{"id":"https://openalex.org/W4221100936","doi":"https://doi.org/10.1117/12.2613060","title":"Automated CT segmentation for rapid assessment of anatomical variations in head-and-neck radiation therapy","display_name":"Automated CT segmentation for rapid assessment of anatomical variations in head-and-neck radiation therapy","publication_year":2022,"publication_date":"2022-04-01","ids":{"openalex":"https://openalex.org/W4221100936","doi":"https://doi.org/10.1117/12.2613060"},"language":"en","primary_location":{"id":"doi:10.1117/12.2613060","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2613060","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026661364","display_name":"Xianjin Dai","orcid":"https://orcid.org/0000-0002-4629-1996"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianjin Dai","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011903902","display_name":"Yang Lei","orcid":"https://orcid.org/0000-0002-3572-0345"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Lei","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049656223","display_name":"Tonghe Wang","orcid":"https://orcid.org/0000-0001-9021-1204"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tonghe Wang","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037131488","display_name":"Zhen Tian","orcid":"https://orcid.org/0000-0003-0945-8168"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Tian","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043052005","display_name":"Jun Zhou","orcid":"https://orcid.org/0000-0002-6078-9424"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhou","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086616055","display_name":"Mark W. McDonald","orcid":"https://orcid.org/0000-0003-3021-9356"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark McDonald","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067547603","display_name":"David S. Yu","orcid":"https://orcid.org/0000-0002-2781-5379"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Yu","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006181985","display_name":"Beth Ghavidel","orcid":"https://orcid.org/0009-0003-8590-5246"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth B. Ghavidel","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002507883","display_name":"Jeffrey D. Bradley","orcid":"https://orcid.org/0000-0003-3047-3151"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Bradley","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365649","display_name":"Tian Liu","orcid":"https://orcid.org/0000-0002-2906-5110"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Liu","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100619090","display_name":"Xiaofeng Yang","orcid":"https://orcid.org/0000-0001-9023-5855"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Yang","raw_affiliation_strings":["Winship Cancer Institute, Emory Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":2.7487,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.85993691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"70","issue":null,"first_page":"37","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck","display_name":"Head and neck","score":0.6922105550765991},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.58579021692276},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.5716103315353394},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5028981566429138},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4663611650466919},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.40827977657318115},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39411646127700806},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.35636723041534424},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.329155832529068},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3204195499420166},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.0690712034702301}],"concepts":[{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.6922105550765991},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.58579021692276},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5716103315353394},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5028981566429138},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4663611650466919},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40827977657318115},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39411646127700806},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.35636723041534424},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.329155832529068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3204195499420166},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0690712034702301}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2613060","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2613060","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","score":0.4000000059604645,"display_name":"Decent work and economic growth"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1492136537","https://openalex.org/W1999189079","https://openalex.org/W2028129509","https://openalex.org/W2035306925","https://openalex.org/W2072163929","https://openalex.org/W2084851290","https://openalex.org/W2137013440","https://openalex.org/W2295107390","https://openalex.org/W2766997060","https://openalex.org/W2925359305","https://openalex.org/W3120274550","https://openalex.org/W3176482836","https://openalex.org/W4233931939","https://openalex.org/W6629471147","https://openalex.org/W6633658626","https://openalex.org/W6638444622"],"related_works":["https://openalex.org/W2355955825","https://openalex.org/W2056534599","https://openalex.org/W4206801305","https://openalex.org/W2382476776","https://openalex.org/W2383628288","https://openalex.org/W3210497498","https://openalex.org/W2066639416","https://openalex.org/W4281252931","https://openalex.org/W177678164","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Typical":[0],"radiation":[1,276],"therapy":[2],"for":[3,8,30,93,243,258,268],"head-and-neck":[4],"cancer":[5,35],"patients":[6],"lasts":[7],"more":[9],"than":[10],"a":[11,68,89,192],"month.":[12],"Anatomical":[13],"variations":[14,273],"often":[15],"occur":[16],"along":[17,239],"the":[18,23,39,60,65,108,151,163,172,183,188,240,245,250,271],"treatment":[19,61,241],"course":[20,242],"due":[21],"to":[22,53,87,105,143,161],"tumor":[24],"shrinkage":[25],"and":[26,32,58,71,101,116,130,137,149,169,216,235,252],"weight":[27],"loss,":[28],"particularly":[29],"head":[31,100,178],"neck":[33,102],"(HN)":[34,103],"patients.":[36],"To":[37],"maintain":[38],"accuracy":[40],"of":[41,76,96,120,154,174,232,254],"radiotherapy":[42],"beam":[43],"delivery,":[44],"weekly":[45,202],"quality":[46],"assurance":[47],"(QA)":[48],"CT":[49,99,148,203],"is":[50,67,141,159],"sometime":[51],"acquired":[52],"monitor":[54],"patients\u2019":[55,197],"anatomical":[56,109,272],"changes,":[57],"re-plan":[59,66,77],"if":[62],"needed.":[63],"However,":[64],"labor":[69],"intensive":[70],"time-consuming":[72],"process,":[73],"thus,":[74],"decisions":[75],"are":[78],"always":[79],"made":[80],"cautiously.":[81],"In":[82],"this":[83],"study,":[84],"we":[85],"aim":[86],"develop":[88],"deep":[90],"learning-based":[91],"method":[92,257],"automated":[94],"segmentation":[95,223,260],"multi-organ":[97],"from":[98,147,182,261],"images":[104],"rapidly":[106],"evaluate":[107,270],"variations.":[110],"Our":[111],"proposed":[112,256],"method,":[113],"named":[114],"detecting":[115],"boosting":[117],"network,":[118],"consists":[119],"one":[121,125],"pre-trained":[122],"fully":[123],"convolutional":[124],"stage":[126],"objection":[127],"detector":[128],"(FCOS)":[129],"two":[131],"learnable":[132],"subnetworks,":[133],"i.e.,":[134],"hierarchical":[135],"block":[136,158],"mask":[138],"head.":[139],"FCOS":[140],"used":[142,160,267],"extract":[144],"informative":[145],"features":[146],"locate":[150],"volume-of-interest":[152],"(VOIs)":[153],"multiple":[155,201],"organs.":[156,246],"Hierarchical":[157],"enhance":[162],"feature":[164,185],"contrast":[165],"around":[166],"organ":[167,175,181],"boundary":[168],"thus":[170],"improve":[171],"ability":[173],"classification.":[176],"Mask":[177],"then":[179],"segment":[180],"refined":[184],"map":[186],"within":[187],"VOIs.":[189],"We":[190],"conducted":[191],"five-fold":[193],"cross-validation":[194],"on":[195],"35":[196],"cases":[198],"who":[199],"have":[200],"scans":[204],"(over":[205],"100":[206],"QACTs)":[207],"during":[208],"their":[209],"radiotherapy.":[210],"The":[211,225],"11":[212],"organs":[213],"were":[214,237],"segmented":[215],"compared":[217],"with":[218],"manual":[219],"contours":[220],"using":[221],"several":[222],"measurements.":[224],"mean":[226],"Dice":[227],"similarity":[228],"coefficient":[229],"(DSC)":[230],"values":[231],"0.82,":[233,234],"0.81":[236],"achieved":[238],"all":[244],"These":[247],"results":[248],"demonstrate":[249],"feasibility":[251],"efficacy":[253],"our":[255],"multi-OAR":[259],"HN":[262,275],"CT,":[263],"which":[264],"can":[265],"be":[266],"rapid":[269],"in":[274],"therapy.":[277]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}