{"id":"https://openalex.org/W3011050042","doi":"https://doi.org/10.1117/12.2549729","title":"Mutual information for unsupervised deep learning image registration","display_name":"Mutual information for unsupervised deep learning image registration","publication_year":2020,"publication_date":"2020-03-10","ids":{"openalex":"https://openalex.org/W3011050042","doi":"https://doi.org/10.1117/12.2549729","mag":"3011050042"},"language":"en","primary_location":{"id":"doi:10.1117/12.2549729","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549729","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Image Processing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/files/137969972/Mutual-information-for-unsupervised-deep-learning-image-registration.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018266214","display_name":"Bob D. de Vos","orcid":"https://orcid.org/0000-0002-8358-6849"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Bob D. de Vos","raw_affiliation_strings":["Amsterdam Univ. Medical Ctr. (Netherlands)","Univ. Medical Ctr. Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Amsterdam Univ. Medical Ctr. (Netherlands)","institution_ids":[]},{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087707300","display_name":"Bas van der Velden","orcid":null},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bas van der Velden","raw_affiliation_strings":["Univ. Medical Ctr. Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103072259","display_name":"J\u00f6rg Sander","orcid":"https://orcid.org/0000-0001-5047-9257"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Sander","raw_affiliation_strings":["Amsterdam Univ. Medical Ctr. (Netherlands)","Univ. Medical Ctr. Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Amsterdam Univ. Medical Ctr. (Netherlands)","institution_ids":[]},{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033195086","display_name":"Kenneth G. A. Gilhuijs","orcid":"https://orcid.org/0000-0003-2087-8649"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kenneth Gilhuijs","raw_affiliation_strings":["Image Sciences Institute, Univ. Medical Ctr. Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025788902","display_name":"Marius Staring","orcid":"https://orcid.org/0000-0003-2885-5812"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marius Staring","raw_affiliation_strings":["Leiden Univ. Medical Ctr. (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Leiden Univ. Medical Ctr. (Netherlands)","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084070018","display_name":"Ivana I\u0161gum","orcid":"https://orcid.org/0000-0003-1869-5034"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ivana I\u0161gum","raw_affiliation_strings":["Amsterdam Univ. Medical Ctr. (Netherlands)","Amsterdan Univ. Medical Ctr. (Netherlands)","Image Sciences Institute, Univ. Medical Ctr. Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Amsterdam Univ. Medical Ctr. (Netherlands)","institution_ids":[]},{"raw_affiliation_string":"Amsterdan Univ. Medical Ctr. (Netherlands)","institution_ids":[]},{"raw_affiliation_string":"Image Sciences Institute, Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018266214"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":null,"apc_paid":null,"fwci":1.8647,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.87766301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.9085417985916138},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.792935848236084},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7781395316123962},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.6879592537879944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6762422919273376},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5900633335113525},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.5596982836723328},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5322774648666382},{"id":"https://openalex.org/keywords/relation","display_name":"Relation (database)","score":0.5198405385017395},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.4948107600212097},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4648738205432892},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.44441384077072144},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43897613883018494},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2464950978755951},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.16816529631614685}],"concepts":[{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.9085417985916138},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.792935848236084},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7781395316123962},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.6879592537879944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6762422919273376},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5900633335113525},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5596982836723328},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5322774648666382},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.5198405385017395},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.4948107600212097},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4648738205432892},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.44441384077072144},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43897613883018494},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2464950978755951},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.16816529631614685},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1117/12.2549729","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549729","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Image