{"id":"https://openalex.org/W4221022099","doi":"https://doi.org/10.1117/12.2611648","title":"Clinical CT-based assessment of trabecular bone shear modulus using nonlinear finite element modelling","display_name":"Clinical CT-based assessment of trabecular bone shear modulus using nonlinear finite element modelling","publication_year":2022,"publication_date":"2022-03-30","ids":{"openalex":"https://openalex.org/W4221022099","doi":"https://doi.org/10.1117/12.2611648"},"language":"en","primary_location":{"id":"doi:10.1117/12.2611648","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2611648","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056977107","display_name":"Indranil Guha","orcid":"https://orcid.org/0000-0002-6691-7204"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Indranil Guha","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018595476","display_name":"Xiaoliu Zhang","orcid":"https://orcid.org/0000-0002-2085-3997"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoliu Zhang","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033203259","display_name":"Punam K. Saha","orcid":"https://orcid.org/0000-0003-1576-118X"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Punam K. Saha","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056977107"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04360935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":null,"first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/finite-element-method","display_name":"Finite element method","score":0.6875162720680237},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5859214067459106},{"id":"https://openalex.org/keywords/cancellous-bone","display_name":"Cancellous bone","score":0.5217681527137756},{"id":"https://openalex.org/keywords/modulus","display_name":"Modulus","score":0.49749234318733215},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"Osteoporosis","score":0.477438747882843},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.4647219777107239},{"id":"https://openalex.org/keywords/cadaveric-spasm","display_name":"Cadaveric spasm","score":0.45393240451812744},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"Quantitative computed tomography","score":0.4215150773525238},{"id":"https://openalex.org/keywords/shear-modulus","display_name":"Shear modulus","score":0.4210163652896881},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.4190727472305298},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.417469322681427},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4103385806083679},{"id":"https://openalex.org/keywords/bone-density","display_name":"Bone density","score":0.35990530252456665},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.2671317458152771},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.20134323835372925},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.19503262639045715},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19023671746253967},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.18393364548683167},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11721119284629822}],"concepts":[{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.6875162720680237},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5859214067459106},{"id":"https://openalex.org/C2776350087","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cancellous bone","level":2,"score":0.5217681527137756},{"id":"https://openalex.org/C193867417","wikidata":"https://www.wikidata.org/wiki/Q6889814","display_name":"Modulus","level":2,"score":0.49749234318733215},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.477438747882843},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.4647219777107239},{"id":"https://openalex.org/C175696284","wikidata":"https://www.wikidata.org/wiki/Q986524","display_name":"Cadaveric spasm","level":2,"score":0.45393240451812744},{"id":"https://openalex.org/C2777425516","wikidata":"https://www.wikidata.org/wiki/Q17083560","display_name":"Quantitative computed tomography","level":4,"score":0.4215150773525238},{"id":"https://openalex.org/C41279357","wikidata":"https://www.wikidata.org/wiki/Q461466","display_name":"Shear modulus","level":2,"score":0.4210163652896881},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.4190727472305298},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.417469322681427},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4103385806083679},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.35990530252456665},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.2671317458152771},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20134323835372925},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19503262639045715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19023671746253967},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.18393364548683167},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11721119284629822},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2611648","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