{"id":"https://openalex.org/W2309194145","doi":"https://doi.org/10.1117/12.2217286","title":"Quantitative diagnosis of tongue cancer from histological images in an animal model","display_name":"Quantitative diagnosis of tongue cancer from histological images in an animal model","publication_year":2016,"publication_date":"2016-03-23","ids":{"openalex":"https://openalex.org/W2309194145","doi":"https://doi.org/10.1117/12.2217286","mag":"2309194145","pmid":"https://pubmed.ncbi.nlm.nih.gov/27656036"},"language":"en","primary_location":{"id":"doi:10.1117/12.2217286","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2217286","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057729645","display_name":"Guolan Lu","orcid":"https://orcid.org/0000-0002-5023-3465"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guolan Lu","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA","Georgia Institute of Technology (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021103445","display_name":"Xulei Qin","orcid":"https://orcid.org/0000-0001-9248-4230"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xulei Qin","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529895","display_name":"Dongsheng Wang","orcid":"https://orcid.org/0000-0002-6638-3783"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongsheng Wang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006034357","display_name":"Susan M\u00fcller","orcid":"https://orcid.org/0000-0003-3620-979X"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Muller","raw_affiliation_strings":["Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA","Emory Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083667162","display_name":"Hongzheng Zhang","orcid":"https://orcid.org/0000-0001-8105-2256"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongzheng Zhang","raw_affiliation_strings":["Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA","Emory Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399060","display_name":"Amy Chen","orcid":"https://orcid.org/0000-0003-0244-9592"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Chen","raw_affiliation_strings":["Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA","Emory Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085137065","display_name":"Zhuo G. Chen","orcid":"https://orcid.org/0000-0002-2572-1926"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo G. Chen","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083707303","display_name":"Baowei Fei","orcid":"https://orcid.org/0000-0002-9123-9484"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baowei Fei","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; Department of Mathematics & Computer Science, Emory University, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; Department of Mathematics & Computer Science, Emory University, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":[]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5057729645"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"],"apc_list":null,"apc_paid":null,"fwci":0.1749,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55198584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9791","issue":null,"first_page":"97910L","last_page":"97910L"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.9732999801635742,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tongue","display_name":"Tongue","score":0.8574612736701965},{"id":"https://openalex.org/keywords/h-e-stain","display_name":"H&E stain","score":0.711834192276001},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.6049330234527588},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5741879343986511},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45537811517715454},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44792884588241577},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.36729180812835693},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3416290879249573},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.24262389540672302},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07666659355163574}],"concepts":[{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.8574612736701965},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.711834192276001},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6049330234527588},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5741879343986511},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45537811517715454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44792884588241577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36729180812835693},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3416290879249573},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.24262389540672302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07666659355163574}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2217286","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2217286","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:27656036","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27656036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:3985536","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5028209","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W244253826","https://openalex.org/W1003639975","https://openalex.org/W1965129247","https://openalex.org/W1975956815","https://openalex.org/W1978207693","https://openalex.org/W2015346646","https://openalex.org/W2022237253","https://openalex.org/W2033555065","https://openalex.org/W2048881835","https://openalex.org/W2057034562","https://openalex.org/W2069330528","https://openalex.org/W2076797886","https://openalex.org/W2087699177","https://openalex.org/W2103243046","https://openalex.org/W2113530039","https://openalex.org/W2154053567","https://openalex.org/W2155423555","https://openalex.org/W2156398782","https://openalex.org/W2160850953","https://openalex.org/W2163352848","https://openalex.org/W2217602394","https://openalex.org/W2278837653","https://openalex.org/W2330820318","https://openalex.org/W2911964244","https://openalex.org/W4234793439","https://openalex.org/W4252278281","https://openalex.org/W6609464047","https://openalex.org/W6641611612","https://openalex.org/W6655950799","https://openalex.org/W6658989607","https://openalex.org/W6694770138","https://openalex.org/W6738852829","https://openalex.org/W6843735874"],"related_works":["https://openalex.org/W3136794468","https://openalex.org/W1986945230","https://openalex.org/W2367950022","https://openalex.org/W2365707941","https://openalex.org/W2366141844","https://openalex.org/W2383946220","https://openalex.org/W2358428239","https://openalex.org/W3055032190","https://openalex.org/W3011636953","https://openalex.org/W4398835687"],"abstract_inverted_index":{"We":[0],"developed":[1],"a":[2,9,133],"chemically-induced":[3],"oral":[4],"cancer":[5,15,139],"animal":[6,18],"model":[7,19],"and":[8,45,58,75,87,104,108,132],"computer":[10,156],"aided":[11,157],"method":[12,125],"for":[13,38,55,137,155],"tongue":[14,51,138,160],"diagnosis.":[16],"The":[17,61,96,141],"allows":[20],"us":[21],"to":[22,113,148,152],"monitor":[23],"the":[24,27,93,115,124],"progress":[25],"of":[26,43,69,82,98,130,135,144,159],"lesions":[28],"over":[29],"time.":[30],"Tongue":[31],"tissue":[32,49,78,103,154],"dissected":[33],"from":[34,50,92,101],"mice":[35],"was":[36],"sent":[37],"histological":[39,94],"processing.":[40],"Representative":[41],"areas":[42],"hematoxylin":[44],"eosin":[46],"(H&E)":[47],"stained":[48],"sections":[52],"were":[53,90],"captured":[54],"classifying":[56],"tumor":[57,74],"non-tumor":[59],"tissue.":[60],"image":[62,99],"set":[63],"used":[64],"in":[65],"this":[66,145,150],"paper":[67],"consisted":[68],"214":[70],"color":[71],"images":[72],"(114":[73],"100":[76],"normal":[77],"samples).":[79],"A":[80],"total":[81],"738":[83],"color,":[84],"texture,":[85],"morphometry":[86],"topology":[88],"features":[89,100],"extracted":[91],"images.":[95],"combination":[97],"epithelium":[102],"its":[105],"constituent":[106],"nuclei":[107],"cytoplasm":[109],"has":[110],"been":[111],"demonstrated":[112],"improve":[114],"classification":[116],"results.":[117],"With":[118],"ten":[119],"iteration":[120],"nested":[121],"cross":[122],"validation,":[123],"achieved":[126],"an":[127],"average":[128],"sensitivity":[129],"96.5%":[131],"specificity":[134],"99%":[136],"detection.":[140],"next":[142],"step":[143],"research":[146],"is":[147],"apply":[149],"approach":[151],"human":[153],"diagnosis":[158],"cancer.":[161]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}