{"id":"https://openalex.org/W3006187728","doi":"https://doi.org/10.1117/12.2549010","title":"Multilevel survival analysis with structured penalties for imaging genetics data","display_name":"Multilevel survival analysis with structured penalties for imaging genetics data","publication_year":2020,"publication_date":"2020-03-10","ids":{"openalex":"https://openalex.org/W3006187728","doi":"https://doi.org/10.1117/12.2549010","mag":"3006187728"},"language":"en","primary_location":{"id":"doi:10.1117/12.2549010","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Image Processing","raw_type":"proceedings-article"},"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://inria.hal.science/hal-02473825","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043406904","display_name":"Pascal Lu","orcid":"https://orcid.org/0000-0002-0493-0411"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascal Lu","raw_affiliation_strings":["INRIA Paris (France)","Sorbonne Univ. Inserm, CNRS, Institut du Cerveau et la Moelle, Ap-HP (France)"],"affiliations":[{"raw_affiliation_string":"INRIA Paris (France)","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"Sorbonne Univ. Inserm, CNRS, Institut du Cerveau et la Moelle, Ap-HP (France)","institution_ids":["https://openalex.org/I4210152724","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005778444","display_name":"Olivier Colliot","orcid":"https://orcid.org/0000-0002-9836-654X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Colliot","raw_affiliation_strings":["INRIA Paris (France)","Sorbonne Univ. Inserm, CNRS, Institut du Cerveau et la Moelle, AP-HP (France)"],"affiliations":[{"raw_affiliation_string":"INRIA Paris (France)","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"Sorbonne Univ. Inserm, CNRS, Institut du Cerveau et la Moelle, AP-HP (France)","institution_ids":["https://openalex.org/I4210152724","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I1294671590","https://openalex.org/I4210097159"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043406904"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"],"apc_list":null,"apc_paid":null,"fwci":0.4179,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59068396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9081000089645386,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9081000089645386,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5564252138137817},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4405428469181061},{"id":"https://openalex.org/keywords/imaging-genetics","display_name":"Imaging genetics","score":0.42416226863861084},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24703839421272278},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.12499439716339111},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.10170921683311462}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5564252138137817},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4405428469181061},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.42416226863861084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24703839421272278},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12499439716339111},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.10170921683311462}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2549010","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2549010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2020: Image Processing","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:hal-02473825v1","is_oa":true,"landing_page_url":"https://inria.hal.science/hal-02473825","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SPIE Medical Imaging Conference, Feb 2020, Houston, United States","raw_type":"Conference papers"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-02473825v1","is_oa":true,"landing_page_url":"https://inria.hal.science/hal-02473825","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SPIE Medical Imaging Conference, Feb 2020, Houston, United States","raw_type":"Conference papers"},"sustainable_development_goals":[{"score":0.7200000286102295,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"Predicting":[0],"the":[1,43,67,95,104,114,125,142,149,168,178,189,192,220],"future":[2,152],"occurrence":[3],"of":[4,18,36,103,116,128,199],"Alzheimer\u2019s":[5],"disease":[6],"(AD)":[7],"in":[8,132,145,188],"patients":[9,44],"with":[10],"mild":[11],"cognitive":[12],"impairment":[13],"(MCI)":[14],"is":[15,64,77,206],"a":[16,28,33,59,71,84,160,226],"topic":[17],"active":[19],"research.":[20],"Many":[21],"papers":[22,131],"have":[23,46,56],"formulated":[24],"this":[25,156],"question":[26,63],"as":[27],"classification":[29,133],"problem:":[30],"one":[31],"considers":[32],"fixed":[34],"time":[35,52],"conversion":[37,169],"and":[38,53,89,138,180,201,213,223],"aims":[39],"to":[40,48,65,73,113,118,147,166,171,225],"discriminate":[41],"between":[42,177],"who":[45,55],"converted":[47],"AD":[49],"at":[50,69],"that":[51],"those":[54],"not.":[57],"However,":[58],"clinically":[60],"more":[61],"relevant":[62],"predict":[66,148],"date":[68,170],"which":[70],"patient":[72],"AD.":[74,119],"Survival":[75],"analysis":[76],"an":[78,101,185],"adequate":[79],"statistical":[80],"framework":[81],"for":[82,94],"such":[83],"task.":[85],"Multimodal":[86],"data":[87,99,165,218],"(imaging":[88],"genetic)":[90],"provide":[91,124],"complementary":[92],"information":[93],"prediction.":[96],"While":[97],"imaging":[98,137,179,214],"provides":[100],"estimate":[102,167],"current":[105,150],"patient\u2019s":[106,153],"state,":[107],"genetic":[108,139,181,209],"variants":[109],"can":[110],"be":[111],"associated":[112],"speed":[115],"progression":[117],"Although":[120],"they":[121],"do":[122],"not":[123],"same":[126,143],"type":[127],"information,":[129],"most":[130],"or":[134,151],"regression":[135],"put":[136],"variables":[140],"on":[141,208],"level":[144],"order":[146],"state.":[154],"In":[155],"work,":[157],"we":[158],"propose":[159],"survival":[161,190],"model":[162,205],"using":[163],"multimodal":[164],"AD,":[172],"by":[173],"considering":[174],"joint":[175,197],"effects":[176],"modalities.":[182],"We":[183],"introduce":[184],"adapted":[186],"penalty":[187],"model,":[191],"group":[193],"lasso":[194],"penalty,":[195],"over":[196],"groups":[198],"genes":[200],"brain":[202],"regions.":[203],"The":[204],"evaluated":[207],"(single":[210],"nucleotide":[211],"polymorphisms)":[212],"(anatomical":[215],"MRI":[216],"measures)":[217],"from":[219],"ADNI":[221],"database,":[222],"compared":[224],"standard":[227],"Cox":[228],"model.":[229]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}