{"id":"https://openalex.org/W3011529163","doi":"https://doi.org/10.1117/12.2550870","title":"Texture features distinguish benign cell clusters from adenocarcinomas on bile duct brushing cytology images","display_name":"Texture features distinguish benign cell clusters from adenocarcinomas on bile duct brushing cytology images","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3011529163","doi":"https://doi.org/10.1117/12.2550870","mag":"3011529163"},"language":"en","primary_location":{"id":"doi:10.1117/12.2550870","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2550870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Digital Pathology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058535937","display_name":"Shayan Monabbati","orcid":"https://orcid.org/0000-0003-0719-4007"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shayan Monabbati","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017466934","display_name":"Patrick Leo","orcid":"https://orcid.org/0000-0002-2248-0610"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Leo","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088228366","display_name":"Kaustav Bera","orcid":"https://orcid.org/0000-0001-9831-6000"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaustav Bera","raw_affiliation_strings":["Case Western Reserve Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037449345","display_name":"Behtash Ghazi Nezami","orcid":"https://orcid.org/0000-0002-6616-584X"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Behtash Nezami","raw_affiliation_strings":["Case Western Reserve Univ. School of Medicine, Univ. Hospitals Cleveland Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. School of Medicine, Univ. Hospitals Cleveland Medical Ctr. (United States)","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210153792","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080062807","display_name":"Claire W. Michael","orcid":"https://orcid.org/0000-0003-4729-8644"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire W. Michael","raw_affiliation_strings":["Case Western Reserve Univ. School of Medicine, Univ. Hospitals Cleveland Medical Ctr.  (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. School of Medicine, Univ. Hospitals Cleveland Medical Ctr.  (United States)","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210153792","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090215209","display_name":"Aparna Harbhajanka","orcid":"https://orcid.org/0000-0003-0766-7118"},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna Harbhajanka","raw_affiliation_strings":["Case Western Reserve Univ. School of Medicine, Univ. Hospitals Cleveland Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. School of Medicine, Univ. Hospitals Cleveland Medical Ctr. (United States)","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210153792","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027642699","display_name":"Anant Madabhushi","orcid":"https://orcid.org/0000-0002-5741-0399"},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anant Madabhushi","raw_affiliation_strings":["Case Western Reserve Univ. (United States)","Louis Stokes Cleveland Veterans Administrations Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis Stokes Cleveland Veterans Administrations Medical Ctr. (United States)","institution_ids":["https://openalex.org/I4210110978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03671036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.9462000131607056,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bile-duct","display_name":"Bile duct","score":0.5536857843399048},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.5360515117645264},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5268824696540833},{"id":"https://openalex.org/keywords/bile-duct-cancer","display_name":"Bile duct cancer","score":0.5268769860267639},{"id":"https://openalex.org/keywords/biopsy","display_name":"Biopsy","score":0.5056886672973633},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.45458850264549255},{"id":"https://openalex.org/keywords/cytology","display_name":"Cytology","score":0.42258724570274353},{"id":"https://openalex.org/keywords/dysplasia","display_name":"Dysplasia","score":0.4202170968055725},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.40530046820640564},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.39745163917541504},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26970112323760986}],"concepts":[{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.5536857843399048},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5360515117645264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5268824696540833},{"id":"https://openalex.org/C2775955815","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Bile duct cancer","level":3,"score":0.5268769860267639},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5056886672973633},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.45458850264549255},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.42258724570274353},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.4202170968055725},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40530046820640564},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39745163917541504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26970112323760986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2550870","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2550870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Digital Pathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4300000071525574,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4241457405","https://openalex.org/W2312415994","https://openalex.org/W1948933672","https://openalex.org/W3203656929","https://openalex.org/W2363974859","https://openalex.org/W2409523015","https://openalex.org/W2393123469","https://openalex.org/W1993691710","https://openalex.org/W2124832018","https://openalex.org/W3030393501"],"abstract_inverted_index":{"Bile":[0],"duct":[1,120],"cancer,":[2,12],"or":[3],"cholangiocarcinoma,":[4],"is":[5,41,117],"a":[6,106,118,222],"rare":[7],"and":[8,33,40,84,111,132,158,181,198,217,231,271,286,314,337,352,363,387,392,401,432],"aggressive":[9],"form":[10],"of":[11,27,29,50,75,88,98,109,139,142,150,172,183,200,224,248,255,294,303,389,394,419],"with":[13,44,378,398],"approximately":[14],"2,500":[15],"new":[16],"diagnoses":[17],"each":[18,239],"year":[19],"in":[20,37,95,129,190,215,358,428,435],"the":[21,73,96,99,148,272,317,379,412,429,436],"United":[22],"States.":[23],"Biliary":[24],"adenocarcinoma":[25,159,266],"comprise":[26],"90%":[28],"reported":[30],"cholangiocarcinoma":[31,51],"cases":[32],"often":[34,188],"presents":[35],"symptoms":[36],"later":[38],"stages":[39],"therefore":[42],"associated":[43],"poor":[45],"patient":[46],"outcomes.":[47],"Survival":[48],"rates":[49],"when":[52,65],"diagnosed":[53,66],"at":[54,283],"late":[55],"stage":[56],"are":[57,166,209],"6%,":[58],"but":[59],"can":[60],"be":[61],"improved":[62],"to":[63,91,115,146,154,168,211,251,365],"15%":[64],"early.":[67],"Many":[68],"previous":[69],"studies":[70],"have":[71,133],"investigated":[72],"role":[74,149],"quantitative":[76],"histomorphometric":[77],"(QH)":[78],"features":[79,153,187,208,237,289,344],"on":[80,160,243,425],"routinely":[81],"acquired":[82],"hematoxylin":[83],"eosin":[85],"(H&E)":[86],"slides":[87,131],"pancreatobiliary":[89],"biopsies":[90],"help":[92],"identify":[93],"malignancies":[94],"lining":[97],"biliary":[100,265],"tract.":[101],"The":[102,137,325,339],"biopsy":[103,116],"procedure":[104],"carries":[105],"high":[107],"risk":[108],"strictures":[110],"peritonitis.":[112],"An":[113],"alternative":[114],"bile":[119],"brushing":[121],"(BDB),":[122],"which":[123,256,304],"exclusively":[124],"contain":[125],"epithelial":[126],"cells":[127],"fixed":[128],"cytology":[130],"lower":[134],"complication":[135],"rates.":[136],"goal":[138],"this":[140],"proof":[141],"concept":[143],"study":[144],"was":[145,281,376],"evaluate":[147],"image":[151,192],"texture":[152,193,236,343],"differentiate":[155],"benign":[156,218],"clusters":[157,296],"digitized":[161],"BDB":[162],"specimens.":[163],"Textural":[164],"descriptors":[165],"able":[167,210],"characterize":[169],"local":[170],"regions":[171],"interest":[173],"within":[174],"malignant":[175,216,309],"lesions":[176],"by":[177,221,310,411],"computing":[178],"spatial":[179],"arrangements":[180],"statistics":[182],"color":[184],"intensities.":[185],"Typical":[186],"used":[189,315,364],"characterizing":[191],"include":[194],"Gabor,":[195],"Law,":[196],"Haralick,":[197],"Co-occurrence":[199],"Local":[201],"Anisotropic":[202],"Gradient":[203],"Orientations":[204],"(CoLlAGe)":[205],"features.":[206],"These":[207],"capture":[212],"subtle":[213],"differences":[214],"phenotypes":[219],"caused":[220],"multitude":[223],"phenotypic":[225],"changes,":[226],"including":[227],"nuclear":[228],"overcrowding,":[229],"disorientation,":[230],"disorderly":[232],"chromatin":[233],"distribution.":[234],"Pixel-wise":[235],"from":[238,259],"family":[240],"were":[241,258,275,290,297,306,329,345],"computed":[242],"whole":[244],"slide":[245,301],"images":[246],"(WSIs)":[247],"BDBs":[249],"corresponding":[250],"59":[252],"unique":[253],"patients":[254,260,427,434],"31":[257],"pathologically":[261],"confirmed":[262,276],"as":[263,277,308,316],"having":[264],"through":[267],"next":[268],"generation":[269],"sequencing,":[270],"remaining":[273],"28":[274],"benign.":[278],"Each":[279],"WSI":[280],"magnified":[282],"11X,":[284],"5.5X,":[285],"2.25X":[287],"before":[288],"extracted.":[291],"A":[292,372],"total":[293],"445":[295],"annotated":[298],"across":[299],"all":[300,409],"images,":[302],"275":[305],"identified":[307],"an":[311,417],"expert":[312],"cytopathologist,":[313],"ground":[318],"truth":[319],"for":[320],"our":[321],"machine":[322,369],"learning":[323,370],"models.":[324],"pixel-wise":[326],"feature":[327],"distributions":[328],"summarized":[330],"using":[331,347,422],"mean,":[332],"median,":[333],"standard":[334,385],"deviation,":[335],"skewness,":[336],"kurtosis.":[338],"top":[340],"five":[341],"statistical":[342],"selected":[346,410],"Wilcoxon":[348],"ranksum,":[349],"two-sided":[350],"t-test,":[351],"maximum":[353],"relevance":[354],"minimum":[355],"redundancy":[356],"tests":[357],"3-fold":[359,423],"patient-wise":[360],"cross":[361],"validation":[362],"train":[366],"three":[367],"different":[368],"classifiers.":[371],"linear":[373],"discriminant":[374],"classifier":[375],"trained":[377],"mean":[380,393],"Haralick":[381],"information":[382],"measure":[383],"2,":[384],"deviation":[386],"median":[388],"CoLlAGe":[390],"correlation,":[391],"2D":[395],"Gabor":[396],"response":[397],"{0,4}Hz":[399],"frequencies":[400],"orientations":[402],"f2":[403],";":[404],"58":[405],"g":[406],"radian":[407],"orientations,":[408],"mRMR":[413],"test.":[414],"We":[415],"obtained":[416],"AUC":[418],"0:83":[420],"±0:01":[421],"cross-validation":[424],"39":[426],"training":[430],"set":[431],"20":[433],"testing":[437],"set.":[438]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}