{"id":"https://openalex.org/W2006437150","doi":"https://doi.org/10.1117/12.772352","title":"Dynamic dosimetry and edema detection in prostate brachytherapy: a complete system","display_name":"Dynamic dosimetry and edema detection in prostate brachytherapy: a complete system","publication_year":2008,"publication_date":"2008-03-06","ids":{"openalex":"https://openalex.org/W2006437150","doi":"https://doi.org/10.1117/12.772352","mag":"2006437150"},"language":"en","primary_location":{"id":"doi:10.1117/12.772352","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.772352","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100661347","display_name":"Abhishek Jain","orcid":"https://orcid.org/0000-0002-3572-7643"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Jain","raw_affiliation_strings":["Johns Hopkins Univ. (United States)","Johns Hopkins University ("],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060559135","display_name":"Anton Deguet","orcid":"https://orcid.org/0000-0003-3856-2095"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Deguet","raw_affiliation_strings":["Johns Hopkins Univ. (United States)","Johns Hopkins University ("],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063913520","display_name":"Iulian Iordachita","orcid":"https://orcid.org/0000-0002-2510-9008"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Iordachita","raw_affiliation_strings":["Johns Hopkins Univ. (United States)","Johns Hopkins University ("],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047367765","display_name":"Gouthami Chintalapani","orcid":"https://orcid.org/0000-0001-5087-4062"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Chintalapani","raw_affiliation_strings":["Johns Hopkins Univ. (United States)","Johns Hopkins University ("],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023853535","display_name":"J. Blevins","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142356","display_name":"Acoustic MedSystems (United States)","ror":"https://ror.org/049hfye85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Blevins","raw_affiliation_strings":["Acoustic MedSystems, Inc. (United States)","Acoustic MedSystems, Inc"],"affiliations":[{"raw_affiliation_string":"Acoustic MedSystems, Inc. (United States)","institution_ids":["https://openalex.org/I4210142356"]},{"raw_affiliation_string":"Acoustic MedSystems, Inc","institution_ids":["https://openalex.org/I4210142356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044796422","display_name":"Yi Le","orcid":"https://orcid.org/0000-0003-0393-0214"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Le","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075249560","display_name":"Elwood Armour","orcid":null},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Armour","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079073363","display_name":"Clif Burdette","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142356","display_name":"Acoustic MedSystems (United States)","ror":"https://ror.org/049hfye85","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Burdette","raw_affiliation_strings":["Acoustic MedSystems, Inc. (United States)","Acoustic MedSystems, Inc"],"affiliations":[{"raw_affiliation_string":"Acoustic MedSystems, Inc. (United States)","institution_ids":["https://openalex.org/I4210142356"]},{"raw_affiliation_string":"Acoustic MedSystems, Inc","institution_ids":["https://openalex.org/I4210142356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010125684","display_name":"D. Song","orcid":"https://orcid.org/0000-0003-4133-0455"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Song","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091634762","display_name":"G. Fichtinger","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G. Fichtinger","raw_affiliation_strings":["Queen's Univ. (Canada)","Queen's Univ.,   Canada"],"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Queen's Univ.,   Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100661347"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.3868,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.659274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"6918","issue":null,"first_page":"69181Y","last_page":"69181Y"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brachytherapy","display_name":"Brachytherapy","score":0.8669941425323486},{"id":"https://openalex.org/keywords/prostate-brachytherapy","display_name":"Prostate brachytherapy","score":0.7004067301750183},{"id":"https://openalex.org/keywords/dosimetry","display_name":"Dosimetry","score":0.6908265948295593},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5659356117248535},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.5140489339828491},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.5082187652587891},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.46885713934898376},{"id":"https://openalex.org/keywords/edema","display_name":"Edema","score":0.4197218120098114},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.39044564962387085},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.3089359402656555},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3056706190109253},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.20385003089904785},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.19818535447120667}],"concepts":[{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.8669941425323486},{"id":"https://openalex.org/C2778648096","wikidata":"https://www.wikidata.org/wiki/Q17009878","display_name":"Prostate