{"id":"https://openalex.org/W2594951141","doi":"https://doi.org/10.1117/12.2254705","title":"Direct biomechanical modeling of trabecular bone using a nonlinear manifold-based volumetric representation","display_name":"Direct biomechanical modeling of trabecular bone using a nonlinear manifold-based volumetric representation","publication_year":2017,"publication_date":"2017-03-13","ids":{"openalex":"https://openalex.org/W2594951141","doi":"https://doi.org/10.1117/12.2254705","mag":"2594951141"},"language":"en","primary_location":{"id":"doi:10.1117/12.2254705","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254705","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027768127","display_name":"Dakai Jin","orcid":"https://orcid.org/0000-0002-4806-2943"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dakai Jin","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015580213","display_name":"Jia Lu","orcid":"https://orcid.org/0000-0001-5753-5362"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Lu","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018595476","display_name":"Xiaoliu Zhang","orcid":"https://orcid.org/0000-0002-2085-3997"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoliu Zhang","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559654","display_name":"Cheng Chen","orcid":"https://orcid.org/0000-0001-9017-9195"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Chen","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011715120","display_name":"Er\u2010Wei Bai","orcid":"https://orcid.org/0000-0003-0750-436X"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ErWei Bai","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033203259","display_name":"Punam K. Saha","orcid":"https://orcid.org/0000-0003-1576-118X"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Punam K. Saha","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027768127"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03106476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10137","issue":null,"first_page":"101371U","last_page":"101371U"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"Trabecular bone","score":0.8273789882659912},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.623549222946167},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5075503587722778},{"id":"https://openalex.org/keywords/biomechanics","display_name":"Biomechanics","score":0.4756317138671875},{"id":"https://openalex.org/keywords/manifold","display_name":"Manifold (fluid mechanics)","score":0.4582667946815491},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.45466676354408264},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.2326841950416565},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15336346626281738},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.1517927348613739},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15056446194648743},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09122097492218018}],"concepts":[{"id":"https://openalex.org/C3018268312","wikidata":"https://www.wikidata.org/wiki/Q2671642","display_name":"Trabecular bone","level":3,"score":0.8273789882659912},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.623549222946167},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5075503587722778},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.4756317138671875},{"id":"https://openalex.org/C529865628","wikidata":"https://www.wikidata.org/wiki/Q1790740","display_name":"Manifold (fluid mechanics)","level":2,"score":0.4582667946815491},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.45466676354408264},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2326841950416565},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15336346626281738},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.1517927348613739},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15056446194648743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09122097492218018},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2254705","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254705","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W129495808","https://openalex.org/W1965930865","https://openalex.org/W1970215274","https://openalex.org/W1970550825","https://openalex.org/W1988316565","https://openalex.org/W1993457878","https://openalex.org/W2000425991","https://openalex.org/W2009399798","https://openalex.org/W2028065902","https://openalex.org/W2034499005","https://openalex.org/W2035180720","https://openalex.org/W2040156285","https://openalex.org/W2043362084","https://openalex.org/W2048250502","https://openalex.org/W2050592024","https://openalex.org/W2051391248","https://openalex.org/W2054689187","https://openalex.org/W2057419293","https://openalex.org