{"id":"https://openalex.org/W3012544034","doi":"https://doi.org/10.1117/12.2551393","title":"Using \"lesion-habitat\" radiomics to distinguish radiation necrosis from tumor recurrence on post-treatment MRI in metastatic brain tumors","display_name":"Using \"lesion-habitat\" radiomics to distinguish radiation necrosis from tumor recurrence on post-treatment MRI in metastatic brain tumors","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3012544034","doi":"https://doi.org/10.1117/12.2551393","mag":"3012544034"},"language":"en","primary_location":{"id":"doi:10.1117/12.2551393","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2551393","pdf_url":null,"source":{"id":"https://openalex.org/S4306519512","display_name":"Medical Imaging 2020: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Computer-Aided Diagnosis","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044506873","display_name":"Ram\u00f3n Correa","orcid":"https://orcid.org/0000-0003-2247-7777"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramon Correa","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082381446","display_name":"Lei Qiu","orcid":"https://orcid.org/0000-0002-1852-1176"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiu Lei","raw_affiliation_strings":["Cleveland Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic (United States)","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050278592","display_name":"Jonathan Chen","orcid":"https://orcid.org/0000-0003-4907-0061"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Chen","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046257486","display_name":"Johnathan Zeng","orcid":"https://orcid.org/0000-0002-0838-9263"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johnathan Zeng","raw_affiliation_strings":["Cleveland Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic (United States)","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033599840","display_name":"Jennifer S. Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Yu","raw_affiliation_strings":["Cleveland Clinic (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic (United States)","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042392208","display_name":"Pallavi Tiwari","orcid":"https://orcid.org/0000-0001-9477-4856"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pallavi Tiwari","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3524,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62909781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"105","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7468974590301514},{"id":"https://openalex.org/keywords/radiosurgery","display_name":"Radiosurgery","score":0.6891989707946777},{"id":"https://openalex.org/keywords/lesion","display_name":"Lesion","score":0.6228256821632385},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.5747759342193604},{"id":"https://openalex.org/keywords/fluid-attenuated-inversion-recovery","display_name":"Fluid-attenuated inversion recovery","score":0.5519208908081055},{"id":"https://openalex.org/keywords/necrosis","display_name":"Necrosis","score":0.4645296037197113},{"id":"https://openalex.org/keywords/brain-tumor","display_name":"Brain tumor","score":0.4475015699863434},{"id":"https://openalex.org/keywords/stereotactic-biopsy","display_name":"Stereotactic biopsy","score":0.4373067021369934},{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.4327201843261719},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.4252234101295471},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3270438015460968},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.30859076976776123}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7468974590301514},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.6891989707946777},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6228256821632385},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5747759342193604},{"id":"https://openalex.org/C101070640","wikidata":"https://www.wikidata.org/wiki/Q3737215","display_name":"Fluid-attenuated inversion recovery","level":3,"score":0.5519208908081055},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4645296037197113},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4475015699863434},{"id":"https://openalex.org/C2778256017","wikidata":"https://www.wikidata.org/wiki/Q3640183","display_name":"Stereotactic biopsy","level":3,"score":0.4373067021369934},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4327201843261719},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4252234101295471},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3270438015460968},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.30859076976776123}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2551393","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2551393","pdf_url":null,"source":{"id":"https://openalex.org/S4306519512","display_name":"Medical