{"id":"https://openalex.org/W3006720299","doi":"https://doi.org/10.1117/12.2549628","title":"MRI-based radiomics of sarcomas in the preclinical arm of a co-clinical trial","display_name":"MRI-based radiomics of sarcomas in the preclinical arm of a co-clinical trial","publication_year":2020,"publication_date":"2020-02-28","ids":{"openalex":"https://openalex.org/W3006720299","doi":"https://doi.org/10.1117/12.2549628","mag":"3006720299"},"language":"en","primary_location":{"id":"doi:10.1117/12.2549628","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549628","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046928479","display_name":"Matt Holbrook","orcid":"https://orcid.org/0000-0002-5832-8725"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew D. Holbrook","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067317237","display_name":"Stephanie J. Blocker","orcid":"https://orcid.org/0000-0002-6665-7844"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J. Blocker","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061908198","display_name":"Yvonne M. Mowery","orcid":"https://orcid.org/0000-0002-9839-2414"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne Mowery","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051190025","display_name":"Alexandra Badea","orcid":"https://orcid.org/0000-0001-6621-4560"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Badea","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074663646","display_name":"Yi Qi","orcid":"https://orcid.org/0000-0002-5365-5583"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Qi","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070216920","display_name":"David G. Kirsch","orcid":"https://orcid.org/0000-0002-2086-205X"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Kirsch","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012481366","display_name":"Cristian T. Badea","orcid":"https://orcid.org/0000-0002-1850-2522"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristian T. Badea","raw_affiliation_strings":["Duke Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5046928479"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0172367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.9148530960083008},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7260088324546814},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.574723482131958},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4739542007446289},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4314480423927307},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.42076390981674194},{"id":"https://openalex.org/keywords/sarcoma","display_name":"Sarcoma","score":0.41712191700935364},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4121442437171936},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41151198744773865},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2623899579048157}],"concepts":[{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.9148530960083008},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7260088324546814},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.574723482131958},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4739542007446289},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4314480423927307},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42076390981674194},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.41712191700935364},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4121442437171936},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41151198744773865},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2623899579048157},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2549628","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549628","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3000891326","https://openalex.org/W4205100762","https://openalex.org/W2734724112","https://openalex.org/W2582997534","https://openalex.org/W3009210156","https://openalex.org/W4388577230","https://openalex.org/W4385221818","https://openalex.org/W3030796519","https://openalex.org/W4383892348","https://openalex.org/W4390866092"],"abstract_inverted_index":{"Radiomics":[0],"provide":[1],"an":[2],"exciting":[3],"approach":[4],"to":[5,95,98,142,151,211,243],"developing":[6],"imaging":[7],"biomarkers":[8],"in":[9,223,230,245],"the":[10,18,48,78,82,89,118,123,143,219,224,251],"context":[11],"of":[12,21,27,43,50,145,214,250],"precision":[13],"medicine.":[14],"We":[15,114],"focus":[16],"on":[17,135,172],"preclinical":[19,248],"arm":[20,249],"a":[22,38,240],"co-clinical":[23,252],"trial":[24],"investigating":[25],"synergy":[26],"immunotherapy":[28],"combined":[29,124,225],"with":[30,53,58,218],"radiation":[31],"therapy":[32],"(RT)":[33],"and":[34,56,73,88,122,126,175,195,227],"surgical":[35],"resection":[36],"using":[37,111],"genetically":[39],"engineered":[40],"mouse":[41],"model":[42],"sarcoma.":[44],"Our":[45,129,147,179],"protocol":[46],"involves":[47],"acquisition":[49,81],"MRI":[51,64,80],"data":[52,232],"T1,":[54],"T2":[55],"T1":[57],"contrast":[59],"agent.":[60],"There":[61],"are":[62,91,109,139],"two":[63],"time":[65],"points":[66],"i.e.":[67],"one":[68,74],"day":[69],"before":[70],"RT":[71],"(20Gy)":[72],"week":[75],"later.":[76],"After":[77],"second":[79,148],"primary":[83,158,215],"tumor":[84,107,125,159,197,216,226],"is":[85],"surgically":[86],"removed,":[87],"mice":[90],"followed":[92],"for":[93,100,117,168],"up":[94],"6":[96],"months":[97],"investigate":[99],"local":[101],"recurrence":[102,160,217],"or":[103],"distant":[104],"metastases.":[105],"The":[106,203],"images":[108],"segmented":[110],"deep":[112],"learning.":[113],"performed":[115],"radiomics":[116,131,154,208,241],"tumor,":[119],"peritumoral":[120,127,228],"rim":[121],"rim.":[128],"first":[130],"analysis":[132,149],"was":[133],"focused":[134],"determining":[136],"features":[137,155,165,186,209],"which":[138],"most":[140],"indicative":[141],"effects":[144],"RT.":[146,202],"aimed":[150],"answer":[152],"if":[153],"could":[156],"predict":[157],"within":[161],"this":[162],"population.":[163],"Top":[164],"were":[166],"selected":[167],"training":[169],"classifiers":[170],"based":[171],"neural":[173],"networks":[174],"support":[176],"vector":[177],"machines.":[178],"results":[180,204],"show":[181,187],"that":[182,188,196,207],"gray":[183],"level":[184],"radiomic":[185],"tumors":[189],"often":[190],"acquire":[191],"more":[192],"heterogeneous":[193],"texture":[194],"volume":[198],"increases":[199],"one-week":[200],"post":[201],"also":[205],"suggest":[206],"serve":[210,244],"indicate":[212],"likelihood":[213],"best":[220],"predictive":[221],"power":[222],"area":[229],"pre-RT":[231],"(AUC:":[233],"0.83).":[234],"In":[235],"conclusion,":[236],"we":[237],"have":[238],"created":[239],"pipeline":[242],"our":[246],"current":[247],"trial.":[253]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}