{"id":"https://openalex.org/W2791813230","doi":"https://doi.org/10.1117/12.2283231","title":"Altered structural-functional coupling of large-scale brain networks in early Tourette syndrome children","display_name":"Altered structural-functional coupling of large-scale brain networks in early Tourette syndrome children","publication_year":2018,"publication_date":"2018-03-12","ids":{"openalex":"https://openalex.org/W2791813230","doi":"https://doi.org/10.1117/12.2283231","mag":"2791813230"},"language":"en","primary_location":{"id":"doi:10.1117/12.2283231","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2283231","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100669549","display_name":"Huiguang He","orcid":"https://orcid.org/0000-0002-0684-1711"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]},{"id":"https://openalex.org/I4210097554","display_name":"Center for Excellence in Brain Science and Intelligence Technology","ror":"https://ror.org/00vpwhm04","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210097554"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiguang He","raw_affiliation_strings":["Ctr. for Excellence in Brain Science and Intelligence Technology (China)","Institute of Automation (China)","Univ. of Chinese Academy of Sciences (China)"],"affiliations":[{"raw_affiliation_string":"Ctr. for Excellence in Brain Science and Intelligence Technology (China)","institution_ids":["https://openalex.org/I4210097554"]},{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"Univ. of Chinese Academy of Sciences (China)","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025525079","display_name":"Hongwei Wen","orcid":"https://orcid.org/0000-0003-1717-7235"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]},{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Wen","raw_affiliation_strings":["Institute of Automation (China)","Southwest Univ. (China)","Univ. of Chinese Academy of Sciences (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"Southwest Univ. (China)","institution_ids":["https://openalex.org/I142108993"]},{"raw_affiliation_string":"Univ. of Chinese Academy of Sciences (China)","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320085","display_name":"Yue Liu","orcid":"https://orcid.org/0000-0002-6784-8802"},"institutions":[{"id":"https://openalex.org/I4210144404","display_name":"Beijing Children\u2019s Hospital","ror":"https://ror.org/04skmn292","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144404"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Liu","raw_affiliation_strings":["Beijing Children's Hospital, Capital Medical Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Beijing Children's Hospital, Capital Medical Univ. (China)","institution_ids":["https://openalex.org/I4210144404","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035313775","display_name":"Yun Peng","orcid":"https://orcid.org/0000-0001-8213-9716"},"institutions":[{"id":"https://openalex.org/I4210144404","display_name":"Beijing Children\u2019s Hospital","ror":"https://ror.org/04skmn292","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144404"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Peng","raw_affiliation_strings":["Beijing Children's Hospital, Capital Medical Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Beijing Children's Hospital, Capital Medical Univ. (China)","institution_ids":["https://openalex.org/I4210144404","https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059649600","display_name":"Jishui Zhang","orcid":"https://orcid.org/0000-0002-5573-7988"},"institutions":[{"id":"https://openalex.org/I4210144404","display_name":"Beijing Children\u2019s Hospital","ror":"https://ror.org/04skmn292","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144404"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jishui Zhang","raw_affiliation_strings":["Beijing Children's Hospital, Capital Medical Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Beijing Children's Hospital, Capital Medical Univ. (China)","institution_ids":["https://openalex.org/I4210144404","https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100669549"],"corresponding_institution_ids":["https://openalex.org/I4210094879","https://openalex.org/I4210097554","https://openalex.org/I4210165038"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02661918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":null,"first_page":"79","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6403663754463196},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.5697900056838989},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.5567752122879028},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.548710823059082},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5446980595588684},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.49988269805908203},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"Pathophysiology","score":0.46721068024635315},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.41302645206451416},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3444432020187378},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1679263412952423},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.07304611802101135}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6403663754463196},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.5697900056838989},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.5567752122879028},