{"id":"https://openalex.org/W4226396484","doi":"https://doi.org/10.1117/12.2612892","title":"Automatic generation of the ground truth for tumor budding using H&amp;E stained slides","display_name":"Automatic generation of the ground truth for tumor budding using H&amp;E stained slides","publication_year":2022,"publication_date":"2022-04-04","ids":{"openalex":"https://openalex.org/W4226396484","doi":"https://doi.org/10.1117/12.2612892"},"language":"en","primary_location":{"id":"doi:10.1117/12.2612892","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2612892","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Digital and Computational Pathology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045373968","display_name":"Thomas E. Tavolara","orcid":"https://orcid.org/0000-0001-6455-3120"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Tavolara","raw_affiliation_strings":["Wake Forest School of Medicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest School of Medicine (United States)","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067376795","display_name":"Arijit Dutta","orcid":"https://orcid.org/0000-0001-8517-0073"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arijit Dutta","raw_affiliation_strings":["Wake Forest School of Medicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest School of Medicine (United States)","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036716632","display_name":"Martin V. Burks","orcid":null},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin V. Burks","raw_affiliation_strings":["Wake Forest Baptist Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Baptist Medical Ctr. (United States)","institution_ids":["https://openalex.org/I1282516798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344481","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0002-7663-278X"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["The Ohio State Univ. Wexner Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State Univ. Wexner Medical Ctr. (United States)","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061124226","display_name":"Wendy L. Frankel","orcid":"https://orcid.org/0000-0003-1658-1009"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Frankel","raw_affiliation_strings":["The Ohio State Univ. Wexner Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State Univ. Wexner Medical Ctr. (United States)","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077316017","display_name":"Metin N. G\u00fcrcan","orcid":"https://orcid.org/0000-0002-2421-8229"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Metin N. Gurcan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034159054","display_name":"Muhammad Khalid Khan Niazi","orcid":"https://orcid.org/0000-0002-1278-7512"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Khalid Khan Niazi","raw_affiliation_strings":["Wake Forest School of Medicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest School of Medicine (United States)","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1387,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52480907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"72","issue":null,"first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokeratin","display_name":"Cytokeratin","score":0.863956868648529},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.5038651823997498},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.48073387145996094},{"id":"https://openalex.org/keywords/tumor-budding","display_name":"Tumor budding","score":0.4390139579772949},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4055075943470001},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.26270806789398193},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25170719623565674},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.13699519634246826},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08503380417823792}],"concepts":[{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.863956868648529},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5038651823997498},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.48073387145996094},{"id":"https://openalex.org/C2779188454","wikidata":"https://www.wikidata.org/wiki/Q16948689","display_name":"Tumor budding","level":5,"score":0.4390139579772949},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4055075943470001},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26270806789398193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25170719623565674},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.13699519634246826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08503380417823792},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2612892","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2612892","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Digital and Computational Pathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1578387260","https://openalex.org/W1998493994","https://openalex.org/W2090056811","https://openalex.org/W2106021780","https://openalex.org/W2239955782","https://openalex.org/W2620163964","https://openalex.org/W2630837129","https://openalex.org/W2847909318","https://openalex.org/W2888793802","https://openalex.org/W2896494478","https://openalex.org/W2922475342","https://openalex.org/W2923334665","https://openalex.org/W2974825848","https://openalex.org/W2994908874","https://openalex.org/W2995811766","https://openalex.org/W3094502228","https://openalex.org/W3138516171","https://openalex.org/W4230483857","https://openalex.org/W4245275196","https://openalex.org/W4251339743","https://openalex.org/W4385245566","https://openalex.org/W6633658626","https://openalex.org/W6739696289","https://openalex.org/W6739901393","https://openalex.org/W6784333009","https://openalex.org/W6792155083"],"related_works":["https://openalex.org/W1998493994","https://openalex.org/W2847909318","https://openalex.org/W2078728072","https://openalex.org/W2412797760","https://openalex.org/W2061468067","https://openalex.org/W2394675956","https://openalex.org/W2032117488","https://openalex.org/W4390014046","https://openalex.org/W3087666317","https://openalex.org/W3015199007"],"abstract_inverted_index":{"Tumor":[0],"budding":[1,86],"(TB)":[2],"is":[3,32,51],"defined":[4],"as":[5,21],"a":[6,22,158,172],"cluster":[7],"of":[8,65,98,187,201,239],"one":[9],"to":[10,68,75,80,140,166,179,189,216,230,242],"four":[11],"tumor":[12,16,57,85,118,134,142,151,163],"cells":[13],"at":[14],"the":[15,63,162,237],"invasive":[17,164],"front.":[18],"Though":[19],"promising":[20],"prognostic":[23],"factor":[24],"for":[25,84,117,133,150,157,236,246],"colorectal":[26],"cancer,":[27],"its":[28],"routine":[29,42,88],"clinical":[30],"use":[31],"hampered":[33],"by":[34],"high":[35],"inter-":[36],"and":[37,54,103,115,120,131,147,152,199,206,210,223],"intra-":[38],"observer":[39],"disagreement":[40],"on":[41,195,212,218,228],"H&E":[43,89,104,181,196,213,229],"staining.":[44,94],"Pan-cytokeratin":[45],"immunohistochemical":[46],"staining":[47],"increases":[48],"agreement":[49],"but":[50],"costly,":[52],"nonroutine,":[53],"may":[55],"yield":[56],"bud":[58],"false":[59],"positives.":[60],"This":[61,155],"makes":[62],"development":[64],"automatic":[66],"algorithms":[67],"identify":[69,167],"TB":[70,247],"difficult.":[71],"Therefore,":[72],"we":[73,170],"sought":[74],"develop":[76],"an":[77],"automated":[78],"method":[79,174,241],"generate":[81,243],"ground":[82,244],"truth":[83,245],"from":[87,92,107,125],"that":[90],"benefits":[91],"pan-cytokeratin":[93,102,177,188],"Our":[95],"database":[96],"consisted":[97],"1)":[99],"120":[100],"adjacent":[101,123,180],"tissue":[105],"sections":[106,124],"which":[108,126,175,220],"648":[109],"manually-registered":[110],"high-power":[111],"fields":[112,128],"were":[113,129,138,208],"extracted":[114,130],"annotated":[116,132],"regions":[119,186,194],"2)":[121],"ten":[122],"109":[127],"buds.":[135],"Swin":[136],"transformers":[137],"applied":[139],"segment":[141],"regions,":[143],"resulting":[144],"in":[145],"95%":[146],"99%":[148],"accuracy":[149],"non-tumor":[153],"regions.":[154],"allowed":[156],"narrow":[159],"margin":[160],"outside":[161],"front":[165],"TB.":[168],"Next,":[169],"developed":[171],"novel":[173],"registers":[176],"images":[178],"images,":[182],"transfers":[183],"automatically-identified":[184],"positive":[185,193],"H&E,":[190,219],"then":[191],"filters":[192],"using":[197,248],"size":[198],"number":[200],"nuclei.":[202],"The":[203],"average":[204],"precision":[205],"recall":[207],"0.3856":[209],"0.3254":[211],"when":[214,225],"compared":[215],"pathologists":[217,227],"exceeded":[221],"0.3470":[222],"0.1932":[224],"comparing":[226],"pan-cytokeratin.":[231],"Results":[232],"provide":[233],"preliminary":[234],"evidence":[235],"feasibility":[238],"our":[240],"H&E.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
