{"id":"https://openalex.org/W4322825217","doi":"https://doi.org/10.1117/12.2647894","title":"Need for objective task-based evaluation of AI-based segmentation methods for quantitative PET","display_name":"Need for objective task-based evaluation of AI-based segmentation methods for quantitative PET","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4322825217","doi":"https://doi.org/10.1117/12.2647894","pmid":"https://pubmed.ncbi.nlm.nih.gov/36911274"},"language":"en","primary_location":{"id":"doi:10.1117/12.2647894","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2647894","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2023: Image Perception, Observer Performance, and Technology Assessment","raw_type":"proceedings-article"},"type":"preprint","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2303.00640","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066886328","display_name":"Ziping Liu","orcid":"https://orcid.org/0000-0001-8107-6522"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ziping Liu","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","Washington Univ. in St. Louis (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington Univ. in St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022454617","display_name":"Joyce Mhlanga","orcid":"https://orcid.org/0000-0002-6136-265X"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce C. Mhlanga","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA","Washington Univ. School of Medicine, St. Louis (United States)"],"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]},{"raw_affiliation_string":"Washington Univ. School of Medicine, St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049988109","display_name":"Barry A. Siegel","orcid":"https://orcid.org/0000-0001-6246-5792"},"institutions":[{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry A. Siegel","raw_affiliation_strings":["Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA","Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA","Washington Univ. School of Medicine, St. Louis (United States)","Washington Univ. in St. Louis (United States)"],"affiliations":[{"raw_affiliation_string":"Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]},{"raw_affiliation_string":"Washington Univ. School of Medicine, St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington Univ. in St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081456414","display_name":"Abhinav K. Jha","orcid":"https://orcid.org/0000-0002-4795-4878"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]},{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhinav K. Jha","raw_affiliation_strings":["Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA","Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA","Washington Univ. School of Medicine, St. Louis (United States)","Washington Univ. in St. Louis (United States)"],"affiliations":[{"raw_affiliation_string":"Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]},{"raw_affiliation_string":"Washington Univ. School of Medicine, St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Washington Univ. in St. Louis (United States)","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066886328"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":1.5756,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.8245604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"12467","issue":null,"first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.8244983553886414},{"id":"https://openalex.org/keywords/dice","display_name":"Dice","score":0.7980011105537415},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.685117244720459},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6418786644935608},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.5346184372901917},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.534507155418396},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4389329254627228},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3604483902454376},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34256961941719055},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.2008700966835022},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13940778374671936},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11065298318862915},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10511556267738342}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8244983553886414},{"id":"https://openalex.org/C22029948","wikidata":"https://www.wikidata.org/wiki/Q45089","display_name":"Dice","level":2,"score":0.7980011105537415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.685117244720459},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6418786644935608},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5346184372901917},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.534507155418396},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4389329254627228},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3604483902454376},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34256961941719055},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2008700966835022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13940778374671936},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11065298318862915},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10511556267738342},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1117/12.2647894","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2647894","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2023: