{"id":"https://openalex.org/W3011502486","doi":"https://doi.org/10.1117/12.2550651","title":"How well do U-Net-based segmentation trained on adult cardiac magnetic resonance imaging data generalize to rare congenital heart diseases for surgical planning?","display_name":"How well do U-Net-based segmentation trained on adult cardiac magnetic resonance imaging data generalize to rare congenital heart diseases for surgical planning?","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3011502486","doi":"https://doi.org/10.1117/12.2550651","mag":"3011502486"},"language":"en","primary_location":{"id":"doi:10.1117/12.2550651","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2550651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013534548","display_name":"Sven Koehler","orcid":"https://orcid.org/0000-0003-4989-8766"},"institutions":[{"id":"https://openalex.org/I112756935","display_name":"Technische Hochschule Mannheim","ror":"https://ror.org/04p61dj41","country_code":"DE","type":"education","lineage":["https://openalex.org/I112756935"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sven Koehler","raw_affiliation_strings":["Mannheim Univ. of Applied Science (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mannheim Univ. of Applied Science (Germany)","institution_ids":["https://openalex.org/I112756935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086840233","display_name":"Animesh Tandon","orcid":"https://orcid.org/0000-0001-9769-8801"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Animesh Tandon","raw_affiliation_strings":["Univ. of Texas Southwestern Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Southwestern Medical Ctr. (United States)","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633334","display_name":"Tariq Hussain","orcid":"https://orcid.org/0000-0002-1332-2418"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarique Hussain","raw_affiliation_strings":["Univ. of Texas Southwestern Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Southwestern Medical Ctr. (United States)","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017218111","display_name":"Heiner Latus","orcid":"https://orcid.org/0000-0003-3939-6025"},"institutions":[{"id":"https://openalex.org/I4210148371","display_name":"Deutsches Herzzentrum M\u00fcnchen","ror":"https://ror.org/04hbwba26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210148371","https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiner Latus","raw_affiliation_strings":["German Heart Ctr. Munich (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Heart Ctr. Munich (Germany)","institution_ids":["https://openalex.org/I4210148371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053021121","display_name":"Thomas Pickardt","orcid":"https://orcid.org/0000-0003-0019-6325"},"institutions":[{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Pickardt","raw_affiliation_strings":["German Ctr. for Cardiovascular Research (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Ctr. for Cardiovascular Research (Germany)","institution_ids":["https://openalex.org/I4210127591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033197648","display_name":"Samir Sarikouch","orcid":"https://orcid.org/0000-0001-7277-7597"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Samir Sarikouch","raw_affiliation_strings":["German Ctr. for Cardiovascular Research (Germany)","Hannover Medical School (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Ctr. for Cardiovascular Research (Germany)","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Hannover Medical School (Germany)","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066066263","display_name":"Philipp Beerbaum","orcid":"https://orcid.org/0000-0001-9090-0392"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Beerbaum","raw_affiliation_strings":["Hannover Medical School (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School (Germany)","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006592104","display_name":"Gerald Greil","orcid":"https://orcid.org/0000-0001-7288-6566"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Greil","raw_affiliation_strings":["Univ. of Texas Southwestern Medical Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Southwestern Medical Ctr. (United States)","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088137293","display_name":"Sandy Engelhardt","orcid":"https://orcid.org/0000-0001-8816-7654"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandy Engelhardt","raw_affiliation_strings":["Heidelberg Univ. Hospital (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg Univ. Hospital (Germany)","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029228546","display_name":"Ivo Wolf","orcid":"https://orcid.org/0000-0002-6519-6484"},"institutions":[{"id":"https://openalex.org/I112756935","display_name":"Technische Hochschule Mannheim","ror":"https://ror.org/04p61dj41","country_code":"DE","type":"education","lineage":["https://openalex.org/I112756935"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ivo Wolf","raw_affiliation_strings":["Mannheim Univ. of Applied Science (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mannheim Univ. of Applied Science (Germany)","institution_ids":["https://openalex.org/I112756935"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5915,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68190021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"55","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.7306764721870422},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6255560517311096},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance","display_name":"Cardiac magnetic resonance","score":0.5669630765914917},{"id":"https://openalex.org/keywords/surgical-planning","display_name":"Surgical planning","score":0.5105043649673462},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.46976327896118164},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.39914751052856445},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39083701372146606},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36486905813217163},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3236904740333557}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7306764721870422},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6255560517311096},{"id":"https://openalex.org/C2987145844","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance","level":3,"score":0.5669630765914917},{"id":"https://openalex.org/C2779370443","wikidata":"https://www.wikidata.org/wiki/Q1776627","display_name":"Surgical planning","level":2,"score":0.5105043649673462},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.46976327896118164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39914751052856445},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39083701372146606},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36486905813217163},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3236904740333557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2550651","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2550651","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5199999809265137,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3021493803","https://openalex.org/W2257755506","https://openalex.org/W2011111248","https://openalex.org/W4256129901","https://openalex.org/W2002934375","https://openalex.org/W2006468016","https://openalex.org/W2912860444","https://openalex.org/W1907269663","https://openalex.org/W1992188083","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Planning":[0],"the":[1,14,57,67,108,152,175,181,223,232,237],"optimal":[2],"time":[3],"of":[4,19,35,45,136,199],"intervention":[5],"for":[6,94,127,231,236],"pulmonary":[7],"valve":[8],"replacement":[9],"surgery":[10],"in":[11,56,71],"patients":[12,138],"with":[13,166],"congenital":[15],"heart":[16],"disease":[17],"Tetralogy":[18],"Fallot":[20],"(TOF)":[21],"is":[22,100],"mainly":[23],"based":[24],"on":[25,66,174],"ventricular":[26],"volume":[27],"and":[28,82,129,139,142,234],"function":[29],"according":[30],"to":[31,133,154,212,222],"current":[32,188],"guidelines.":[33],"Both":[34],"these":[36],"two":[37],"biomarkers":[38],"are":[39,76,210],"most":[40],"reliably":[41],"assessed":[42,107],"by":[43],"segmentation":[44],"3D":[46],"cardiac":[47],"magnetic":[48],"resonance":[49],"(CMR)":[50],"images.":[51],"In":[52],"several":[53],"grand":[54],"challenges":[55],"last":[58],"years,":[59],"U-Net":[60],"architectures":[61],"have":[62],"shown":[63],"impressive":[64],"results":[65,149,185,195],"provided":[68],"data.":[69],"However,":[70],"clinical":[72],"practice,":[73],"data":[74,93,117,125,135,158,205],"sets":[75],"more":[77,156],"diverse":[78],"considering":[79],"individual":[80],"pathologies":[81,225],"image":[83],"properties":[84],"derived":[85],"from":[86,180],"different":[87],"scanner":[88],"properties.":[89],"Additionally,":[90],"specific":[91],"training":[92,128,224],"complex":[95],"rare":[96],"diseases":[97],"like":[98],"TOF":[99,137],"scarce.":[101],"For":[102],"this":[103],"work,":[104],"1)":[105],"we":[106,145],"accuracy":[109],"gap":[110],"when":[111,150],"using":[112],"a":[113,155,203],"publicly":[114],"available":[115],"labelled":[116],"set":[118],"(the":[119],"Automatic":[120],"Cardiac":[121],"Diagnosis":[122],"Challenge":[123],"(ACDC)":[124],"set)":[126],"subsequent":[130],"applying":[131,151],"it":[132,215],"CMR":[134,178],"vice":[140],"versa":[141],"2)":[143],"whether":[144],"can":[146,192],"achieve":[147,193],"similar":[148],"model":[153],"heterogeneous":[157],"base.":[159],"Multiple":[160],"deep":[161,189],"learning":[162,190],"models":[163,191],"were":[164,172],"trained":[165],"four-fold":[167],"cross":[168],"validation.":[169],"Afterwards":[170],"they":[171,209,220],"evaluated":[173],"respective":[176],"unseen":[177],"images":[179],"other":[182,213],"collection.":[183,206],"Our":[184],"confirm":[186],"that":[187],"excellent":[194],"(left":[196],"ventricle":[197],"dice":[198],"0.951±0.003/0.941±0.0007":[200],"train/validation)":[201],"within":[202],"single":[204],"But":[207],"once":[208],"applied":[211],"pathologies,":[214],"becomes":[216],"apparent":[217],"how":[218],"much":[219],"overfit":[221],"(dice":[226],"score":[227],"drops":[228],"between":[229],"0.072±0.001":[230],"left":[233],"0.165±0.001":[235],"right":[238],"ventricle).":[239]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}