/W2064281076","https://openalex.org/W2065237075","https://openalex.org/W2066056548","https://openalex.org/W2066749771","https://openalex.org/W2068934234","https://openalex.org/W2070914367","https://openalex.org/W2074747564","https://openalex.org/W2077498288","https://openalex.org/W2085086344","https://openalex.org/W2087378917","https://openalex.org/W2102024055","https://openalex.org/W2106629079","https://openalex.org/W2106990937","https://openalex.org/W2111064390","https://openalex.org/W2113697838","https://openalex.org/W2122017330","https://openalex.org/W2123897227","https://openalex.org/W2138997396","https://openalex.org/W2159591750","https://openalex.org/W2256257390","https://openalex.org/W2293454490","https://openalex.org/W2317711251","https://openalex.org/W2424606423","https://openalex.org/W4205649593","https://openalex.org/W4206679801","https://openalex.org/W4229750588","https://openalex.org/W6605235941","https://openalex.org/W6696727376","https://openalex.org/W6717614431"],"related_works":["https://openalex.org/W3014307317","https://openalex.org/W2668228314","https://openalex.org/W1537355970","https://openalex.org/W581996473","https://openalex.org/W2183559900","https://openalex.org/W2722458086","https://openalex.org/W6628501","https://openalex.org/W1543792462","https://openalex.org/W4256287444","https://openalex.org/W2127019682"],"abstract_inverted_index":{"Osteoporosis":[0],"is":[1,24,71,74,118,171],"associated":[2],"with":[3,99,250],"increased":[4],"fracture":[5,33,51],"risk.":[6,34,52],"Recent":[7],"advancement":[8],"in":[9,76,124],"the":[10,100,125,135,151,162,174,185,212,221,237,251,261,276,284,287,297],"area":[11],"of":[12,18,29,39,47,68,89,104,143,184,192,244,286,299,311],"<i>in":[13],"vivo</i>":[14],"imaging":[15,191],"allows":[16],"segmentation":[17,103],"trabecular":[19,69],"bone":[20,30,48],"(TB)":[21],"microstructures,":[22],"which":[23],"a":[25,43,56,84,105,121,154,165,241,300,307,312],"known":[26],"key":[27],"determinant":[28],"strength":[31,49],"and":[32,50,108,112,132,140,216,247,295],"An":[35,115],"accurate":[36],"biomechanical":[37,60,168],"modelling":[38,61,291],"TB":[40,59,90,106,157,176,208,238],"micro-architecture":[41],"provides":[42],"comprehensive":[44],"summary":[45],"measure":[46],"In":[53,161],"this":[54],"paper,":[55],"new":[57,213,288,301],"direct":[58,166,233,302],"method":[62,152,186],"using":[63,189,211,232,254],"nonlinear":[64,85,289,308],"manifold-based":[65,86],"volumetric":[66,87],"reconstruction":[67],"network":[70],"presented.":[72],"It":[73],"accomplished":[75],"two":[77,277],"sequential":[78],"modules.":[79],"The":[80,182],"first":[81],"module":[82],"reconstructs":[83],"representation":[88],"networks":[91],"from":[92,220],"three-dimensional":[93],"digital":[94,102],"images.":[95],"Specifically,":[96],"it":[97],"starts":[98],"fuzzy":[101],"network,":[107],"computes":[109],"its":[110,248],"surface":[111],"curve":[113,126],"skeletons.":[114],"individual":[116,144],"trabecula":[117],"identified":[119],"as":[120],"topological":[122],"segment":[123],"skeleton.":[127],"Using":[128],"geometric":[129],"analysis,":[130],"smoothing":[131],"optimization":[133],"techniques,":[134],"algorithm":[136,215,292],"generates":[137,153],"smooth,":[138],"curved,":[139],"continuous":[141],"representations":[142],"trabeculae":[145],"glued":[146],"at":[147,159],"their":[148],"junctions.":[149,160],"Also,":[150],"geometrically":[155],"consistent":[156],"volume":[158,177,209,243],"second":[163],"module,":[164],"computational":[167],"stress-strain":[169],"analysis":[170,235,259,305],"applied":[172],"on":[173,236,306],"reconstructed":[175],"to":[178],"predict":[179],"mechanical":[180,234,303],"measures.":[181,279],"accuracy":[183,285],"was":[187,225,230,264,273],"examined":[188],"micro-CT":[190,223,255],"cadaveric":[193],"distal":[194],"tibia":[195],"specimens":[196],"(N":[197],"=":[198,205,271],"12).":[199],"A":[200,266],"high":[201],"linear":[202,268],"correlation":[203,249,269],"(r":[204,270],"0.95)":[206],"between":[207,275],"computed":[210,231,253],"manifold-modelling":[214],"that":[217],"directly":[218],"derived":[219],"voxel-based":[222],"images":[224],"observed.":[226],"Young\u2019s":[227],"modulus":[228],"(YM)":[229],"manifold-model":[239],"over":[240,260],"cubical":[242],"interest":[245],"(VOI),":[246],"YM,":[252],"based":[256],"conventional":[257],"finite-element":[258],"same":[262],"VOI,":[263],"examined.":[265],"moderate":[267],"0.77)":[272],"observed":[274],"YM":[278],"This":[280],"preliminary":[281],"results":[282],"show":[283],"manifold":[290,309],"for":[293],"TB,":[294],"demonstrate":[296],"feasibility":[298],"strain-strain":[304],"model":[310],"highly":[313],"complex":[314],"biological":[315],"structure.":[316]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}