{"id":"https://openalex.org/W2593683051","doi":"https://doi.org/10.1117/12.2254680","title":"Identification and characterization of neutrophil extracellular trap shapes in flow cytometry","display_name":"Identification and characterization of neutrophil extracellular trap shapes in flow cytometry","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2593683051","doi":"https://doi.org/10.1117/12.2254680","mag":"2593683051"},"language":"en","primary_location":{"id":"doi:10.1117/12.2254680","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254680","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041397853","display_name":"Brandon Ginley","orcid":null},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brandon Ginley","raw_affiliation_strings":["Univ. at Buffalo (United States)"],"affiliations":[{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072224019","display_name":"Tiffany R. Emmons","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Emmons","raw_affiliation_strings":["Roswell Park Cancer Institute (United States)"],"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute (United States)","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090612855","display_name":"Prabhu Sasankan","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prabhu Sasankan","raw_affiliation_strings":["Roswell Park Cancer Institute (United States)"],"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute (United States)","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071156013","display_name":"Constantin F. Urban","orcid":"https://orcid.org/0000-0003-1438-1134"},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Constantin Urban","raw_affiliation_strings":["Ume\u00e5 Univ. (Sweden)"],"affiliations":[{"raw_affiliation_string":"Ume\u00e5 Univ. (Sweden)","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059770078","display_name":"Brahm H. Segal","orcid":"https://orcid.org/0000-0001-5043-7380"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brahm H. Segal","raw_affiliation_strings":["Roswell Park Cancer Institute (United States)","Univ. at Buffalo (United States)"],"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute (United States)","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044061952","display_name":"Pinaki Sarder","orcid":"https://orcid.org/0000-0003-2450-5233"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pinaki Sarder","raw_affiliation_strings":["Univ. at Buffalo (United States)"],"affiliations":[{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041397853"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01993199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10140","issue":null,"first_page":"101400D","last_page":"101400D"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"Neutrophil extracellular traps","score":0.9194166660308838},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6528096795082092},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6488156318664551},{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.6081554889678955},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5426216125488281},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.49611935019493103},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.48361435532569885},{"id":"https://openalex.org/keywords/histogram","display_name":"Histogram","score":0.4350598454475403},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.4323732554912567},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"Flow cytometry","score":0.4284510612487793},{"id":"https://openalex.org/keywords/cytometry","display_name":"Cytometry","score":0.42714983224868774},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.38475704193115234},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.2981777489185333},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23168382048606873},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.16696131229400635}],"concepts":[{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.9194166660308838},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6528096795082092},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6488156318664551},{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.6081554889678955},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5426216125488281},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.49611935019493103},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.48361435532569885},{"id":"https://openalex.org/C53533937","wikidata":"https://www.wikidata.org/wiki/Q185020","display_name":"Histogram","level":3,"score":0.4350598454475403},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.4323732554912567},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4284510612487793},{"id":"https://openalex.org/C2780339063","wikidata":"https://www.wikidata.org/wiki/Q5201367","display_name":"Cytometry","level":3,"score":0.42714983224868774},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.38475704193115234},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.2981777489185333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23168382048606873},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16696131229400635},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2254680","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254680","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337942","display_name":"Jacobs