{"id":"https://openalex.org/W3131143657","doi":"https://doi.org/10.1117/12.2580725","title":"Quantitative analysis of Alzheimer\u2019s disease pathology in glioblastoma patients","display_name":"Quantitative analysis of Alzheimer\u2019s disease pathology in glioblastoma patients","publication_year":2021,"publication_date":"2021-02-12","ids":{"openalex":"https://openalex.org/W3131143657","doi":"https://doi.org/10.1117/12.2580725","mag":"3131143657"},"language":"en","primary_location":{"id":"doi:10.1117/12.2580725","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2580725","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2021: Digital Pathology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090441302","display_name":"Michael Brehler","orcid":"https://orcid.org/0000-0002-4663-6587"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Brehler","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089858638","display_name":"Allison Lowman","orcid":"https://orcid.org/0000-0002-2520-8145"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Lowman","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073240775","display_name":"Samuel Bobholz","orcid":"https://orcid.org/0000-0003-1525-7418"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Bobholz","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080491768","display_name":"Sean D. McGarry","orcid":"https://orcid.org/0000-0003-4937-2780"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean McGarry","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091546375","display_name":"Jennifer Connelly","orcid":"https://orcid.org/0000-0002-6122-8573"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Connelly","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109553905","display_name":"Elizabeth J. Cochran","orcid":null},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Cochran","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032574031","display_name":"Peter S. LaViolette","orcid":"https://orcid.org/0000-0002-9602-6891"},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter LaViolette","raw_affiliation_strings":["Medical College of Wisconsin (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin (United States)","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.01603448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.46059998869895935,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.46059998869895935,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.4059000015258789,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.4050000011920929,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.7675750255584717},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.595257043838501},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5318690538406372},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4672168493270874},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4152769446372986},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.1915888488292694}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7675750255584717},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.595257043838501},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5318690538406372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4672168493270874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4152769446372986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1915888488292694}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2580725","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2580725","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2021: Digital Pathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Purpose:":[0],"Recent":[1],"studies":[2,247],"suggest":[3],"an":[4,148],"inverse":[5],"association":[6],"between":[7,131],"cancer":[8],"in":[9,21,66,162,170,199,241,252,269],"general":[10],"and":[11,58,97,115,118,129,160,169,182,195,224,232,243,250,264],"Alzheimer\u2019s":[12],"disease":[13],"(AD),":[14],"suggesting":[15],"that":[16],"there":[17],"are":[18],"common":[19,95],"factors":[20,268],"these":[22],"diseases.":[23],"In":[24],"this":[25],"study,":[26],"we":[27,49],"demonstrate":[28],"a":[29,45,80,108,140],"complete":[30],"workflow":[31,76],"to":[32,41,93,112,259],"streamline":[33],"the":[34,51,135,190,193,200,204,218,221,253],"analysis":[35],"of":[36,47,53,64,151,164,172,179,192,217,229,234,248,255,272],"stained":[37,123,154],"histological":[38,215],"brain":[39,201,219],"samples":[40,85,102,187,216],"reduce":[42],"user-dependence.":[43],"As":[44],"proof":[46],"concept,":[48],"investigate":[50],"influence":[52],"Amyloid":[54],"Beta":[55],"(Aβ)":[56],"plaques":[57],"hyperphosphorylated":[59],"Tau":[60],"protein":[61],"(pTau),":[62],"hallmarks":[63],"AD,":[65],"Glioblastoma":[67],"(GBM)":[68],"patients.":[69,273],"Methods:":[70],"The":[71,100,210],"automated":[72],"digital":[73],"histology":[74],"processing":[75,120,214],"is":[77],"demonstrated":[78],"on":[79],"10-patient":[81],"cohort.":[82],"First,":[83],"tissue":[84,101,119],"were":[86,103,125,157],"taken":[87],"at":[88],"autopsy":[89],"from":[90],"regions":[91,156],"known":[92],"be":[94],"Aβ":[96,168,183,244,251],"pTau":[98,181,242,249],"hotspots.":[99],"then":[104,126],"subclassified":[105],"regionally":[106],"using":[107,139],"ResNet50":[109],"neural":[110],"network":[111],"separate":[113],"gray":[114],"white":[116],"matter,":[117],"artifacts.":[121,235],"Positively":[122,153],"areas":[124],"automatically":[127,158],"detected":[128,159],"analyzed":[130],"subjects.":[132],"We":[133],"evaluated":[134],"automatic":[136],"sample":[137,155],"classification":[138],"5-fold":[141],"cross":[142],"validation.":[143],"Results:":[144],"Cross":[145],"validation":[146],"achieved":[147],"overall":[149],"accuracy":[150],"93.88%.":[152],"present":[161],"six":[163],"ten":[165,173],"patients":[166,174],"for":[167,175,213],"three":[171],"pTau.":[176],"General":[177],"accumulation":[178,198],"both":[180],"calculated":[184],"over":[185],"all":[186],"correlated":[188],"with":[189],"age":[191],"patient,":[194],"showed":[196],"decreased":[197],"hemisphere":[202],"where":[203],"primary":[205],"tumor":[206,262],"was":[207],"located.":[208],"Conclusion:":[209],"proposed":[211],"method":[212],"automates":[220],"time":[222],"consuming":[223],"error":[225],"prone":[226],"manual":[227],"segmentation":[228],"grey":[230],"matter":[231],"removal":[233],"Our":[236],"study":[237],"highlights":[238],"hemispheric":[239],"differences":[240],"accumulation.":[245],"Future":[246],"presence":[254],"GBM":[256],"will":[257],"help":[258],"understand":[260],"how":[261],"location":[263],"growth":[265],"affect":[266],"micro-environmental":[267],"larger":[270],"cohorts":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}