{"id":"https://openalex.org/W2087199537","doi":"https://doi.org/10.1117/12.2006619","title":"Quantitative analysis of TDLUs using adaptive morphological shape techniques","display_name":"Quantitative analysis of TDLUs using adaptive morphological shape techniques","publication_year":2013,"publication_date":"2013-03-29","ids":{"openalex":"https://openalex.org/W2087199537","doi":"https://doi.org/10.1117/12.2006619","mag":"2087199537","pmid":"https://pubmed.ncbi.nlm.nih.gov/25722829"},"language":"en","primary_location":{"id":"doi:10.1117/12.2006619","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2006619","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023922141","display_name":"Adrian Rosebrock","orcid":"https://orcid.org/0000-0001-7688-6299"},"institutions":[{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrian Rosebrock","raw_affiliation_strings":["University of Maryland, Baltimore County","University of Maryland, Baltimore County, United States"],"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore County","institution_ids":["https://openalex.org/I79272384"]},{"raw_affiliation_string":"University of Maryland, Baltimore County, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101046136","display_name":"Jesus J. Caban","orcid":null},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]},{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus J. Caban","raw_affiliation_strings":["National Intrepid Center of Excellence, Naval Medical Center","Walter Reed National Military Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"National Intrepid Center of Excellence, Naval Medical Center","institution_ids":["https://openalex.org/I1312537475"]},{"raw_affiliation_string":"Walter Reed National Military Medical Ctr. (United States)","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024821010","display_name":"Jonine D. Figueroa","orcid":"https://orcid.org/0000-0002-5100-623X"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonine Figueroa","raw_affiliation_strings":["Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH)","National Cancer Institute, National Institutes of Health (United States)"],"affiliations":[{"raw_affiliation_string":"Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH)","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052880291","display_name":"Gretchen L. Gierach","orcid":"https://orcid.org/0000-0002-0165-5522"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen Gierach","raw_affiliation_strings":["Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH)","National Cancer Institute, National Institutes of Health (United States)"],"affiliations":[{"raw_affiliation_string":"Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH)","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051854635","display_name":"Laura Linville","orcid":"https://orcid.org/0000-0001-6993-3421"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Linville","raw_affiliation_strings":["Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH)","National Cancer Institute, National Institutes of Health (United States)"],"affiliations":[{"raw_affiliation_string":"Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH)","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011055578","display_name":"Stephen M. Hewitt","orcid":"https://orcid.org/0000-0001-8283-1788"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Hewitt","raw_affiliation_strings":["Applied Molecular Pathology Lab (AMPL), NCI, NIH","Applied Molecular Pathology Lab., National Cancer Institute, National Institutes of Health  (United States)"],"affiliations":[{"raw_affiliation_string":"Applied Molecular Pathology Lab (AMPL), NCI, NIH","institution_ids":[]},{"raw_affiliation_string":"Applied Molecular Pathology Lab., National Cancer Institute, National Institutes of Health  (United States)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108095498","display_name":"Mark E. Sherman","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Sherman","raw_affiliation_strings":["Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH) ; Applied Molecular Pathology Lab (AMPL), NCI, NIH","Applied Molecular Pathology Lab., National Cancer Institute, National Institutes of Health  (United States)"],"affiliations":[{"raw_affiliation_string":"Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH) ; Applied Molecular Pathology Lab (AMPL), NCI, NIH","institution_ids":[]},{"raw_affiliation_string":"Applied Molecular Pathology Lab., National Cancer Institute, National Institutes of Health  (United States)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023922141"],"corresponding_institution_ids":["https://openalex.org/I79272384"],"apc_list":null,"apc_paid":null,"fwci":1.9327,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8835002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8676","issue":null,"first_page":"86760N","last_page":"86760N"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9455000162124634,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5997269153594971},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3209986090660095}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5997269153594971},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3209986090660095}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2006619","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2006619","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:25722829","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25722829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:3303631","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4339025","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2098132831","https://openalex.org/W2115806400","https://openalex.org/W2142094270","https://openalex.org/W2150959753"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W2382290278","https://openalex.org/W4395014643"],"abstract_inverted_index":{"Within":[0],"the":[1,6,14,108,115,131,175,199,207,211,227,236,239],"complex":[2],"branching":[3],"system":[4],"of":[5,31,60,92,110,119,142,162,184,210,229],"breast,":[7],"terminal":[8],"duct":[9],"lobular":[10],"units":[11],"(TDLUs)":[12],"are":[13,56],"anatomical":[15],"location":[16],"where":[17],"most":[18],"cancer":[19],"originates.":[20],"With":[21],"aging,":[22],"TDLUs":[23,121,167],"undergo":[24],"physiological":[25],"involution,":[26],"reflected":[27],"in":[28,38,122,130,149,174],"a":[29,36,85,90,143,159],"loss":[30],"structural":[32,208],"components":[33],"(acini)":[34],"and":[35,95,103,137,182,189,217,242],"reduction":[37],"total":[39],"number.":[40],"Data":[41],"suggest":[42],"that":[43,49,153,225],"women":[44],"undergoing":[45],"benign":[46],"breast":[47,62,123],"biopsies":[48,169],"do":[50],"not":[51],"show":[52,152],"age":[53],"appropriate":[54],"involution":[55],"at":[57],"increased":[58],"risk":[59],"developing":[61],"cancer.":[63],"To":[64,106],"date,":[65],"TDLU":[66,232,237],"assessments":[67],"have":[68],"generally":[69],"been":[70],"made":[71],"by":[72,78,128,213],"qualitative":[73],"visual":[74,194],"assessment,":[75],"rather":[76],"than":[77],"objective":[79],"quantitative":[80,93],"analysis.":[81],"This":[82],"paper":[83],"introduces":[84],"technique":[86],"to":[87,99,140,151,158,201],"automatically":[88],"estimate":[89],"set":[91],"measurements":[94],"use":[96],"those":[97,141],"variables":[98],"more":[100],"objectively":[101],"describe":[102],"classify":[104],"TDLUs.":[105],"validate":[107],"accuracy":[109],"our":[111,154,221],"system,":[112],"we":[113,164,197,223],"compared":[114,138],"computer-based":[116],"morphological":[117],"properties":[118,209],"51":[120],"tissues":[124],"donated":[125],"for":[126,171],"research":[127],"volunteers":[129],"Susan":[132],"G.":[133],"Komen":[134],"Tissue":[135],"Bank":[136],"results":[139],"pathologist,":[144],"demonstrating":[145],"70%":[146],"agreement.":[147],"Secondly,":[148],"order":[150],"method":[155],"is":[156],"applicable":[157],"wider":[160],"range":[161],"datasets,":[163],"analyzed":[165],"52":[166],"from":[168],"performed":[170],"clinical":[172],"indications":[173],"National":[176],"Cancer":[177],"Institute's":[178],"Breast":[179],"Radiology":[180],"Evaluation":[181],"Study":[183],"Tissues":[185],"(BREAST)":[186],"Stamp":[187],"Project":[188],"obtained":[190],"82%":[191],"correlation":[192],"with":[193,235],"assessment.":[195],"Lastly,":[196],"demonstrate":[198],"ability":[200],"uncover":[202],"novel":[203],"measures":[204],"when":[205],"researching":[206],"acini":[212,230],"applying":[214],"machine":[215],"learning":[216],"clustering":[218],"techniques.":[219],"Through":[220],"study":[222],"found":[224],"while":[226],"number":[228],"per":[231],"increases":[233],"exponentially":[234],"diameter,":[238],"average":[240],"elongation":[241],"roundness":[243],"remain":[244],"constant.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}