School of Medicine and Biomedical Sciences, University at Buffalo","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W230295452","https://openalex.org/W2001412060","https://openalex.org/W2010629543","https://openalex.org/W2078817520","https://openalex.org/W2104934425","https://openalex.org/W2107089652","https://openalex.org/W2137625680","https://openalex.org/W2171033594","https://openalex.org/W2461036323","https://openalex.org/W4229921563","https://openalex.org/W4238793777","https://openalex.org/W4302805316","https://openalex.org/W6633435507","https://openalex.org/W6718423416","https://openalex.org/W7027716524","https://openalex.org/W7029391333"],"related_works":["https://openalex.org/W2036949254","https://openalex.org/W2122667464","https://openalex.org/W2054831422","https://openalex.org/W2106731176","https://openalex.org/W2387104004","https://openalex.org/W3047671631","https://openalex.org/W1548186045","https://openalex.org/W2902098370","https://openalex.org/W2147223569","https://openalex.org/W4283267580"],"abstract_inverted_index":{"Neutrophil":[0],"extracellular":[1],"trap":[2],"(NET)":[3],"formation":[4],"is":[5,30,35,43,158,168,189,212],"an":[6,118],"alternate":[7],"immunologic":[8],"weapon":[9],"used":[10,44,87],"mainly":[11],"by":[12,175],"neutrophils.":[13],"Chromatin":[14],"backbones":[15],"fused":[16],"with":[17,246,249],"proteins":[18],"derived":[19],"from":[20,199],"granules":[21],"are":[22,95,105],"shot":[23],"like":[24],"projectiles":[25],"onto":[26],"foreign":[27],"invaders.":[28],"It":[29],"thought":[31],"that":[32],"this":[33],"mechanism":[34],"highly":[36],"anti-microbial,":[37],"aids":[38],"in":[39,70,146],"preventing":[40],"bacterial":[41],"dissemination,":[42],"to":[45,67,88,100,107,142,160,164,225,238],"break":[46],"down":[47],"structures":[48],"several":[49,58],"sizes":[50],"larger":[51],"than":[52,215],"neutrophils":[53,200],"themselves,":[54],"and":[55,83,98,113,125,211,235,251],"may":[56],"have":[57,64],"more":[59],"uses":[60,136],"yet":[61],"unknown.":[62],"NETs":[63,109,198,243],"been":[65],"implied":[66],"be":[68,223],"involved":[69],"a":[71,130],"wide":[72],"array":[73],"of":[74,179,185,242],"systemic":[75],"host":[76],"immune":[77],"defenses,":[78],"including":[79],"sepsis,":[80],"autoimmune":[81],"diseases,":[82],"cancer.":[84],"Existing":[85],"methods":[86],"visually":[89],"quantify":[90],"NETotic":[91],"versus":[92],"non-NETotic":[93],"shapes":[94,127],"extremely":[96],"time-consuming":[97],"subject":[99],"user":[101],"bias.":[102],"These":[103],"limitations":[104],"obstacles":[106],"developing":[108],"as":[110],"prognostic":[111],"biomarkers":[112],"therapeutic":[114],"targets.":[115],"We":[116],"propose":[117],"automated":[119],"pipeline":[120],"for":[121,232,244],"quantitatively":[122],"detecting":[123],"neutrophil":[124],"NET":[126,233],"captured":[128],"using":[129,191],"flow":[131],"cytometry-imaging":[132],"system.":[133],"Our":[134,195,220],"method":[135,196,221],"contrast":[137,152],"limited":[138],"adaptive":[139],"histogram":[140],"equalization":[141],"improve":[143],"signal":[144],"intensity":[145],"dimly":[147],"illuminated":[148],"NETs.":[149],"From":[150],"the":[151,162,171,180,186,240],"improved":[153],"image,":[154,174],"fixed":[155],"value":[156],"thresholding":[157],"applied":[159],"convert":[161],"image":[163],"binary.":[165],"Feature":[166],"extraction":[167],"performed":[169,190],"on":[170,206],"resulting":[172,181,187],"binary":[173],"calculating":[176],"region":[177],"properties":[178],"foreground":[182],"structures.":[183],"Classification":[184],"features":[188],"Support":[192],"Vector":[193],"Machine.":[194],"classifies":[197],"without":[201],"traps":[202],"at":[203],"0.97/0.96":[204],"sensitivity/specificity":[205],"n":[207],"=":[208],"387":[209],"images,":[210],"1500X":[213],"faster":[214],"manual":[216],"classification,":[217,234],"per":[218],"sample.":[219],"can":[222],"extended":[224],"rapidly":[226],"analyze":[227],"whole-slide":[228],"immunofluorescence":[229],"tissue":[230],"images":[231],"has":[236],"potential":[237],"streamline":[239],"quantification":[241],"patients":[245],"diseases":[247],"associated":[248],"cancer":[250],"autoimmunity.":[252]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
