{"id":"https://openalex.org/W4362486898","doi":"https://doi.org/10.1117/12.2654329","title":"Multi-modality registration of preoperative MR and intraoperative long-length tomosynthesis using GAN synthesis and 3D-2D registration","display_name":"Multi-modality registration of preoperative MR and intraoperative long-length tomosynthesis using GAN synthesis and 3D-2D registration","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362486898","doi":"https://doi.org/10.1117/12.2654329"},"language":"en","primary_location":{"id":"doi:10.1117/12.2654329","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1117/12.2654329","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018651236","display_name":"Yixuan Huang","orcid":"https://orcid.org/0000-0001-7199-379X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yixuan Huang","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712575","display_name":"Xiaoxuan Zhang","orcid":"https://orcid.org/0000-0003-0365-6833"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxuan Zhang","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015309583","display_name":"Ashley Johnston","orcid":"https://orcid.org/0000-0003-3265-5186"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Johnston","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018714925","display_name":"Craig Jones","orcid":"https://orcid.org/0000-0002-0629-3006"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig K. Jones","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068070550","display_name":"Jeffrey H. Siewerdsen","orcid":"https://orcid.org/0000-0001-6644-1317"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey H. Siewerdsen","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079368329","display_name":"Wojciech Zbijewski","orcid":"https://orcid.org/0000-0001-7593-5394"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wojciech Zbijewski","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081877123","display_name":"Patrick A. Helm","orcid":"https://orcid.org/0009-0009-3734-4951"},"institutions":[{"id":"https://openalex.org/I4210091810","display_name":"Medtronic (United States)","ror":"https://ror.org/00grd1h17","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Helm","raw_affiliation_strings":["Medtronic, Inc. (United States)"],"affiliations":[{"raw_affiliation_string":"Medtronic, Inc. (United States)","institution_ids":["https://openalex.org/I4210091810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061032581","display_name":"Brendan F. Judy","orcid":"https://orcid.org/0000-0002-4981-1408"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendan Judy","raw_affiliation_strings":["Johns Hopkins Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088977223","display_name":"Amanda N. Sacino","orcid":"https://orcid.org/0000-0003-4817-255X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Sacino","raw_affiliation_strings":["Johns Hopkins Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076246161","display_name":"Ali Bydon","orcid":"https://orcid.org/0000-0002-3058-1470"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Bydon","raw_affiliation_strings":["Johns Hopkins Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012706474","display_name":"Timothy F. Witham","orcid":"https://orcid.org/0000-0002-9397-8344"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy F. Witham","raw_affiliation_strings":["Johns Hopkins Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089623752","display_name":"Ali Uneri","orcid":"https://orcid.org/0000-0003-3419-1805"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Uneri","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5018651236"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.1124,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36994484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6718413829803467},{"id":"https://openalex.org/keywords/landmark","display_name":"Landmark","score":0.6632962822914124},{"id":"https://openalex.org/keywords/tomosynthesis","display_name":"Tomosynthesis","score":0.6600116491317749},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.6542240977287292},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.6297750473022461},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6202791333198547},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.5627557039260864},{"id":"https://openalex.org/keywords/projection","display_name":"Projection (relational