{"id":"https://openalex.org/W2074330269","doi":"https://doi.org/10.1117/12.2082264","title":"Inter-observer variability in the classification of ovarian cancer cell type using microscopy: a pilot study","display_name":"Inter-observer variability in the classification of ovarian cancer cell type using microscopy: a pilot study","publication_year":2015,"publication_date":"2015-03-19","ids":{"openalex":"https://openalex.org/W2074330269","doi":"https://doi.org/10.1117/12.2082264","mag":"2074330269"},"language":"en","primary_location":{"id":"doi:10.1117/12.2082264","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082264","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039348485","display_name":"Marios A. Gavrielides","orcid":null},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marios A. Gavrielides","raw_affiliation_strings":["U.S. Food and Drug Administration (United States)","U.S. Food and Drug Administration  (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Food and Drug Administration (United States)","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"U.S. Food and Drug Administration  (United States)","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111445978","display_name":"Brigitte M. Ronnett","orcid":null},"institutions":[{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brigitte M. Ronnett","raw_affiliation_strings":["The Johns Hopkins Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Hospital (United States)","institution_ids":["https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041625714","display_name":"Russell Vang","orcid":"https://orcid.org/0000-0002-7255-7743"},"institutions":[{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell Vang","raw_affiliation_strings":["The Johns Hopkins Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Hospital (United States)","institution_ids":["https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067488694","display_name":"Jeffrey D. Seidman","orcid":null},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Seidman","raw_affiliation_strings":["U.S. Food and Drug Administration (United States)","U.S. Food and Drug Administration  (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Food and Drug Administration (United States)","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"U.S. Food and Drug Administration  (United States)","institution_ids":["https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4156,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75301928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"9420","issue":null,"first_page":"94200D","last_page":"94200D"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9386000037193298,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.6466718316078186},{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.5339630246162415},{"id":"https://openalex.org/keywords/clear-cell","display_name":"Clear cell","score":0.5121164321899414},{"id":"https://openalex.org/keywords/clear-cell-carcinoma","display_name":"Clear cell carcinoma","score":0.479801207780838},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4719504415988922},{"id":"https://openalex.org/keywords/serous-fluid","display_name":"Serous fluid","score":0.45203864574432373},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.4471049904823303},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.44164007902145386},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.37968406081199646},{"id":"https://openalex.org/keywords/carcinoma","display_name":"Carcinoma","score":0.3736349940299988},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3475196063518524},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.31122201681137085},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18226996064186096},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1298789381980896}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6466718316078186},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5339630246162415},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.5121164321899414},{"id":"https://openalex.org/C2781199814","wikidata":"https://www.wikidata.org/wiki/Q18556242","display_name":"Clear cell carcinoma","level":3,"score":0.479801207780838},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4719504415988922},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.45203864574432373},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4471049904823303},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44164007902145386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37968406081199646},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3736349940299988},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3475196063518524},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31122201681137085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18226996064186096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1298789381980896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2082264","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082264","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5699999928474426}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1967414409","https://openalex.org/W1983982275","https://openalex.org/W1996737831","https://openalex.org/W2011065238","https://openalex.org/W2055344345","https://openalex.org/W2078437730","https://openalex.org/W2088899370","https://openalex.org/W2129355295","https://openalex.org/W3142150957","https://openalex.org/W4229759000","https://openalex.org/W6608147154","https://openalex.org/W6684829588"],"related_works":["https://openalex.org/W2953763871","https://openalex.org/W2052423144","https://openalex.org/W2050466777","https://openalex.org/W2902542393","https://openalex.org/W1577593758","https://openalex.org/W1556814579","https://openalex.org/W1979879868","https://openalex.org/W3096314415","https://openalex.org/W1025140297","https://openalex.org/W2000158821"],"abstract_inverted_index":{"Studies":[0],"have":[1,10],"shown":[2],"that":[3,18,194],"different":[4,11,15,29,33],"cell":[5,26,39,51,77,119,131,150,188],"types":[6,27,52,78,151,189],"of":[7,47,57,74,89,106,138,157,212,230,259],"ovarian":[8,49,75,107],"carcinoma":[9],"molecular":[12],"profiles,":[13],"exhibit":[14],"behavior,":[16],"and":[17,32,79,141,186,228,236],"patients":[19],"could":[20],"benefit":[21],"from":[22],"typespecific":[23],"treatment.":[24],"Different":[25],"display":[28],"histopathology":[30],"features,":[31],"criteria":[34],"are":[35],"used":[36,222],"for":[37,44,84,93,115,133,142,172,261],"each":[38],"type":[40],"classification.":[41],"Inter-observer":[42],"variability":[43,69],"the":[45,72,129,173,210,226,241,247,257],"task":[46],"classifying":[48],"cancer":[50,76,108],"is":[53,206],"an":[54],"under-examined":[55],"area":[56],"research.":[58],"This":[59],"study":[60,65,88,233],"served":[61],"as":[62],"a":[63,86,153,199,232],"pilot":[64],"to":[66,71,80,208,223,255],"quantify":[67],"observer":[68],"related":[70],"classification":[73],"extract":[81],"valuable":[82],"data":[83],"designing":[85],"validation":[87],"digital":[90,237],"pathology":[91,102],"(DP)":[92],"this":[94,262],"task.":[95,263],"Three":[96],"observers":[97,164],"with":[98,109,112,152],"expertise":[99],"in":[100,215,225,245,253],"gynecologic":[101],"reviewed":[103],"114":[104],"cases":[105,123,135,144],"optical":[110,235],"microscopy,":[111],"specific":[113],"guidelines":[114],"classifications":[116],"into":[117],"distinct":[118],"types.":[120],"For":[121],"93":[122],"all":[124,162],"3":[125,139,143],"pathologists":[126,260],"agreed":[127],"on":[128],"same":[130],"type,":[132],"18":[134],"2":[136],"out":[137],"agreed,":[140],"there":[145],"was":[146,165],"no":[147],"agreement.":[148],"Across":[149],"minimum":[154],"sample":[155],"size":[156],"10":[158],"cases,":[159],"agreement":[160,196,258],"between":[161],"three":[163],"{91.1%,":[166],"80.0%,":[167],"90.0%,":[168],"78.6%,":[169],"100.0%,":[170],"61.5%}":[171],"high":[174],"grade":[175,179],"serous":[176,180],"carcinoma,":[177,181],"low":[178],"endometrioid,":[182],"mucinous,":[183],"clear":[184],"cell,":[185],"carcinosarcoma":[187],"respectively.":[190],"These":[191,218],"results":[192,219,242],"indicate":[193],"unanimous":[195],"varied":[197],"over":[198],"fairly":[200],"wide":[201],"range.":[202],"However,":[203],"additional":[204],"research":[205],"needed":[207],"determine":[209],"importance":[211],"these":[213],"differences":[214],"comparison":[216],"studies.":[217],"will":[220,243],"be":[221],"aid":[224],"design":[227],"sizing":[229],"such":[231],"comparing":[234],"pathology.":[238],"In":[239],"addition,":[240],"help":[244],"understanding":[246],"potential":[248],"role":[249],"computer-aided":[250],"diagnosis":[251],"has":[252],"helping":[254],"improve":[256]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}