{"id":"https://openalex.org/W4220820834","doi":"https://doi.org/10.1117/12.2613277","title":"Human brain extraction with deep learning","display_name":"Human brain extraction with deep learning","publication_year":2022,"publication_date":"2022-03-31","ids":{"openalex":"https://openalex.org/W4220820834","doi":"https://doi.org/10.1117/12.2613277"},"language":"en","primary_location":{"id":"doi:10.1117/12.2613277","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2613277","pdf_url":null,"source":{"id":"https://openalex.org/S4363607561","display_name":"Medical Imaging 2022: Image Processing","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Image Processing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100348717","display_name":"Hao Li","orcid":"https://orcid.org/0009-0001-0673-7711"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hao Li","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080352878","display_name":"Qibang Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qibang Zhu","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100936577","display_name":"Dewei Hu","orcid":"https://orcid.org/0009-0005-5823-1498"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dewei Hu","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013197526","display_name":"Manasvi R. Gunnala","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manasvi R. Gunnala","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084167572","display_name":"Hans J. Johnson","orcid":"https://orcid.org/0000-0001-9513-2660"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans J. Johnson","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070933644","display_name":"Omar Sherbini","orcid":"https://orcid.org/0000-0001-6581-250X"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Sherbini","raw_affiliation_strings":["The Children's Hospital of Philadelphia (United States)"],"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia (United States)","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065715672","display_name":"Francesco Gavazzi","orcid":"https://orcid.org/0000-0002-4908-8395"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesco Gavazzi","raw_affiliation_strings":["The Children's Hospital of Philadelphia (United States)"],"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia (United States)","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007480499","display_name":"Russell D\u2019Aiello","orcid":null},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell D\u2019Aiello","raw_affiliation_strings":["The Children's Hospital of Philadelphia (United States)"],"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia (United States)","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013089390","display_name":"Adeline Vanderver","orcid":"https://orcid.org/0000-0002-6290-6751"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adeline Vanderver","raw_affiliation_strings":["The Children's Hospital of Philadelphia (United States)"],"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia (United States)","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040078713","display_name":"Jeffrey D. Long","orcid":"https://orcid.org/0000-0001-7181-9652"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Long","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048054839","display_name":"Jane S. Paulsen","orcid":"https://orcid.org/0000-0002-0983-228X"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane S. Paulsen","raw_affiliation_strings":["Univ. of Wisconsin-Madison (United States)"],"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin-Madison (United States)","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020532873","display_name":"\u0130pek O\u011fuz","orcid":"https://orcid.org/0000-0002-1403-2420"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ipek Oguz","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5100348717"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.1799,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.47533153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"11596","issue":null,"first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6792593002319336},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5256344676017761},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5159255266189575},{"id":"https://openalex.org/keywords/extraction","display_name":"Extraction (chemistry)","score":0.5134854912757874},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.4297696352005005},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.24707084894180298},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.16574707627296448},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.07059234380722046},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.0665159821510315}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6792593002319336},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5256344676017761},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5159255266189575},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5134854912757874},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4297696352005005},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24707084894180298},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16574707627296448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07059234380722046},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0665159821510315}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2613277","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2613277","pdf_url":null,"source":{"id":"https://openalex.org/S4363607561","display_name":"Medical Imaging 2022: Image Processing","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Image Processing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1488525638","https://openalex.org/W2004904115","https://openalex.org/W2042113568","https://openalex.org/W2145661921","https://openalex.org/W2148407863","https://openalex.org/W2151050383","https://openalex.org/W2194775991","https://openalex.org/W2284198383","https://openalex.org/W2464708700","https://openalex.org/W2962914239","https://openalex.org/W2967194415","https://openalex.org/W3003864320","https://openalex.org/W4248133207","https://openalex.org/W4253866260","https://openalex.org/W4254647276","https://openalex.org/W4256188663","https://openalex.org/W6681934880","https://openalex.org/W6718752587","https://openalex.org/W6766419015","https://openalex.org/W6768387861","https://openalex.org/W6790688334","https://openalex.org/W6790739011"],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W3215138031","https://openalex.org/W3009238340","https://openalex.org/W4321369474","https://openalex.org/W4360585206","https://openalex.org/W4285208911","https://openalex.org/W3082895349","https://openalex.org/W4213079790","https://openalex.org/W2248239756","https://openalex.org/W4323565446"],"abstract_inverted_index":{"Brain":[0],"extraction,":[1],"also":[2,25],"known":[3],"as":[4,27,64],"skull":[5],"stripping,":[6],"from":[7],"magnetic":[8],"resonance":[9],"images":[10],"(MRIs)":[11],"is":[12,24],"an":[13,76],"essential":[14],"preprocessing":[15],"step":[16],"for":[17,31,48,81,158],"many":[18,38],"medical":[19],"image":[20],"analysis":[21],"tasks":[22],"and":[23,94,108,139,156],"useful":[26],"a":[28],"stand-alone":[29],"task":[30],"estimating":[32],"the":[33,106,109,127,131],"total":[34],"brain":[35,82],"volume.":[36],"Currently,":[37],"proposed":[39],"methods":[40,53],"have":[41],"excellent":[42],"performance":[43],"on":[44,84,105,144],"T1-weighted":[45,85],"images,":[46],"especially":[47],"healthy":[49,89],"adults.":[50],"However,":[51],"such":[52,63],"do":[54],"not":[55],"always":[56],"generalize":[57],"well":[58],"to":[59,120],"more":[60],"challenging":[61],"datasets":[62,115],"pediatric,":[65],"severely":[66],"pathological,":[67],"or":[68],"heterogeneous":[69,159],"data.":[70],"In":[71],"this":[72],"paper,":[73],"we":[74],"propose":[75],"automatic":[77],"deep":[78],"learning":[79],"framework":[80],"extraction":[83],"MRIs":[86],"of":[87],"adult":[88],"controls,":[90],"Huntington\u2019s":[91],"disease":[92],"patients":[93],"pediatric":[95],"Aicardi":[96],"Gouti`eres":[97],"Syndrome":[98],"(AGS)":[99],"patients.":[100],"We":[101],"examine":[102],"our":[103,124,151],"method":[104,125,152],"PREDICT-HD":[107],"AGS":[110],"datasets,":[111],"which":[112],"are":[113],"multi-site":[114],"with":[116,130],"different":[117],"protocols/scanners.":[118],"Compared":[119],"current":[121],"state-of-the-art":[122],"methods,":[123],"produced":[126],"best":[128],"segmentations":[129],"highest":[132],"Dice":[133],"score,":[134],"lowest":[135,140],"average":[136],"surface":[137],"distance":[138,143],"95-percent":[141],"Hausdorff":[142],"both":[145],"datasets.":[146,162],"These":[147],"results":[148],"indicate":[149],"that":[150],"has":[153],"better":[154],"accuracy":[155],"generalizability":[157],"T1-w":[160],"MRI":[161]},"counts_by_year":[{"year":2023,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}