{"id":"https://openalex.org/W3012124463","doi":"https://doi.org/10.1117/12.2549650","title":"Predicting MYC translocation in HE specimens of diffuse large B-cell lymphoma through deep learning","display_name":"Predicting MYC translocation in HE specimens of diffuse large B-cell lymphoma through deep learning","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3012124463","doi":"https://doi.org/10.1117/12.2549650","mag":"3012124463"},"language":"en","primary_location":{"id":"doi:10.1117/12.2549650","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549650","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Digital Pathology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076314803","display_name":"\u017baneta \u015awiderska-Chadaj","orcid":"https://orcid.org/0000-0003-2115-9822"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zaneta Swiderska-Chadaj","raw_affiliation_strings":["Radboud Univ. Medical Ctr. (Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud Univ. Medical Ctr. (Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025898022","display_name":"Konnie M. Hebeda","orcid":"https://orcid.org/0000-0002-4181-3302"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Konnie Hebeda","raw_affiliation_strings":["Radboud Univ. Medical Ctr. (Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud Univ. Medical Ctr. (Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025624708","display_name":"Michiel van den Brand","orcid":"https://orcid.org/0000-0001-8871-6254"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michiel van den Brand","raw_affiliation_strings":["Radboud Univ. Medical Ctr. (Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud Univ. Medical Ctr. (Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055697525","display_name":"Geert Litjens","orcid":"https://orcid.org/0000-0003-1554-1291"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert Litjens","raw_affiliation_strings":["Radboud Univ. Medical Ctr. (Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radboud Univ. Medical Ctr. (Netherlands)","institution_ids":["https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4286,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60638113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"Chromosomal translocation","score":0.9240058660507202},{"id":"https://openalex.org/keywords/lymphoma","display_name":"Lymphoma","score":0.7490029335021973},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"Fluorescence in situ hybridization","score":0.7419090867042542},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"Diffuse large B-cell lymphoma","score":0.6982997059822083},{"id":"https://openalex.org/keywords/fish-actinopterygii","display_name":"Fish <Actinopterygii>","score":0.5178918838500977},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.37902143597602844},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3743612766265869},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.356140673160553},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3364560604095459},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3330042064189911},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3221889138221741},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2995690703392029},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12903934717178345},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.06508424878120422}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.9240058660507202},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7490029335021973},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.7419090867042542},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.6982997059822083},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.5178918838500977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37902143597602844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3743612766265869},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.356140673160553},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3364560604095459},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3330042064189911},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3221889138221741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2995690703392029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12903934717178345},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.06508424878120422},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2549650","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549650","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Digital Pathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059214052","https://openalex.org/W1975964136","https://openalex.org/W2367208703","https://openalex.org/W2367253219","https://openalex.org/W2377233807","https://openalex.org/W1987823376","https://openalex.org/W2401792989","https://openalex.org/W4250397071","https://openalex.org/W4252143589","https://openalex.org/W2976698168"],"abstract_inverted_index":{"Diffuse":[0],"large":[1,230],"B-cell":[2,11],"lymphoma":[3],"(DLBCL)":[4],"is":[5,14,36,48,56,62],"the":[6,45,75,92,99,120,134,156,196],"most":[7],"common":[8],"type":[9],"of":[10,29,77,94,105,119,146,179,183,190,198,204,221,232],"lymphoma.":[12],"It":[13],"characterized":[15],"by":[16],"a":[17,32,51,95,112,142,191,205,229],"heterogeneous":[18],"morphology,":[19],"genetic":[20,64,206],"changes":[21,73,207],"and":[22,42,58,137,155,176,181],"clinical":[23],"behavior.":[24],"A":[25],"small":[26],"specific":[27],"subgroup":[28],"DLBCL,":[30],"harbouring":[31],"MYC":[33,46,96,121,157],"gene":[34],"translocation":[35,47,97,158],"associated":[37],"with":[38,50,153],"worse":[39],"patient":[40],"prognosis":[41],"outcome.":[43],"Typically,":[44],"assessed":[49],"molecular":[52],"test":[53],"(FISH),":[54],"that":[55,63],"expensive":[57],"time-consuming.":[59],"Our":[60],"hypothesis":[61],"changes,":[65],"such":[66],"as":[67,72],"translocations":[68,122],"could":[69],"be":[70],"visible":[71],"in":[74,98,123,163,195,208,228],"morphology":[76],"an":[78,172],"HE-stained":[79,127],"specimen.":[80],"However,":[81],"it":[82],"has":[83],"not":[84],"proven":[85],"possible":[86],"to":[87,103,116,224],"use":[88],"morphological":[89],"criteria":[90],"for":[91,202,218],"detection":[93,118,203],"diagnostic":[100],"setting":[101],"due":[102],"lack":[104],"specificity.":[106],"In":[107,210],"this":[108],"paper,":[109],"we":[110,213],"apply":[111],"deep":[113,199],"learning":[114,200],"model":[115],"automate":[117],"DLBCL":[124,222],"based":[125,140],"on":[126,141,171],"specimens.":[128],"The":[129,167,185],"proposed":[130,186],"method":[131,187],"works":[132],"at":[133],"whole-slide":[135],"level":[136],"was":[138,159,169],"developed":[139],"multicenter":[143],"data":[144],"cohort":[145],"91":[147],"patients.":[148,233],"All":[149],"specimens":[150,223],"were":[151],"stained":[152],"HE,":[154],"confirmed":[160],"using":[161],"fluorescence":[162],"situ":[164],"hybridization":[165],"(FISH).":[166],"system":[168],"evaluated":[170],"additional":[173],"66":[174],"patients,":[175],"obtained":[177],"AUROC":[178],"0.83":[180],"accuracy":[182],"0.77.":[184],"presents":[188],"proof":[189],"concept":[192],"giving":[193],"insights":[194],"applicability":[197],"methods":[201],"DLBCL.":[209],"future":[211],"work":[212],"will":[214],"evaluate":[215],"our":[216],"algorithm":[217],"automatic":[219],"pre-screen":[220],"obviate":[225],"FISH":[226],"analysis":[227],"number":[231]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}