{"id":"https://openalex.org/W3131821960","doi":"https://doi.org/10.1117/12.2581057","title":"Deep learning-based aggressive progression prediction from CT images of hepatocellular carcinoma","display_name":"Deep learning-based aggressive progression prediction from CT images of hepatocellular carcinoma","publication_year":2021,"publication_date":"2021-02-12","ids":{"openalex":"https://openalex.org/W3131821960","doi":"https://doi.org/10.1117/12.2581057","mag":"3131821960"},"language":"en","primary_location":{"id":"doi:10.1117/12.2581057","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2581057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2021: Computer-Aided Diagnosis","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066050326","display_name":"Meiqing Pan","orcid":null},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"meiqing pan","raw_affiliation_strings":["Beihang Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Beihang Univ. (China)","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114723703","display_name":"Zhenchao Tang","orcid":"https://orcid.org/0009-0004-2860-3900"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]},{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenchao Tang","raw_affiliation_strings":["Beihang Univ. (China)","Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Beihang Univ. (China)","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112328557","display_name":"Sirui Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sirui Fu","raw_affiliation_strings":["Zhuhai People's Hospital (China)"],"affiliations":[{"raw_affiliation_string":"Zhuhai People's Hospital (China)","institution_ids":["https://openalex.org/I4210105182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030403651","display_name":"Wei Mu","orcid":"https://orcid.org/0000-0001-7970-8666"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]},{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Mu","raw_affiliation_strings":["Beihang Univ. (China)","Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Beihang Univ. (China)","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436741","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0002-4257-696X"},"institutions":[{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Zhuhai People's Hospital (China)"],"affiliations":[{"raw_affiliation_string":"Zhuhai People's Hospital (China)","institution_ids":["https://openalex.org/I4210105182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022416946","display_name":"Xiaoqun Li","orcid":"https://orcid.org/0000-0001-9176-090X"},"institutions":[{"id":"https://openalex.org/I4210107594","display_name":"Zhongshan People's Hospital","ror":"https://ror.org/01x5dfh38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107594"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqun Li","raw_affiliation_strings":["Zhongshan City People's Hospital (China)"],"affiliations":[{"raw_affiliation_string":"Zhongshan City People's Hospital (China)","institution_ids":["https://openalex.org/I4210107594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323413","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0002-1523-2651"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["Beihang Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Beihang Univ. (China)","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023266686","display_name":"Ligong Lu","orcid":"https://orcid.org/0000-0003-1405-0052"},"institutions":[{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ligong Lu","raw_affiliation_strings":["Zhuhai People's Hospital (China)"],"affiliations":[{"raw_affiliation_string":"Zhuhai People's Hospital (China)","institution_ids":["https://openalex.org/I4210105182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100429270","display_name":"Jie Tian","orcid":"https://orcid.org/0000-0003-0498-0432"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]},{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Tian","raw_affiliation_strings":["Beihang Univ. (China)","Institute of Automation (China)","Univ. of Chinese Academy of Sciences (China)"],"affiliations":[{"raw_affiliation_string":"Beihang Univ. (China)","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"Univ. of Chinese Academy of Sciences (China)","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5066050326"],"corresponding_institution_ids":["https://openalex.org/I82880672"],"apc_list":null,"apc_paid":null,"fwci":0.4124,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60110743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"104","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.8882845640182495},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7249425053596497},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5502455830574036},{"id":"https://openalex.org/keywords/hepatectomy","display_name":"Hepatectomy","score":0.4587211608886719},{"id":"https://openalex.org/keywords/liver-disease","display_name":"Liver disease","score":0.44196534156799316},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4323809742927551},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.416384756565094},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.4116226136684418},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.37457597255706787},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.36725056171417236},{"id":"https://openalex.org/keywords/gastroenterology","display_name":"Gastroenterology","score":0.3635072112083435},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3575040102005005},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.27137595415115356},{"id":"https://openalex.org/keywords/resection","display_name":"Resection","score":0.2437078356742859},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.21158474683761597},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.10581690073013306}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8882845640182495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7249425053596497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5502455830574036},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.4587211608886719},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.44196534156799316},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4323809742927551},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.416384756565094},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4116226136684418},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.37457597255706787},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36725056171417236},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3635072112083435},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3575040102005005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27137595415115356},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.2437078356742859},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21158474683761597},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10581690073013306}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2581057","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2581057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2021: Computer-Aided Diagnosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417822880","https://openalex.org/W628600844","https://openalex.org/W1570838273","https://openalex.org/W2410885201","https://openalex.org/W2385390897","https://openalex.org/W3172842848","https://openalex.org/W2418745692","https://openalex.org/W2404951810","https://openalex.org/W2800415451","https://openalex.org/W2337719538"],"abstract_inverted_index":{"Repeat":[0],"liver":[1],"resection":[2],"or":[3,24,74],"transarterial":[4],"chemoembolization":[5],"(TACE)":[6],"can":[7],"be":[8],"used":[9],"for":[10,105],"disease":[11,30],"progression":[12,31,111],"(PD)":[13],"of":[14,109,112],"hepatocellular":[15],"carcinoma":[16,114],"(HCC),":[17],"but":[18],"when":[19],"patients":[20,71],"developed":[21],"extrahepatic":[22],"metastasis":[23],"macrovascular":[25],"invasion":[26],"which":[27],"was":[28,40,56,65,87],"aggressive":[29],"(aggressive-PD),":[32],"the":[33,50,110],"treatments":[34],"became":[35],"a":[36,61,90],"challenge.":[37],"Therefore,":[38],"it":[39],"meaningful":[41],"to":[42,67],"predict":[43,68],"aggressive-PD":[44],"as":[45,47],"early":[46],"possible":[48],"considering":[49],"current":[51],"prediction":[52,108],"method":[53],"in":[54],"clinical":[55],"unreliable.":[57],"In":[58],"this":[59],"study,":[60],"deep":[62,84,133],"learning":[63,85,134],"model":[64,94,101],"conducted":[66],"aggressive-PD.":[69],"333":[70],"receiving":[72],"hepatectomy":[73],"TACE":[75],"were":[76,129],"enrolled":[77],"from":[78,89],"five":[79],"hospitals.":[80],"For":[81],"each":[82],"patient,":[83],"score":[86],"calculated":[88],"convolutional":[91],"neural":[92],"network":[93],"constructed":[95],"based":[96],"on":[97],"resnet":[98],"block.":[99],"The":[100],"showed":[102,126],"excellent":[103],"performance":[104],"individualized,":[106],"non-invasive":[107],"Hepatocellular":[113],"(training":[115],"set:":[116,120],"ACC=75.61%,":[117],"AUC=0.81,":[118],"validation":[119],"ACC=87.36%,":[121],"AUC=0.82).":[122],"Pearson":[123],"correlation":[124],"analysis":[125],"albumin":[127],"concentration":[128],"significantly":[130],"correlated":[131],"with":[132],"score.":[135]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