2611648","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W371399941","https://openalex.org/W1554441783","https://openalex.org/W1606867770","https://openalex.org/W1964581145","https://openalex.org/W1969210223","https://openalex.org/W1975738649","https://openalex.org/W1976387068","https://openalex.org/W1988005311","https://openalex.org/W1990183936","https://openalex.org/W2013745320","https://openalex.org/W2016441011","https://openalex.org/W2020775263","https://openalex.org/W2027544354","https://openalex.org/W2048250502","https://openalex.org/W2058232189","https://openalex.org/W2063896810","https://openalex.org/W2064082484","https://openalex.org/W2066056548","https://openalex.org/W2074747564","https://openalex.org/W2078515578","https://openalex.org/W2090867610","https://openalex.org/W2102024055","https://openalex.org/W2105510043","https://openalex.org/W2108300876","https://openalex.org/W2113523811","https://openalex.org/W2114714759","https://openalex.org/W2117369607","https://openalex.org/W2123822872","https://openalex.org/W2123897227","https://openalex.org/W2411893017","https://openalex.org/W2591065644","https://openalex.org/W2594042697","https://openalex.org/W2765968837","https://openalex.org/W2788739250","https://openalex.org/W3010585331","https://openalex.org/W3012798044","https://openalex.org/W3093679250","https://openalex.org/W3132371893","https://openalex.org/W4237672378","https://openalex.org/W4242508763","https://openalex.org/W4285377895","https://openalex.org/W6635278838","https://openalex.org/W6677333712","https://openalex.org/W6678639457","https://openalex.org/W6735822337","https://openalex.org/W6790941170"],"related_works":["https://openalex.org/W4235980960","https://openalex.org/W4239572149","https://openalex.org/W4251441142","https://openalex.org/W2059883365","https://openalex.org/W1988555809","https://openalex.org/W1938612101","https://openalex.org/W2109038795","https://openalex.org/W2055264824","https://openalex.org/W2079516902","https://openalex.org/W4205715185"],"abstract_inverted_index":{"Osteoporosis":[0],"is":[1,47,68],"an":[2],"age-related":[3],"bone":[4,8,12,25,57,248],"disease":[5,36],"causing":[6],"increased":[7],"loss":[9],"and":[10,14,28,30,38,70,138,161,166,182,200],"enhanced":[11],"fragility":[13],"fracture-risk.":[15],"Osteoporotic":[16],"imaging":[17,43,67,218],"plays":[18,31],"important":[19,32],"roles":[20,33],"in":[21,34,232],"quantitative":[22],"assessment":[23],"of":[24,55,81,106,123,169,223,226,241,247],"quality,":[26],"strength,":[27],"fracture-risk,":[29],"evaluating":[35],"severity":[37],"treatment":[39],"planning.":[40],"High-resolution":[41],"CT":[42,66,119,165,217],"on":[44,64],"dedicated":[45],"scanners":[46],"used":[48,151],"for":[49,97,238,245],"finite":[50],"element":[51],"(FE)":[52],"analysis":[53,225],"(FEA)":[54],"trabecular":[56],"(Tb)":[58],"microstructure.":[59],"However,":[60],"Tb":[61,82,99,107,180,227],"micro":[62],"FEA":[63,95,176,214],"clinical":[65,164,216],"challenging":[69],"yet":[71],"to":[72,76,152],"be":[73],"established":[74],"due":[75],"difficulties":[77],"with":[78,126,209],"binary":[79,239],"segmentation":[80,105,240],"at":[83,229],"relatively":[84,230],"low-resolution.":[85],"Here,":[86],"we":[87],"present":[88],"a":[89],"CT-based":[90],"material":[91],"density":[92],"adjusted":[93],"nonlinear":[94],"method":[96,158],"computing":[98],"shear":[100,154,191],"modulus,":[101],"while":[102,243],"avoiding":[103],"explicit":[104],"micro-network.":[108],"FE":[109],"meshes":[110],"were":[111,132,142,194],"constructed":[112],"over":[113,185],"upright":[114],"cylindrical":[115],"VOIs":[116],"derived":[117,143],"from":[118,144],"scans":[120,168],"after":[121],"alignment":[122],"tibia":[124],"axes":[125],"the":[127,221,236],"image":[128],"axes.":[129],"Image":[130],"voxels":[131],"modelled":[133],"as":[134],"cubical":[135],"mesh":[136],"elements,":[137],"their":[139,145],"mechanical":[140],"properties":[141],"CT-derived":[146,190],"ash-density.":[147],"Tibiofemoral":[148],"direction":[149],"was":[150,159,188,207],"define":[153],"loading":[155],"directions.":[156],"The":[157],"optimized":[160],"evaluated":[162],"using":[163,215],"micro-CT":[167],"cadaveric":[170],"ankle":[171],"specimens":[172],"(n":[173],"=":[174,198],"10).":[175],"stress":[177],"propagation":[178],"along":[179],"microstructures":[181],"nominal":[183],"leakages":[184],"marrow":[186],"space":[187],"confirmed.":[189],"modulus":[192],"values":[193],"highly":[195],"reproducible":[196],"(ICC":[197],"0.98)":[199],"high":[201],"linear":[202],"correlation":[203],"(r":[204],"\u2265":[205],"0.83)":[206],"observed":[208],"micro-CT-derived":[210],"reference":[211],"values.":[212],"Nonlinear":[213],"will":[219],"broaden":[220],"scope":[222],"micro-mechanical":[224],"network":[228],"low":[231],"vivo":[233],"resolution":[234],"alleviating":[235],"need":[237],"Tb,":[242],"accounting":[244],"microdistribution":[246],"minerals.":[249]},"counts_by_year":[],"updated_date":"2026-01-15T23:16:33.117629","created_date":"2025-10-10T00:00:00"}