algebra)","score":0.49232256412506104},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.42302432656288147},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.34356001019477844},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.33335864543914795},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.332340270280838},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.23595786094665527},{"id":"https://openalex.org/keywords/mammography","display_name":"Mammography","score":0.0764026939868927}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6718413829803467},{"id":"https://openalex.org/C2780297707","wikidata":"https://www.wikidata.org/wiki/Q4895393","display_name":"Landmark","level":2,"score":0.6632962822914124},{"id":"https://openalex.org/C147454874","wikidata":"https://www.wikidata.org/wiki/Q7820316","display_name":"Tomosynthesis","level":5,"score":0.6600116491317749},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.6542240977287292},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6297750473022461},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6202791333198547},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.5627557039260864},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.49232256412506104},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.42302432656288147},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.34356001019477844},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.33335864543914795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.332340270280838},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.23595786094665527},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.0764026939868927},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2654329","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1117/12.2654329","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.4699999988079071,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W2037002160","https://openalex.org/W2127961656","https://openalex.org/W2329673985","https://openalex.org/W2569600656","https://openalex.org/W3125875301","https://openalex.org/W3164851425","https://openalex.org/W4200409436","https://openalex.org/W4296605494","https://openalex.org/W4308106769","https://openalex.org/W6729966448"],"related_works":["https://openalex.org/W2056853153","https://openalex.org/W2057559274","https://openalex.org/W2005087563","https://openalex.org/W2378111931","https://openalex.org/W4243161226","https://openalex.org/W2950647290","https://openalex.org/W2620829895","https://openalex.org/W2356918560","https://openalex.org/W1968481813","https://openalex.org/W2392886708"],"abstract_inverted_index":{"A":[0,77],"new":[1],"imaging":[2],"modality":[3],"(viz.,":[4],"Long-Film":[5],"[LF])":[6],"for":[7,59,65,70,206],"acquiring":[8],"long-length":[9],"tomosynthesis":[10],"images":[11,87,103,108,159,187],"of":[12,50,73,139,165,194,221],"the":[13,19,124,151,202,219],"spine":[14],"was":[15,81,92,131,141],"recently":[16],"enabled":[17],"on":[18,94,143,184,212,251],"O-arm\u2122":[20],"system":[21],"and":[22,37,43,52,68,98,123,176,229],"used":[23,82],"in":[24,127,133,146,225],"an":[25],"IRB-approved":[26],"clinical":[27,118,152],"study":[28,119],"at":[29],"our":[30,117],"institution.":[31],"The":[32,55,90,154],"work":[33,200],"presented":[34],"here":[35],"implements":[36],"evaluates":[38],"a":[39,110,134,189],"combined":[40],"image":[41,100,214],"synthesis":[42,155],"registration":[44,49,113,210,224],"approach":[45,56,205,238],"to":[46,83,106,208,239],"solve":[47],"multi-modality":[48],"MR":[51,64,97,181,207,228],"LF":[53,107,186,209,231],"images.":[54,232],"is":[57],"well-suited":[58],"pediatric":[60],"cases":[61,149],"that":[62],"use":[63],"preoperative":[66,227],"diagnosis":[67],"aim":[69],"lower":[71],"levels":[72],"intraoperative":[74,230],"radiation":[75],"exposure.":[76],"patch-based":[78],"conditional":[79],"GAN":[80],"synthesize":[84],"3D":[85,175],"CT":[86,99,158],"from":[88,116,150],"MR.":[89],"network":[91],"trained":[93],"deformably":[95],"co-registered":[96],"pairs.":[101],"Synthesized":[102],"were":[104,120],"registered":[105],"using":[109],"model-based":[111],"3D-2D":[112],"algorithm.":[114],"Images":[115],"manually":[121],"labeled,":[122],"intra-user":[125],"variability":[126],"anatomical":[128,144,178],"landmark":[129],"definition":[130],"measured":[132],"simulation":[135],"study.":[136,153],"Geometric":[137],"accuracy":[138],"registrations":[140],"evaluated":[142],"landmarks":[145,182],"separate":[147],"test":[148],"process":[156],"generated":[157],"with":[160,248],"clear":[161],"bone":[162],"structures.":[163],"Analysis":[164],"manual":[166],"labeling":[167],"revealed":[168],"3.1\u00b12.2":[169],"mm":[170,196],"projection":[171,191],"distance":[172,192],"error":[173,193],"between":[174],"2D":[177],"landmarks.":[179],"Anatomical":[180],"projected":[183],"lateral":[185],"demonstrated":[188,218],"median":[190],"3.6":[195],"after":[197],"registration.":[198],"This":[199],"constitutes":[201],"first":[203],"reported":[204],"based":[211,250],"deep":[213],"synthesis.":[215],"Preliminary":[216],"results":[217],"feasibility":[220],"globally":[222,245],"rigid":[223,243],"aligning":[226],"Work":[233],"currently":[234],"underway":[235],"extends":[236],"this":[237],"vertebra":[240],"level,":[241],"locally":[242],"/":[244],"deformable":[246],"registrations,":[247],"initialization":[249],"automatically":[252],"labeled":[253],"vertebrae":[254],"levels.":[255]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-24T23:09:58.560324","created_date":"2025-10-10T00:00:00"}