"identified.":[257],"After":[258],"Euclidean":[262],"between":[264],"5.22±4.06mm.":[270],"potential":[273],"areas":[274],"change,":[277],"overlaid.":[285]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}