{"id":"https://openalex.org/W3129613581","doi":"https://doi.org/10.1117/12.2581387","title":"Automated detection and quantification of Wilms\u2019 Tumor 1-positive cells in murine diabetic kidney disease","display_name":"Automated detection and quantification of Wilms\u2019 Tumor 1-positive cells in murine diabetic kidney disease","publication_year":2021,"publication_date":"2021-02-13","ids":{"openalex":"https://openalex.org/W3129613581","doi":"https://doi.org/10.1117/12.2581387","mag":"3129613581","pmid":"https://pubmed.ncbi.nlm.nih.gov/34366543"},"language":"en","primary_location":{"id":"doi:10.1117/12.2581387","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2581387","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2021: Digital Pathology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8345331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102941048","display_name":"Darshana Govind","orcid":"https://orcid.org/0000-0001-7779-4994"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darshana Govind","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004281481","display_name":"Briana A. Santo","orcid":"https://orcid.org/0000-0001-8850-2985"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Briana A. Santo","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041397853","display_name":"Brandon Ginley","orcid":null},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Ginley","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006295616","display_name":"Rabi Yacoub","orcid":"https://orcid.org/0000-0002-0479-4667"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rabi Yacoub","raw_affiliation_strings":["Department of Internal Medicine, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030215181","display_name":"Avi Z. Rosenberg","orcid":"https://orcid.org/0000-0003-2356-950X"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Z. Rosenberg","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD","Johns Hopkins Univ. School of Medicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048109211","display_name":"Kuang\u2010Yu Jen","orcid":"https://orcid.org/0000-0003-2815-5912"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuang-Yu Jen","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of California at Davis, CA","Univ. of California, Davis (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of California at Davis, CA","institution_ids":[]},{"raw_affiliation_string":"Univ. of California, Davis (United States)","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026477894","display_name":"Vighnesh Walavalkar","orcid":"https://orcid.org/0000-0003-0918-1525"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vighnesh Walavalkar","raw_affiliation_strings":["Department of Pathology, University of California San Francisco, San Francisco, CA","Univ. of California, San Francisco (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Univ. of California, San Francisco (United States)","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016601438","display_name":"Gregory E. Wilding","orcid":"https://orcid.org/0000-0001-5569-9363"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory E. Wilding","raw_affiliation_strings":["Department of Biostatistics, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058046835","display_name":"Amber Worral","orcid":null},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber M. Worral","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046684086","display_name":"Imtiaz Mohammad","orcid":null},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imtiaz Mohammad","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044061952","display_name":"Pinaki Sarder","orcid":"https://orcid.org/0000-0003-2450-5233"},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pinaki Sarder","raw_affiliation_strings":["Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","Univ. at Buffalo (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Univ. at Buffalo (United States)","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5102941048"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":null,"apc_paid":null,"fwci":0.4067,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58112032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"11603","issue":null,"first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/podocyte","display_name":"Podocyte","score":0.8129026889801025},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5498179197311401},{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms' tumor","score":0.5428902506828308},{"id":"https://openalex.org/keywords/kidney","display_name":"Kidney","score":0.5210320949554443},{"id":"https://openalex.org/keywords/immunofluorescence","display_name":"Immunofluorescence","score":0.46067744493484497},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"Kidney disease","score":0.4191140830516815},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35933804512023926},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3248550593852997},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21792098879814148},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.14608857035636902},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.1208600103855133},{"id":"https://openalex.org/keywords/proteinuria","display_name":"Proteinuria","score":0.10823875665664673}],"concepts":[{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.8129026889801025},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5498179197311401},{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.5428902506828308},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5210320949554443},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.46067744493484497},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4191140830516815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35933804512023926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3248550593852997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21792098879814148},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14608857035636902},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1208600103855133},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.10823875665664673}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2581387","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2581387","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2021: Digital Pathology","raw_type":"proceedings-article"},{"id":"pmid:34366543","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34366543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8345331","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8345331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8345331","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8345331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.47999998927116394,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W621251951","https://openalex.org/W1597336200","https://openalex.org/W2033753222","https://openalex.org/W2037789405","https://openalex.org/W2059264239","https://openalex.org/W2163406006","https://openalex.org/W2301340697","https://openalex.org/W2320243674","https://openalex.org/W2963896025","https://openalex.org/W3102660688"],"related_works":["https://openalex.org/W2775156232","https://openalex.org/W2924161946","https://openalex.org/W4311934215","https://openalex.org/W3172558102","https://openalex.org/W2340540849","https://openalex.org/W4240069654","https://openalex.org/W2062263961","https://openalex.org/W4220868919","https://openalex.org/W2124364796","https://openalex.org/W3041277010"],"abstract_inverted_index":{"label-free":[0],"podocyte":[1],"and":[2],"PEC":[3],"identification":[4,31],"in":[5,49],"brightfield":[6],"images.":[7],"Our":[8],"method":[9],"detected":[10],"WT1-positive":[11,47],"cells":[12,48],"with":[13,21],"high":[14],"sensitivity/specificity":[15],"(0.87/0.92).":[16],"Additionally,":[17],"our":[18],"algorithm":[19],"performed":[20],"a":[22],"higher":[23],"Cohen's":[24],"kappa":[25],"(0.85)":[26],"than":[27],"the":[28],"average":[29],"manual":[30],"by":[32],"three":[33],"renal":[34],"pathologists":[35],"(0.78).":[36],"We":[37],"propose":[38],"that":[39],"this":[40],"pipeline":[41],"will":[42],"enable":[43],"accurate":[44],"detection":[45],"of":[46],"research":[50],"applications.":[51]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}