brachytherapy","level":4,"score":0.7004067301750183},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.6908265948295593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5659356117248535},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5140489339828491},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5082187652587891},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.46885713934898376},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4197218120098114},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.39044564962387085},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3089359402656555},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3056706190109253},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20385003089904785},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19818535447120667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.772352","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.772352","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6299999952316284}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W100491968","https://openalex.org/W1660302799","https://openalex.org/W1943228898","https://openalex.org/W1964647264","https://openalex.org/W1997654455","https://openalex.org/W1999182858","https://openalex.org/W2007004220","https://openalex.org/W2010405785","https://openalex.org/W2011323454","https://openalex.org/W2023660080","https://openalex.org/W2028443587","https://openalex.org/W2070576324","https://openalex.org/W2109060030","https://openalex.org/W2111311498","https://openalex.org/W2113733099","https://openalex.org/W2126411240","https://openalex.org/W2135435808","https://openalex.org/W2143154260","https://openalex.org/W2549001789"],"related_works":["https://openalex.org/W1968581313","https://openalex.org/W2810663015","https://openalex.org/W2102373670","https://openalex.org/W2809967836","https://openalex.org/W3043254841","https://openalex.org/W2807466365","https://openalex.org/W2084788160","https://openalex.org/W4256435254","https://openalex.org/W2133110153","https://openalex.org/W2408551504"],"abstract_inverted_index":{"Purpose:":[0],"Brachytherapy":[1],"(radioactive":[2],"seed":[3,37,59,129,155,188,214,269],"insertion)":[4],"has":[5,272],"emerged":[6],"as":[7],"one":[8],"of":[9,24,44,78,85,126,163,187,200,236,243],"the":[10,21,42,53,58,91,154,209,234,259,273],"most":[11],"effective":[12],"treatment":[13],"options":[14],"for":[15,111,193],"patients":[16,178],"with":[17,20,141,148,158,179],"prostate":[18,81],"cancer,":[19],"added":[22],"benefit":[23],"a":[25,63,72,97,104,115,171,237,265,277],"convenient":[26],"outpatient":[27],"procedure.":[28],"The":[29,230],"main":[30],"limitation":[31],"in":[32,66,80,206,280],"contemporary":[33],"brachytherapy":[34,82,106],"is":[35,233],"faulty":[36],"placement,":[38],"predominantly":[39],"due":[40,217],"to":[41,55,90,103,133,218,258,275],"presence":[43],"intra-operative":[45,185,213,241],"edema":[46,79,219,244],"(tissue":[47],"expansion).":[48],"Though":[49],"currently":[50,289],"not":[51],"available,":[52],"capability":[54],"intra-operatively":[56],"monitor":[57],"distribution,":[60,270],"can":[61],"make":[62],"significant":[64],"improvement":[65],"cancer":[67],"control.":[68],"We":[69],"present":[70],"such":[71],"system":[73,210,232],"here.":[74],"Methods:":[75],"Intra-operative":[76],"measurement":[77],"requires":[83],"localization":[84],"inserted":[86],"radioactive":[87],"seeds":[88,143],"relative":[89],"prostate.":[92],"Seeds":[93],"were":[94],"reconstructed":[95,153],"using":[96],"typical":[98,251],"non-isocentric":[99,116,252],"C-arm,":[100,253],"and":[101,131,144,166,190,271,286],"exported":[102],"commercial":[105],"delivery":[107],"system.":[108],"Technical":[109],"obstacles":[110],"3D":[112,161],"reconstruction":[113],"on":[114,176,249],"C-arm":[117,120,127,132],"include":[118],"pose-dependent":[119],"calibration;":[121],"distortion":[122],"correction;":[123],"pose":[124],"estimation":[125],"images;":[128],"reconstruction;":[130],"TRUS":[134],"registration.":[135],"Results:":[136],"In":[137,170],"precision-machined":[138],"hard":[139],"phantoms":[140,147],"40-100":[142],"soft":[145],"tissue":[146],"45-87":[149],"seeds,":[150,182],"we":[151,183],"correctly":[152],"implant":[156],"shape":[157],"an":[159,198],"average":[160,199],"precision":[162],"0.35":[164],"mm":[165],"0.24":[167],"mm,":[168,222,225],"respectively.":[169],"DoD":[172],"Phase-1":[173],"clinical":[174,261,281],"trial":[175],"6":[177],"48-82":[180],"planned":[181],"achieved":[184],"monitoring":[186],"distribution":[189],"dosimetry,":[191],"correcting":[192],"dose":[194],"inhomogeneities":[195],"by":[196],"inserting":[197],"4.17":[201],"(1-9)":[202],"additional":[203,256],"seeds.":[204],"Additionally,":[205],"each":[207],"patient,":[208],"automatically":[211],"detected":[212],"migration":[215],"induced":[216],"(mean":[220],"3.84":[221],"STD":[223],"2.13":[224],"Max":[226],"16.19":[227],"mm).":[228],"Conclusions:":[229],"proposed":[231],"first":[235],"kind":[238],"that":[239],"makes":[240],"detection":[242],"(and":[245],"subsequent":[246],"re-optimization)":[247],"possible":[248],"any":[250],"at":[254],"negligible":[255],"cost":[257],"existing":[260],"installation.":[262],"It":[263],"achieves":[264],"significantly":[266],"more":[267],"homogeneous":[268],"potential":[274],"affect":[276],"paradigm":[278],"shift":[279],"practice.":[282],"Large":[283],"scale":[284],"studies":[285],"commercialization":[287],"are":[288],"underway.":[290]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}