{"id":"https://openalex.org/W3012099753","doi":"https://doi.org/10.1117/12.2549680","title":"A data-driven approach for stratifying psychotic and mood disorders subjects using structural magnitude resonance imaging data","display_name":"A data-driven approach for stratifying psychotic and mood disorders subjects using structural magnitude resonance imaging data","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3012099753","doi":"https://doi.org/10.1117/12.2549680","mag":"3012099753"},"language":"en","primary_location":{"id":"doi:10.1117/12.2549680","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549680","pdf_url":null,"source":{"id":"https://openalex.org/S4306519512","display_name":"Medical Imaging 2020: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Computer-Aided Diagnosis","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080168099","display_name":"Hooman Rokham","orcid":"https://orcid.org/0000-0002-2650-0156"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hooman Rokham","raw_affiliation_strings":["Emory Univ. (United States)","Georgia Institute of Technology (United States)","Georgia State Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia State Univ. (United States)","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002724897","display_name":"Haleh Falakshahi","orcid":"https://orcid.org/0000-0003-2202-1016"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haleh Falakshahi","raw_affiliation_strings":["Emory Univ. (United States)","Georgia Institute of Technology (United States)","Georgia State Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia State Univ. (United States)","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032850756","display_name":"Vince D. Calhoun","orcid":"https://orcid.org/0000-0001-9058-0747"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vince D. Calhoun","raw_affiliation_strings":["Emory Univ. (United States)","Georgia Institute of Technology (United States)","Georgia State Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia State Univ. (United States)","institution_ids":["https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080168099"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I181565077"],"apc_list":null,"apc_paid":null,"fwci":0.831,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80628198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"100","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9605000019073486,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7017555832862854},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5626064538955688},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.5413721203804016},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4953059256076813},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.48554298281669617},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.42115259170532227},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4089812636375427},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2071026861667633}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7017555832862854},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5626064538955688},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5413721203804016},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4953059256076813},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.48554298281669617},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.42115259170532227},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4089812636375427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2071026861667633},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2549680","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549680","pdf_url":null,"source":{"id":"https://openalex.org/S4306519512","display_name":"Medical Imaging 2020: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Computer-Aided Diagnosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804364458","https://openalex.org/W4298130764","https://openalex.org/W2132641928","https://openalex.org/W4310225030","https://openalex.org/W2090259340","https://openalex.org/W3021493803","https://openalex.org/W2257755506","https://openalex.org/W2083665254","https://openalex.org/W2393816671","https://openalex.org/W2158836806"],"abstract_inverted_index":{"Psychotic":[0],"disorders":[1,78],"such":[2],"as":[3],"schizophrenia":[4],"and":[5,60,93,116,132,144,168,205,213,228,232],"bipolar":[6],"disorder":[7],"are":[8,25],"difficult":[9],"to":[10,31,225],"classify":[11],"because":[12,27],"they":[13,28],"share":[14],"overlapping":[15],"symptoms.":[16],"Deriving":[17],"biomarkers":[18],"of":[19,56,72,76,150,181,208],"illness":[20,199],"using":[21,41,79,87,114,141,187,218],"structural":[22,106],"MRI":[23,107],"dataset":[24],"essential":[26],"may":[29,52,61,200,222],"lead":[30,224],"improved":[32,185,226],"diagnosis.":[33],"Previous":[34],"studies":[35],"typically":[36],"predict":[37],"the":[38,54,57,70,90,98,179,182,209],"diagnosis":[39,74,227],"labels":[40],"supervised":[42],"classifiers":[43],"that":[44],"rely":[45],"on":[46,89,97,104,128],"truly":[47],"labeled":[48,113],"dataset.":[49],"Mislabeled":[50],"subjects":[51,112],"increase":[53],"complexity":[55],"predictive":[58,183],"model":[59,184],"impact":[62],"its":[63],"performance.":[64],"In":[65],"this":[66],"work,":[67],"we":[68,153],"address":[69],"problem":[71],"inaccurate":[73],"labeling":[75],"psychotic":[77],"a":[80,105,219],"data-driven":[81,220],"approach.":[82],"We":[83,100],"performed":[84,124],"dimension":[85],"reduction":[86],"PCA":[88],"vectorized":[91],"images":[92],"then":[94],"k-mean":[95],"clustering":[96,126],"components.":[99],"evaluate":[101],"our":[102,142],"method":[103,191],"dataset,":[108],"with":[109,197],"over":[110],"900":[111],"DSM-IV":[115],"biotypes.":[117],"An":[118],"ANOVA":[119],"statistical":[120],"significance":[121],"test":[122],"was":[123],"after":[125,133],"based":[127],"each":[129,145],"labelling":[130],"approach":[131,221],"clustering.":[134],"Subjects":[135],"were":[136,171],"grouped":[137],"into":[138],"5":[139,163],"clusters":[140],"method,":[143],"cluster":[146],"includes":[147],"all":[148],"types":[149],"patients.":[151,234],"However,":[152],"found":[154],"statistically":[155],"significant":[156,173],"group":[157],"differences":[158],"in":[159],"brain":[160,210,215],"regions":[161],"across":[162],"clusters,":[164],"while":[165],"for":[166],"DSM":[167],"biotype,":[169],"there":[170],"no":[172],"differences.":[174],"Our":[175,190],"results":[176],"also":[177],"show":[178],"performance":[180],"significantly":[186],"datadriven":[188],"labels.":[189],"shows":[192],"underlying":[193],"biological":[194],"changes":[195],"associated":[196],"mental":[198],"be":[201],"identified":[202],"by":[203],"studying":[204],"considering":[206],"features":[207],"imaging":[211,216],"data,":[212],"annotating":[214],"data":[217],"eventually":[223],"advanced":[229],"drug":[230],"discovery":[231],"help":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