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.548710823059082},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5446980595588684},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.49988269805908203},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.46721068024635315},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41302645206451416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3444432020187378},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1679263412952423},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07304611802101135}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2283231","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2283231","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},{"id":"pmh:oai:ir.psych.ac.cn:311026/27749","is_oa":false,"landing_page_url":"http://ir.psych.ac.cn/handle/311026/27749","pdf_url":null,"source":{"id":"https://openalex.org/S4377196583","display_name":"Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210131870","host_organization_name":"Institute of Psychology, Chinese Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210131870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u4f1a\u8bae\u8bba\u6587"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1586771686","https://openalex.org/W1970375293","https://openalex.org/W2006312249","https://openalex.org/W2028645759","https://openalex.org/W2045694199","https://openalex.org/W2051033225","https://openalex.org/W2065634845","https://openalex.org/W2078152479","https://openalex.org/W2081841619","https://openalex.org/W2088158949","https://openalex.org/W2099783393","https://openalex.org/W2106396500","https://openalex.org/W2119132502","https://openalex.org/W2152556184","https://openalex.org/W2162615325","https://openalex.org/W2292869756","https://openalex.org/W2521738011","https://openalex.org/W2539170191","https://openalex.org/W2561231623","https://openalex.org/W2597287996","https://openalex.org/W2611951306","https://openalex.org/W2619316636","https://openalex.org/W2751794848","https://openalex.org/W4240271001","https://openalex.org/W4249244655","https://openalex.org/W6635192493","https://openalex.org/W6651942685","https://openalex.org/W6672171336","https://openalex.org/W6683971827","https://openalex.org/W6734863643","https://openalex.org/W6737492395"],"related_works":["https://openalex.org/W2143570064","https://openalex.org/W2075991736","https://openalex.org/W3205149984","https://openalex.org/W2038307665","https://openalex.org/W2948361065","https://openalex.org/W2793605638","https://openalex.org/W1520477417","https://openalex.org/W1585336261","https://openalex.org/W3150454329","https://openalex.org/W4250679599"],"abstract_inverted_index":{"Tourette":[0],"syndrome":[1],"(TS)":[2],"is":[3],"a":[4],"childhood-onset":[5],"neurobehavioral":[6],"disorder":[7],"and":[8,31,38,62,69,78,104,113,127,147,154,182,189,204,215],"its":[9],"pathophysiological":[10],"mechanism":[11],"remains":[12],"elusive.":[13],"At":[14],"present,":[15],"TS-related":[16],"abnormalities":[17,42],"in":[18,43,132,140,194,213],"either":[19],"structural":[20,68],"connectivity":[21,25],"(SC)":[22],"or":[23],"functional":[24,70,94,119,148,168],"(FC)":[26],"have":[27],"extensively":[28],"been":[29],"described,":[30],"discrepancies":[32],"were":[33,85,106,130],"apparent":[34],"between":[35,99],"the":[36,44,89,100,122,145,176,180,217,231],"SC":[37,103,178],"FC":[39,64,91,105,138],"studies.":[40],"However,":[41],"SC-FC":[45,109,159,206],"correlation":[46,98],"for":[47,73,219,224],"early":[48],"TS":[49,76,141,164,195,225],"children":[50,77],"remain":[51],"poorly":[52],"understood.":[53],"In":[54],"our":[55,198],"study,":[56],"we":[57,135],"used":[58],"probabilistic":[59],"diffusion":[60],"tractography":[61],"resting-state":[63],"to":[65,87,167,175],"construct":[66],"large-scale":[67],"brain":[71,181,192,211],"networks":[72,92],"34":[74],"drug-naive":[75],"42":[79],"healthy":[80],"children.":[81,196],"Graph":[82],"theoretical":[83],"approaches":[84],"employed":[86],"divide":[88],"group-averaged":[90],"into":[93],"modules.":[95,156],"The":[96,157],"Pearson":[97],"entries":[101],"of":[102,179,186,234],"estimated":[107],"as":[108,227,229],"coupling":[110,139,160],"within":[111,152],"whole-brain":[112,146,203],"each":[114],"module.":[115],"Although":[116],"five":[117],"common":[118],"modules":[120],"(including":[121],"sensorimotor,":[123],"default-mode,":[124],"fronto-parietal,":[125],"temporo-occipital":[126],"subcortical":[128,155],"modules)":[129],"identified":[131],"both":[133],"groups,":[134],"found":[136],"SC\u2013":[137],"exhibited":[142],"increased":[143,158],"at":[144],"modular":[149],"level,":[150],"especially":[151],"sensorimotor":[153],"may":[161,183,208],"suggest":[162],"that":[163,170,201],"pathology":[165],"leads":[166],"interactions":[169],"are":[171],"more":[172,187],"directly":[173],"related":[174],"underlying":[177],"be":[184],"indicative":[185],"stringent":[188],"less":[190],"dynamic":[191],"function":[193,212],"Together,":[197],"study":[199],"demonstrated":[200],"altered":[202],"module-dependent":[205],"couplings":[207],"underlie":[209],"abnormal":[210],"TS,":[214],"highlighted":[216],"potential":[218],"using":[220],"multimodal":[221],"neuroimaging":[222],"biomarkers":[223],"diagnosis":[226],"well":[228],"understanding":[230],"pathophysiologic":[232],"mechanisms":[233],"TS.":[235]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2018-03-29T00:00:00"}