{"id":"https://openalex.org/W4212849458","doi":"https://doi.org/10.1117/12.2613599","title":"Identifying radiomic features associated with disease activity, patient outcomes, and serum phenotypes in pediatric Crohn's disease via MRI","display_name":"Identifying radiomic features associated with disease activity, patient outcomes, and serum phenotypes in pediatric Crohn's disease via MRI","publication_year":2022,"publication_date":"2022-02-18","ids":{"openalex":"https://openalex.org/W4212849458","doi":"https://doi.org/10.1117/12.2613599"},"language":"en","primary_location":{"id":"doi:10.1117/12.2613599","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2613599","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067908938","display_name":"Prathyush Chirra","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prathyush Chirra","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034660629","display_name":"Avani Muchhala","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avani Muchhala","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114034094","display_name":"K. Amann","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelin Amann","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038967402","display_name":"Kaajal Krishnan","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaajal Krishnan","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000987623","display_name":"Jacob A. Kurowski","orcid":"https://orcid.org/0000-0002-4333-8998"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Kurowski","raw_affiliation_strings":["Cleveland Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic (United States)","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016940872","display_name":"Satish E. Viswanath","orcid":"https://orcid.org/0000-0003-4550-8337"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satish E. Viswanath","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3029,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45807077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"67","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12578","display_name":"Diagnosis and treatment of tuberculosis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.7781829833984375},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6282753348350525},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6066980361938477},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"Clinical phenotype","score":0.6009798645973206},{"id":"https://openalex.org/keywords/crohns-disease","display_name":"Crohn's disease","score":0.5611969828605652},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.41098690032958984},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3966262936592102},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3860677182674408},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1352601945400238},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.05755317211151123},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.05123808979988098}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7781829833984375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6282753348350525},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6066980361938477},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.6009798645973206},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5611969828605652},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.41098690032958984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3966262936592102},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3860677182674408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1352601945400238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05755317211151123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05123808979988098}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2613599","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2613599","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6000000238418579}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W656395023","https://openalex.org/W2034008046","https://openalex.org/W2074100287","https://openalex.org/W2128739912","https://openalex.org/W2258323245","https://openalex.org/W2340118087","https://openalex.org/W2342042294","https://openalex.org/W2413403309","https://openalex.org/W2511742612","https://openalex.org/W2560860283","https://openalex.org/W2944325924","https://openalex.org/W3027844206","https://openalex.org/W3112439661","https://openalex.org/W3132674558","https://openalex.org/W4214920103","https://openalex.org/W4243588327","https://openalex.org/W6725662677"],"related_works":["https://openalex.org/W3164771895","https://openalex.org/W2604464132","https://openalex.org/W2161088626","https://openalex.org/W3029893540","https://openalex.org/W2314682585","https://openalex.org/W2313584493","https://openalex.org/W2135667114","https://openalex.org/W2110968082","https://openalex.org/W3122747281","https://openalex.org/W2070809590"],"abstract_inverted_index":{"Pediatric":[0],"Crohn\u2019s":[1],"disease":[2,9,69,121,151],"(pCD)":[3],"is":[4,16,34,43],"a":[5,17,136,144],"chronic":[6],"relapsing-remitting":[7],"inflammatory":[8],"of":[10,56,82,170,182],"the":[11,104,132,166,222],"gastrointestinal":[12],"tract,":[13],"where":[14,103],"there":[15],"significant":[18],"need":[19],"for":[20,149],"non-invasive":[21],"comprehensive":[22],"markers":[23],"to":[24,37,60,200,224],"accurately":[25],"target":[26],"clinical":[27],"interventions.":[28,241],"While":[29],"Magnetic":[30],"Resonance":[31],"Enterography":[32],"(MRE)":[33],"often":[35],"used":[36],"localize":[38],"pCD":[39,52,86,101,206,227],"in":[40,46,74,172,184,189],"vivo,":[41],"it":[42],"still":[44],"limited":[45],"predicting":[47],"treatment":[48,72,125],"response":[49],"and":[50,71,100,114,141,153,179,194,214,229],"capturing":[51],"phenotypes.":[53],"The":[54],"goal":[55],"this":[57],"study":[58],"was":[59,106],"identify":[61],"radiomic":[62,196],"features":[63,128,197,218],"on":[64,135],"baseline":[65],"MRE":[66,89,140],"associated":[67],"with":[68,84,204],"activity":[70],"outcomes":[73,155],"pCD,":[75],"as":[76,78],"well":[77],"investigate":[79],"potential":[80],"associations":[81],"radiomics":[83],"serum-based":[85],"subtypes.":[87],"Baseline":[88],"scans":[90],"were":[91,129,198],"acquired":[92],"from":[93,131,139,176,187],"45":[94],"pediatric":[95],"subjects":[96,178],"(including":[97],"healthy":[98,177],"controls":[99],"patients)":[102],"latter":[105],"further":[107],"sub-grouped":[108],"into":[109],"responders":[110],"(stable":[111],"after":[112,124],"treatment)":[113],"non-responders":[115],"(required":[116],"surgery":[117],"or":[118],"had":[119],"active":[120],"2+":[122],"years":[123],"initiation).":[126],"Radiomic":[127,217],"extracted":[130],"terminal":[133],"ileum":[134],"per-voxel":[137],"basis":[138],"evaluated":[142],"via":[143,239],"multi-stage":[145],"feature":[146],"selection":[147],"scheme":[148],"identifying":[150],"presence":[152],"patient":[154,231],"separately.":[156],"A":[157],"Random":[158],"Forest":[159],"(RF)":[160],"classifier":[161],"achieved":[162],"an":[163,180],"area":[164],"under":[165],"ROC":[167],"curve":[168],"(AUC)":[169],"0.83":[171],"distinguishing":[173,185],"diseased":[174],"patients":[175],"AUC":[181],"0.85":[183],"nonresponders":[186],"responders;":[188],"leave-one-out":[190],"cross-validation.":[191],"Top-ranked":[192],"Gabor":[193],"Laws":[195],"found":[199],"be":[201,236],"significantly":[202],"correlated":[203],"serum":[205],"phenotypes":[207,228],"including":[208],"anemia,":[209],"inflammation":[210],"risk,":[211],"vitamin":[212],"deficiency,":[213],"immune":[215],"activity.":[216],"may":[219],"therefore":[220],"offer":[221],"ability":[223],"better":[225],"characterize":[226],"predict":[230],"outcomes,":[232],"which":[233],"could":[234],"then":[235],"effectively":[237],"treated":[238],"targeted":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
