{"id":"https://openalex.org/W4220846548","doi":"https://doi.org/10.1117/12.2611809","title":"Brain multi-parametric MRI tumor subregion segmentation via hierarchical substructural activation network","display_name":"Brain multi-parametric MRI tumor subregion segmentation via hierarchical substructural activation network","publication_year":2022,"publication_date":"2022-03-30","ids":{"openalex":"https://openalex.org/W4220846548","doi":"https://doi.org/10.1117/12.2611809"},"language":"en","primary_location":{"id":"doi:10.1117/12.2611809","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2611809","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011903902","display_name":"Yang Lei","orcid":"https://orcid.org/0000-0002-3572-0345"},"institutions":[{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Lei","raw_affiliation_strings":["Emory Univ. (United States)","Winship Cancer Institute (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046162873","display_name":"Shadab Momin","orcid":"https://orcid.org/0000-0002-1640-3643"},"institutions":[{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shadab Momin","raw_affiliation_strings":["Winship Cancer Institute (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371740","display_name":"Zhen Tian","orcid":"https://orcid.org/0000-0002-7026-7582"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Tian","raw_affiliation_strings":["Winship Cancer Institute (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108367355","display_name":"Justin Roper","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Roper","raw_affiliation_strings":["Emory Univ. (United States)","Winship Cancer Institute (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075164277","display_name":"Jolinta Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jolinta Lin","raw_affiliation_strings":["Emory Univ. (United States)","Winship Cancer Institute (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112323319","display_name":"Shannon Kahn","orcid":null},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Kahn","raw_affiliation_strings":["Winship Cancer Institute (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032332424","display_name":"Hui\u2010Kuo G. Shu","orcid":"https://orcid.org/0000-0002-4060-0874"},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui-Kuo Shu","raw_affiliation_strings":["Emory Univ. (United States)","Winship Cancer Institute (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002507883","display_name":"Jeffrey D. Bradley","orcid":"https://orcid.org/0000-0003-3047-3151"},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Bradley","raw_affiliation_strings":["Winship Cancer Institute (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365641","display_name":"Tian Liu","orcid":"https://orcid.org/0000-0001-8944-6305"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Liu","raw_affiliation_strings":["Winship Cancer Institute (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100619090","display_name":"Xiaofeng Yang","orcid":"https://orcid.org/0000-0001-9023-5855"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210100202","display_name":"Piedmont Cancer Institute","ror":"https://ror.org/011w7ja64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100202"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Yang","raw_affiliation_strings":["Winship Cancer Institute (United States)","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210100202","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5011903902"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210100202","https://openalex.org/I4390039307"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02572423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6533133387565613},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5873669981956482},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5192237496376038},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49229514598846436},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32721614837646484},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.05863898992538452}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6533133387565613},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5873669981956482},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5192237496376038},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49229514598846436},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32721614837646484},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.05863898992538452},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2611809","