{"id":"https://openalex.org/W2034361718","doi":"https://doi.org/10.1117/12.877543","title":"Probabilistic framework for subject-specific and population-based analysis of longitudinal changes and disease progression in brain MR images","display_name":"Probabilistic framework for subject-specific and population-based analysis of longitudinal changes and disease progression in brain MR images","publication_year":2011,"publication_date":"2011-03-03","ids":{"openalex":"https://openalex.org/W2034361718","doi":"https://doi.org/10.1117/12.877543","mag":"2034361718"},"language":"en","primary_location":{"id":"doi:10.1117/12.877543","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.877543","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079965425","display_name":"Annemie Ribbens","orcid":"https://orcid.org/0000-0002-5732-5389"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Annemie Ribbens","raw_affiliation_strings":["Katholieke Univ. Leuven (Belgium)","Katholieke University, Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Katholieke Univ. Leuven (Belgium)","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008370723","display_name":"Jeroen Hermans","orcid":"https://orcid.org/0000-0001-5279-316X"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeroen Hermans","raw_affiliation_strings":["Katholieke Univ. Leuven (Belgium)","Katholieke University, Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Katholieke Univ. Leuven (Belgium)","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035651557","display_name":"Frederik Maes","orcid":"https://orcid.org/0000-0003-0027-1479"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frederik Maes","raw_affiliation_strings":["Katholieke Univ. Leuven (Belgium)","Katholieke University, Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Katholieke Univ. Leuven (Belgium)","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085220186","display_name":"Dirk Vandermeulen","orcid":"https://orcid.org/0000-0002-4052-5296"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dirk Vandermeulen","raw_affiliation_strings":["Katholieke Univ. Leuven (Belgium)","Katholieke University, Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Katholieke Univ. Leuven (Belgium)","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017232974","display_name":"Paul Suetens","orcid":"https://orcid.org/0000-0003-1301-0884"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Paul Suetens","raw_affiliation_strings":["Katholieke Univ. Leuven (Belgium)","Katholieke University, Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Katholieke Univ. Leuven (Belgium)","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5079965425"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10323509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7962","issue":null,"first_page":"796219","last_page":"796219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.6921800971031189},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6660022735595703},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6275895237922668},{"id":"https://openalex.org/keywords/atlas","display_name":"Atlas (anatomy)","score":0.6262712478637695},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.603800892829895},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.5747448801994324},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5461429953575134},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.49622756242752075},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.47647497057914734},{"id":"https://openalex.org/keywords/expectation\u2013maximization-algorithm","display_name":"Expectation\u2013maximization algorithm","score":0.4709171950817108},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4299096465110779},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4172346293926239},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36341917514801025},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16453427076339722},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14969080686569214},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.12245932221412659},{"id":"https://openalex.org/keywords/maximum-likelihood","display_name":"Maximum likelihood","score":0.08468139171600342}],"concepts":[{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.6921800971031189},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6660022735595703},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6275895237922668},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.6262712478637695},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.603800892829895},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.5747448801994324},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5461429953575134},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.49622756242752075},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.47647497057914734},{"id":"https://openalex.org/C182081679","wikidata":"https://www.wikidata.org/wiki/Q1275153","display_name":"Expectation\u2013maximization algorithm","level":3,"score":0.4709171950817108},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4299096465110779},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4172346293926239},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36341917514801025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16453427076339722},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14969080686569214},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12245932221412659},{"id":"https://openalex.org/C49781872","wikidata":"https://www.wikidata.org/wiki/Q1045555","display_name":"Maximum likelihood","level":2,"score":0.08468139171600342},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.877543","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.877543","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/290361","is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/bitstream/123456789/290361/2/3100.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SPIE medical imaging 2011 conference, Lake Buena Vista - Orlando, Florida, USA, 12-17 February 2011","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2314146950","https://openalex.org/W2011187995","https://openalex.org/W2373521488","https://openalex.org/W2324878645","https://openalex.org/W2803101231","https://openalex.org/W4284509","https://openalex.org/W4393084406","https://openalex.org/W2785984867","https://openalex.org/W2553519758","https://openalex.org/W2108727084"],"abstract_inverted_index":{"Aging":[0],"and":[1,14,46,57,83,90,106,182,196],"many":[2,30],"neurological":[3,72],"diseases":[4],"cause":[5],"progressive":[6],"changes":[7],"in":[8,29,95,172],"brain":[9,62,104,135,156],"morphology.":[10],"Both":[11],"subject-specific":[12,44,56,184],"detection":[13],"measurement":[15],"of":[16,26,60,66,113,127,143,161,221],"these":[17,177],"changes,":[18],"as":[19,21,40],"well":[20],"their":[22,118],"population-based":[23,41,58,125],"analysis":[24,45,59,126],"are":[25,36],"great":[27],"interest":[28],"clinical":[31],"studies.":[32],"Generally,":[33],"both":[34,180],"problems":[35],"handled":[37],"separately.":[38],"However,":[39],"knowledge":[42],"facilitates":[43],"vice":[47],"versa,":[48],"we":[49],"propose":[50],"a":[51,78,80,100,124,140,167,206],"unified":[52],"statistical":[53,174],"framework":[54],"for":[55],"longitudinal":[61],"MR":[63],"image":[64,164],"sequences":[65],"subjects":[67],"suffering":[68],"from":[69],"the":[70,84,109,114,128,154,173,198],"same":[71],"disease.":[73],"The":[74,147,201],"proposed":[75],"method":[76,202],"uses":[77],"maximum":[79],"posteriori":[81],"formulation":[82],"expectation":[85],"maximization":[86],"algorithm":[87],"to":[88,111,116,122,166],"simultaneously":[89,151],"iteratively":[91],"segment":[92],"all":[93],"images":[94,115],"separate":[96],"tissue":[97],"classes,":[98],"construct":[99],"global":[101],"probabilistic":[102,134],"3D":[103,155],"atlas":[105,110,136,149,157],"non-rigidly":[107],"deform":[108],"each":[112,162],"guide":[117],"segmentation.":[119],"In":[120],"order":[121],"enable":[123,179],"disease":[129,144,169,185,194],"progression,":[130],"an":[131],"intermediate":[132],"4D":[133,148],"is":[137,150,203],"introduced,":[138],"representing":[139],"discrete":[141],"set":[142,210],"progression":[145,170,186,195],"stages.":[146],"constructed":[152],"with":[153],"by":[158],"incorporating":[159],"assignments":[160,178],"input":[163],"(voxelwise)":[165],"particular":[168],"stage":[171],"framework.":[175],"Moreover,":[176],"temporal":[181],"spatial":[183],"analysis.":[187],"This":[188],"includes":[189],"detecting":[190],"delayed":[191],"or":[192],"advanced":[193],"indicating":[197],"affected":[199],"regions.":[200],"validated":[204],"on":[205,211],"publicly":[207],"available":[208],"data":[209],"which":[212],"it":[213],"shows":[214],"promising":[215],"results.":[216],"\u00a9":[217],"2011":[218],"Copyright":[219],"Society":[220],"Photo-Optical":[222],"Instrumentation":[223],"Engineers":[224],"(SPIE).":[225]},"counts_by_year":[],"updated_date":"2026-02-09T09:26:11.010843","created_date":"2025-10-10T00:00:00"}