{"id":"https://openalex.org/W4362486869","doi":"https://doi.org/10.1117/12.2654104","title":"Self-supervised learning and uncertainty estimation for surgical margin detection","display_name":"Self-supervised learning and uncertainty estimation for surgical margin detection","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362486869","doi":"https://doi.org/10.1117/12.2654104"},"language":"en","primary_location":{"id":"doi:10.1117/12.2654104","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1117/12.2654104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078545925","display_name":"Ayesha Syeda","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ayesha Syeda","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011004341","display_name":"Fahimeh Fooladgar","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fahimeh Fooladgar","raw_affiliation_strings":["Univ. of British Columbia (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002749573","display_name":"Amoon Jamzad","orcid":"https://orcid.org/0000-0002-0828-4365"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amoon Jamzad","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039528391","display_name":"Dilakshan Srikanthan","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dilakshan Srikanthan","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101661555","display_name":"Martin Kaufmann","orcid":"https://orcid.org/0000-0003-0163-2205"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin Kaufmann","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102875140","display_name":"Kevin Ren","orcid":"https://orcid.org/0000-0003-3868-1721"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kevin Ren","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103802569","display_name":"Jay Engel","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jay Engel","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112038381","display_name":"Ross Walker","orcid":"https://orcid.org/0000-0002-3202-2111"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ross Walker","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078370200","display_name":"Shaila J. Merchant","orcid":"https://orcid.org/0000-0002-8133-7988"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shaila Merchant","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103955537","display_name":"Doug McKay","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Doug McKay","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110645","display_name":"Sonal Varma","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sonal Varma","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084753910","display_name":"G\u00e1bor Fichtinger","orcid":"https://orcid.org/0000-0002-6354-262X"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gabor Fichtinger","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108724892","display_name":"John F. Rudan","orcid":null},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John F. Rudan","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040401197","display_name":"Parvin Mousavi","orcid":"https://orcid.org/0000-0002-1630-7379"},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Parvin Mousavi","raw_affiliation_strings":["Queen's Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Univ. (Canada)","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1632,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52125325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"abs/1906.12340","issue":null,"first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9842000007629395,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9842000007629395,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7353020906448364},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6130931377410889},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5731750130653381},{"id":"https://openalex.org/keywords/margin","display_name":"Margin (machine learning)","score":0.5040287375450134},{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.4446735680103302},{"id":"https://openalex.org/keywords/supervised-learning","display_name":"Supervised learning","score":0.42565348744392395},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.22010335326194763}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7353020906448364},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6130931377410889},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5731750130653381},{"id":"https://openalex.org/C774472","wikidata":"https://www.wikidata.org/wiki/Q6760393","display_name":"Margin (machine learning)","level":2,"score":0.5040287375450134},{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.4446735680103302},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.42565348744392395},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.22010335326194763},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2654104","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1117/12.2654104","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2896494478","https://openalex.org/W2898257314","https://openalex.org/W2948194985","https://openalex.org/W2954540134","https://openalex.org/W2965563166","https://openalex.org/W3017517361","https://openalex.org/W3165215466","https://openalex.org/W3180217530","https://openalex.org/W3204337192","https://openalex.org/W4225009109","https://openalex.org/W4285722717","https://openalex.org/W4297963817","https://openalex.org/W6763087592","https://openalex.org/W6765696844","https://openalex.org/W6801913932","https://openalex.org/W6843185664"],"related_works":["https://openalex.org/W4220775285","https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W3046775127","https://openalex.org/W3107602296","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W4364306694","https://openalex.org/W4312192474"],"abstract_inverted_index":{"Up":[0],"to":[1,7,32,77,136,201],"35%":[2],"of":[3,71,85,130,172,189,213,218,246],"breast-conserving":[4],"surgeries":[5],"fail":[6],"resect":[8],"all":[9],"the":[10,18,72,83,127,131,138,194,211,235],"tumors":[11],"completely.":[12],"Ideally,":[13],"machine":[14],"learning":[15,82],"methods":[16],"using":[17,106,126],"iKnife":[19,160],"data,":[20],"which":[21],"uses":[22],"Rapid":[23],"Evaporative":[24],"Ionization":[25],"Mass":[26],"Spectrometry":[27],"(REIMS),":[28],"can":[29,62,74],"be":[30,63,75],"utilized":[31],"predict":[33],"tissue":[34,118],"type":[35],"in":[36,41,97,184,203],"real-time":[37],"during":[38,226],"surgery,":[39],"resulting":[40],"better":[42],"tumor":[43],"resections.":[44],"As":[45],"REIMS":[46],"data":[47,87,170,239,243],"is":[48],"heterogeneous":[49],"and":[50,53,60,68,186,191,206,222,240],"weakly":[51],"labeled,":[52],"datasets":[54],"are":[55],"often":[56],"small,":[57],"model":[58,105,132,163,181,224,236],"performance":[59],"reliability":[61,225],"adversely":[64],"affected.":[65],"Self-supervised":[66],"training":[67],"uncertainty":[69,139,187,204],"estimation":[70],"prediction":[73],"used":[76],"mitigate":[78],"these":[79],"challenges":[80],"by":[81],"signatures":[84],"input":[86],"without":[88,116],"their":[89],"label":[90],"as":[91,93,111],"well":[92],"including":[94],"predictive":[95],"confidence":[96],"output":[98],"reporting.":[99],"We":[100],"first":[101],"design":[102],"an":[103],"autoencoder":[104],"a":[107,112],"reconstruction":[108],"pretext":[109,145],"task":[110,146],"self-supervised":[113],"pretraining":[114],"step":[115],"considering":[117],"type.":[119],"Next,":[120],"we":[121],"construct":[122],"our":[123],"uncertainty-aware":[124],"classifier":[125],"encoder":[128],"part":[129],"with":[133,141],"Masksembles":[134],"layers":[135],"estimate":[137],"associated":[140],"its":[142],"predictions.":[143],"The":[144,162,197],"was":[147,164],"trained":[148,166],"on":[149,167,232,237],"190":[150],"burns":[151,174],"collected":[152,175],"from":[153,156,176],"34":[154],"patients":[155],"Basal":[157],"Cell":[158],"Carcinoma":[159],"data.":[161],"further":[165,233],"breast":[168,248],"cancer":[169],"comprising":[171],"200":[173],"15":[177],"patients.":[178],"Our":[179],"proposed":[180,198],"shows":[182],"improvement":[183],"sensitivity":[185],"metrics":[188],"10%":[190],"15.7%":[192],"over":[193],"baseline,":[195],"respectively.":[196],"strategies":[199],"lead":[200],"improvements":[202],"calibration":[205],"overall":[207],"performance,":[208],"toward":[209],"reducing":[210],"likelihood":[212],"incomplete":[214],"resection,":[215],"supporting":[216],"removal":[217],"minimal":[219],"non-neoplastic":[220],"tissue,":[221],"improved":[223],"surgery.":[227],"Future":[228],"work":[229],"will":[230],"focus":[231],"testing":[234],"intraoperative":[238],"additional":[241],"exvivo":[242],"following":[244],"collection":[245],"more":[247],"samples.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}