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2611809","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1641498739","https://openalex.org/W1988138737","https://openalex.org/W2008400075","https://openalex.org/W2016695839","https://openalex.org/W2025633794","https://openalex.org/W2061729089","https://openalex.org/W2224254632","https://openalex.org/W2295107390","https://openalex.org/W2584466409","https://openalex.org/W2751069891","https://openalex.org/W2925359305","https://openalex.org/W3026862239","https://openalex.org/W3033962650","https://openalex.org/W3034067600","https://openalex.org/W3082962134","https://openalex.org/W3093080646","https://openalex.org/W3125540588","https://openalex.org/W3130605670","https://openalex.org/W3134644179","https://openalex.org/W3158735907","https://openalex.org/W3163944191","https://openalex.org/W3176482836","https://openalex.org/W3185052070","https://openalex.org/W4213315373","https://openalex.org/W4229875160","https://openalex.org/W4233195580","https://openalex.org/W4243588327","https://openalex.org/W4248595899","https://openalex.org/W6638444622","https://openalex.org/W6647427982","https://openalex.org/W6654704764","https://openalex.org/W6681852857","https://openalex.org/W6733549453","https://openalex.org/W6778941512"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W2033914206","https://openalex.org/W2042327336"],"abstract_inverted_index":{"Multiparameter":[0],"magnetic":[1],"resonance":[2],"imaging":[3],"(mp-MRI)":[4],"commonly":[5,20],"used":[6,21,125,165],"modality":[7],"for":[8,52,70,166,268],"segmentation":[9,28,73,94,146,155,159,215],"of":[10,29,45,64,74,87,112,147,214,216,229,238,248],"glioma":[11],"and":[12,38,61,93,96,185,196,207,218,223,233,236,242,256],"its":[13,269],"subregions,":[14,220],"whereas":[15],"RT":[16],"therapy":[17],"is":[18,34,105,124,141],"a":[19,35,65,91,97],"treatment":[22],"modality.":[23],"Current":[24],"workflow":[25],"includes":[26],"manual":[27,199],"brain":[30,75,113,259],"tumor":[31,76,118,158,189,191,260],"sub-regions,":[32],"which":[33,115],"very":[36],"lengthy":[37],"laborious":[39],"process":[40],"given":[41],"that":[42],"different":[43,138],"sets":[44],"MR":[46],"images":[47],"have":[48],"to":[49,107,126,132,253,272],"be":[50],"analyzed":[51],"an":[53,71],"appropriate":[54],"diagnosis.":[55],"This":[56,140],"work":[57,250],"focuses":[58],"on":[59,177],"implementing":[60],"testing":[62],"feasibility":[63],"new":[66],"deep":[67],"learning":[68],"model":[69],"automatic":[72],"sub-regions.":[77],"Our":[78],"proposed":[79,169,264],"method,":[80,265],"named":[81],"hierarchical":[82,98,121],"substructural":[83],"activation":[84,129],"network,":[85],"consists":[86],"three":[88],"main":[89],"parts:":[90],"detection":[92,103],"module,":[95],"convolutional":[99,122],"block.":[100],"While":[101],"the":[102,109,120,134,144,151,202],"module":[104],"employed":[106],"detect":[108],"view-of-interests":[110],"(VOIs)":[111],"tumor,":[114],"include":[116],"all":[117],"sub-structures,":[119],"block":[123],"derive":[127],"structural":[128],"map":[130],"(SAM)":[131],"boost":[133],"classification":[135],"accuracy":[136],"between":[137],"structures.":[139],"followed":[142],"by":[143,154,262],"semantic":[145],"each":[148],"substructure":[149],"within":[150],"detected":[152],"VOI":[153],"module.":[156],"Brain":[157],"challenge":[160],"(BraTS)":[161],"2020":[162],"dataset":[163],"was":[164],"evaluating":[167],"our":[168,225,263],"framework.":[170],"We":[171],"performed":[172],"five-fold":[173],"cross":[174],"validation":[175],"experiments":[176],"100":[178],"BraTS":[179],"datasets.":[180],"Three":[181],"substructures,":[182],"i.e.,":[183],"necrosis":[184,217],"non-enhancing,":[186],"edema,":[187,221],"enhancing":[188],"(ET),":[190],"core":[192],"(TC),":[193],"were":[194],"segmented":[195],"compared":[197],"with":[198],"contours":[200],"using":[201],"Dice":[203],"similarity":[204],"coefficient":[205],"(DSC)":[206],"mean":[208],"surface":[209],"distance":[210],"(MSD).":[211],"In":[212],"terms":[213],"non-enhancing":[219],"ET":[222],"TC,":[224],"method":[226],"yielded":[227],"DSC":[228],"0.69±0.24,":[230],"0.89±0.09,":[231],"0.80±0.14,":[232],"0.88±0.11,":[234],"respectively,":[235],"MSD":[237],"2.01±2.75,":[239],"0.63±0.58,":[240],"0.98±1.10":[241],"1.74±1.06":[243],"mm,":[244],"respectively.":[245],"Preliminary":[246],"results":[247],"this":[249],"show":[251],"promise":[252],"both":[254],"accurately":[255],"automatically":[257],"segment":[258],"subregions":[261],"providing":[266],"motivation":[267],"clinical":[270,274],"implementation":[271],"improve":[273],"workflow.":[275]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}