Imaging 2020: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Computer-Aided Diagnosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.550000011920929}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2397888002","https://openalex.org/W2356247871","https://openalex.org/W2373716292","https://openalex.org/W2381429000","https://openalex.org/W2364564193","https://openalex.org/W2393352769","https://openalex.org/W2131742827","https://openalex.org/W4389341328","https://openalex.org/W2277147420","https://openalex.org/W2173310068"],"abstract_inverted_index":{"About":[0],"a":[1,14,46,113,146,171,219,266,271,304,309],"third":[2],"of":[3,49,56,93,182,221,235,301,306,311,323],"all":[4,57,240],"cancer":[5],"patients":[6,18,35,184],"develop":[7],"brain":[8,20,59],"metastases.":[9],"Stereotactic":[10],"radiosurgery":[11],"(SRS)":[12],"is":[13,38,83],"common":[15],"treatment":[16],"for":[17,34],"with":[19,154,303],"metastases":[21],"and":[22,141,158,195,214,308,358],"offers":[23],"excellent":[24],"tumor":[25,41,60,71,142,173,330,342,359],"control":[26],"rates.":[27],"However,":[28],"the":[29,89,126,130,189,236,247,276,287,314,340,351],"most":[30,248,280,352],"significant":[31],"clinical":[32],"challenge":[33],"after":[36],"SRS":[37],"reliably":[39,100],"differentiating":[40],"progression":[42],"from":[43,70,123,151,232,329,339],"radiation":[44,68,139,176,327,356],"necrosis,":[45,213],"side":[47],"effect":[48],"SRS,":[50],"which":[51],"occurs":[52],"in":[53,66,325,354,361],"about":[54],"20%":[55],"metastatic":[58],"patients.":[61,363],"The":[62,279],"current":[63],"diagnostic":[64],"accuracy":[65,322],"distinguishing":[67,326,355],"necrosis":[69,140,177,328,357],"recurrence":[72,360],"via":[73,164],"visual":[74],"inspection":[75],"by":[76,207,265],"expert":[77,209],"radiologists":[78],"on":[79,286,344],"routine":[80],"MRI":[81,243,346],"scans":[82],"50-60%.":[84],"Invasive":[85],"surgical":[86],"intervention":[87],"provides":[88],"only":[90],"definitive":[91],"means":[92],"diagnosis.":[94],"Therefore,":[95],"finding":[96],"non-invasive":[97],"markers":[98],"to":[99,137,256],"differentiate":[101],"between":[102],"these":[103],"diagnoses":[104],"are":[105],"urgently":[106],"needed.":[107],"In":[108],"this":[109],"work,":[110],"we":[111,251,296,319],"present":[112],"radiomic-pipeline":[114],"that":[115],"involves":[116],"capturing":[117],"texture":[118,223],"features":[119,224,259,282,333],"(Laws,":[120],"Haralick,":[121,226],"Gabor)":[122],"not":[124],"just":[125],"lesion":[127,237],"but":[128],"also":[129],"peri-lesion":[131],"environment":[132],"(defined":[133],"as":[134,169,188,210,349],"\u201clesion":[135],"habitat\u201d)":[136],"distinguish":[138],"recurrence.":[143,331],"We":[144],"obtained":[145,297,320],"discovery":[147,294],"dataset":[148],"(n=37":[149],"studies)":[150],"Cleveland":[152],"Clinic":[153],"post-Gd":[155],"T1w,":[156],"T2w,":[157],"FLAIR":[159,196],"volumes.":[160],"Patients":[161],"were":[162,198,205,230,283,347],"confirmed":[163],"histopathology":[165],"(biopsy":[166],"or":[167,175],"resection)":[168],"having":[170],"recurrent":[172],"(n=17)":[174],"(n=20).":[178],"A":[179],"separate":[180],"set":[181],"12":[183],"was":[185,263],"kept":[186],"blinded":[187,315],"hold-out\"":[190],"set.":[191,291],"Each":[192],"patient's":[193],"T2":[194],"volumes":[197],"co-registered":[199],"onto":[200],"Gd-T1w.":[201],"Lesion":[202],"habitat":[203,238],"sub-compartments":[204],"annotated":[206],"an":[208,298,321],"enhancing":[211,341],"tumor,":[212],"perilesional":[215],"edema.":[216],"Following":[217],"pre-processing,":[218],"total":[220],"4,740":[222],"(including":[225],"Gabor,":[227],"Laws,":[228],"CoLlAGe)":[229],"extracted":[231],"each":[233],"sub-compartment":[234],"across":[239],"three":[241],"available":[242],"sequences.":[244],"To":[245],"identify":[246],"discriminatory":[249,281,353],"features,":[250],"used":[252],"Wilcoxon":[253],"rank-sum":[254],"test":[255,290],"remove":[257],"correlated":[258],"(correlation":[260],"0.75).":[261],"This":[262],"followed":[264],"3-fold":[267],"cross-validation":[268],"scheme,":[269],"within":[270],"random":[272],"forest":[273],"classifier":[274],"using":[275],"training":[277],"cohort.":[278],"then":[284],"evaluated":[285],"hold":[288,316],"out":[289,317],"Within":[292],"our":[293],"set,":[295,318],"average":[299],"AUC":[300],".9781":[302],"sensitivity":[305],".91":[307],"specificity":[310],".92.":[312],"On":[313],"91%":[324],"Laws":[332],"(capturing":[334],"edges,":[335],"waves,":[336],"ripple":[337],"patterns)":[338],"region":[343],"Gd-T1w":[345],"identified":[348],"being":[350],"METs":[362]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}