Processing","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/b314deeb-1148-47fd-b9d1-78cd881dfd8e","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/b314deeb-1148-47fd-b9d1-78cd881dfd8e","pdf_url":"https://pure.amsterdamumc.nl/files/137969972/Mutual-information-for-unsupervised-deep-learning-image-registration.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Vos, B D, van der Velden, B H M, Sander, J, Gilhuijs, K G A, Staring, M & I\u0161gum, I 2020, Mutual information for unsupervised deep learning image registration. in Medical Imaging 2020 : Image Processing. vol. 11313, 2549729, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11313, SPIE, Medical Imaging 2020: Image Processing, Houston, United States, 17/02/2020. https://doi.org/10.1117/12.2549729","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/96d1ebc6-02c7-434b-aa7f-1bbd9ac8f961","is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/mutual-information-for-unsupervised-deep-learning-image-registration(96d1ebc6-02c7-434b-aa7f-1bbd9ac8f961).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Imaging 2020: Image Processing, 11313","raw_type":"info:eu-repo/semantics/conferencepaper"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/608715","is_oa":false,"landing_page_url":"https://research.wur.nl/en/publications/mutual-information-for-unsupervised-deep-learning-image-registrat","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Imaging 2020. SPIE","raw_type":"info:eu-repo/semantics/conferencepaper"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/b314deeb-1148-47fd-b9d1-78cd881dfd8e","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/b314deeb-1148-47fd-b9d1-78cd881dfd8e","pdf_url":"https://pure.amsterdamumc.nl/files/137969972/Mutual-information-for-unsupervised-deep-learning-image-registration.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Vos, B D, van der Velden, B H M, Sander, J, Gilhuijs, K G A, Staring, M & I\u0161gum, I 2020, Mutual information for unsupervised deep learning image registration. in Medical Imaging 2020 : Image Processing. vol. 11313, 2549729, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11313, SPIE, Medical Imaging 2020: Image Processing, Houston, United States, 17/02/2020. https://doi.org/10.1117/12.2549729","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G4417598090","display_name":null,"funder_award_id":"P15-26","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G629491556","display_name":null,"funder_award_id":"(NWO)","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3011050042.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2426195296","https://openalex.org/W1970834875","https://openalex.org/W2367847708","https://openalex.org/W2135643201","https://openalex.org/W2370810807","https://openalex.org/W2368895820","https://openalex.org/W2156531368","https://openalex.org/W2548524143","https://openalex.org/W1837349379","https://openalex.org/W2387425358"],"abstract_inverted_index":{"Current":[0],"unsupervised":[1,70],"deep":[2,71],"learning-based":[3],"image":[4,34,46,73,107],"registration":[5,26,47,74,108],"methods":[6],"are":[7,23],"trained":[8],"with":[9,94,105,129],"mean":[10],"squares":[11],"or":[12],"nor-":[13],"malized":[14],"cross":[15,131],"correlation":[16,132],"as":[17,66,97],"a":[18,30,39,67,98],"similarity":[19],"metric.":[20],"These":[21],"metrics":[22],"suitable":[24],"for":[25,69],"of":[27,52],"images":[28],"where":[29],"linear":[31],"relation":[32,40],"between":[33],"intensities":[35],"exists.":[36],"When":[37],"such":[38],"is":[41,119],"absent":[42],"knowledge":[43],"from":[44],"conventional":[45,106],"literature":[48],"suggests":[49],"the":[50,114],"use":[51],"mutual":[53,61,95],"information.":[54],"In":[55],"this":[56],"work":[57],"we":[58],"investigate":[59],"whether":[60],"information":[62,96],"can":[63],"be":[64],"used":[65],"loss":[68,99],"learning":[72],"by":[75],"evaluating":[76],"it":[77,118,123],"on":[78,101,125],"two":[79],"datasets:":[80],"breast":[81],"dynamic":[82],"contrast-enhanced":[83],"MR":[84,87],"and":[85,113],"cardiac":[86],"images.":[88],"The":[89],"results":[90,115],"show":[91,116],"that":[92,117],"training":[93],"gives":[100],"par":[102,126],"performance":[103,127],"compared":[104,128],"in":[109,133],"contrast":[110],"enhanced":[111],"images,":[112],"generally":[120],"applicable":[121],"since":[122],"has":[124],"normalized":[130],"single-modality":[134],"registration.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}