Image Perception, Observer Performance, and Technology Assessment","raw_type":"proceedings-article"},{"id":"pmid:36911274","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36911274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ArXiv","raw_type":null},{"id":"pmid:37990707","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37990707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:arXiv.org:2303.00640","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2303.00640","pdf_url":"https://arxiv.org/pdf/2303.00640","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10659582","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10659582","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10659582/pdf/nihms-1900248.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10002799","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10002799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ArXiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2303.00640","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2303.00640","pdf_url":"https://arxiv.org/pdf/2303.00640","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6200000047683716}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4322825217.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1967362871","https://openalex.org/W1970991589","https://openalex.org/W2005901685","https://openalex.org/W2027350525","https://openalex.org/W2083927153","https://openalex.org/W2107224150","https://openalex.org/W2107955465","https://openalex.org/W2123507044","https://openalex.org/W2153530160","https://openalex.org/W2160850888","https://openalex.org/W2292929658","https://openalex.org/W2302322399","https://openalex.org/W2520164769","https://openalex.org/W2546764771","https://openalex.org/W2593435087","https://openalex.org/W2766404443","https://openalex.org/W2797624406","https://openalex.org/W2902972155","https://openalex.org/W2922006629","https://openalex.org/W3015168408","https://openalex.org/W3033463765","https://openalex.org/W3131794481","https://openalex.org/W3157745967","https://openalex.org/W3161070379","https://openalex.org/W3179608547","https://openalex.org/W3198929365","https://openalex.org/W3199152014","https://openalex.org/W4221080520","https://openalex.org/W4254612313","https://openalex.org/W4281795046","https://openalex.org/W4282922560","https://openalex.org/W4323546622"],"related_works":["https://openalex.org/W3104750253","https://openalex.org/W3021239166","https://openalex.org/W2586273397","https://openalex.org/W2390936256","https://openalex.org/W2016385589","https://openalex.org/W2009559548","https://openalex.org/W2483429559","https://openalex.org/W2890643743","https://openalex.org/W4366341510","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Artificial":[0],"intelligence":[1],"(AI)-based":[2],"methods":[3,33,85,198],"are":[4,34,175],"showing":[5],"substantial":[6],"promise":[7],"in":[8,159],"segmenting":[9],"oncologic":[10],"positron":[11],"emission":[12],"tomography":[13],"(PET)":[14],"images.":[15],"For":[16],"clinical":[17,97,137],"translation":[18],"of":[19,58,99,110,116,145,183,195],"these":[20,32],"methods,":[21],"assessing":[22],"their":[23],"performance":[24],"on":[25,95],"clinically":[26],"relevant":[27],"tasks":[28,98],"is":[29,52],"important.":[30],"However,":[31],"typically":[35],"evaluated":[36,142],"using":[37,86,152,167,179],"metrics":[38],"that":[39,60,165,174],"may":[40],"not":[41],"correlate":[42],"with":[43,118,131,177],"the":[44,53,62,66,96,132,157,180,189],"task":[45],"performance.":[46],"One":[47],"such":[48],"widely":[49],"used":[50,148],"metric":[51],"Dice":[54,87,154,168],"score,":[55],"a":[56,70,90,128,146],"figure":[57,182],"merit":[59],"measures":[61],"spatial":[63],"overlap":[64],"between":[65],"estimated":[67],"segmentation":[68,84,150,197],"and":[69,105,156],"reference":[71],"standard":[72],"(e.g.,":[73],"manual":[74],"segmentation).":[75],"In":[76],"this":[77],"work,":[78],"we":[79,141],"investigated":[80],"whether":[81],"evaluating":[82],"AI-based":[83,149,196],"scores":[88,155,169],"yields":[89],"similar":[91],"interpretation":[92],"as":[93],"evaluation":[94,166,178,194],"quantifying":[100,160],"metabolic":[101],"tumor":[102,112],"volume":[103],"(MTV)":[104],"total":[106],"lesion":[107],"glycolysis":[108],"(TLG)":[109],"primary":[111],"from":[113],"PET":[114],"images":[115],"patients":[117],"non-small":[119],"cell":[120],"lung":[121],"cancer.":[122],"The":[123],"investigation":[124],"was":[125],"conducted":[126],"via":[127],"retrospective":[129],"analysis":[130],"ECOG-ACRIN":[133],"6668/RTOG":[134],"0235":[135],"multi-center":[136],"trial":[138],"data.":[139],"Specifically,":[140],"different":[143],"structures":[144],"commonly":[147],"method":[151],"both":[153],"accuracy":[158],"MTV/TLG.":[161],"Our":[162],"results":[163],"show":[164],"can":[170],"lead":[171],"to":[172],"findings":[173],"inconsistent":[176],"task-based":[181,193],"merit.":[184],"Thus,":[185],"our":[186],"study":[187],"motivates":[188],"need":[190],"for":[191,199],"objective":[192],"quantitative":[200],"PET.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-04-18T07:56:08.524223","created_date":"2023-03-03T00:00:00"}